A model for determination of economic thresholds, or minimum weed population densities justifying the use of postemergence herbicide treatment, for five weed species in soybeans [Glycine max (L.) Merr.] is presented. Sensitivity analysis was performed on the model with respect to economic, statistical, and agronomic variables. The model was refined to include uncertainty about lost field days during the spraying period. Predictions from both the simple and refined models were consistent with economic theory. It was also determined that the economic threshold is sensitive to choice of data-collection ranges and functional form in weed-interference studies.