Palmer amaranth has developed resistance to at least seven herbicide sites of action in the Cotton Belt of the United States, leaving producers with fewer options to manage this weed. Previous research with corn and newly commercially released soybean systems have found the use of 4-hydroxyphenylpyruvate dioxygenase (HPPD)-inhibiting herbicides such as isoxaflutole (IFT) to be effective at managing Palmer amaranth. Consequently, a new transgenic cultivar of cotton is being developed with tolerance to IFT, allowing for in-crop applications of the herbicide. Two separate studies were conducted near Marianna, AR, in 2019 and replicated in 2020, to investigate the crop safety and utility of IFT when added to cotton herbicide programs. Herbicide programs featured IFT as a preemergence or early-postemergence option, residual herbicides in subsequent postemergence applications, and the presence or absence of a layby application. The use of IFT did not significantly impact cotton injury or yield, whereas the use of layered residual herbicides, including IFT, increased Palmer amaranth control compared to those without. Regardless of earlier use of IFT, layby applications were needed for season-long control of Palmer amaranth, entireleaf morningglory, broadleaf signalgrass, and johnsongrass, as evidenced by greater than a 20 percentage point improvement in control of all weeds when a layby application was made. Overall, findings from these studies indicate IFT to be a suitable tool for managing Palmer amaranth and will provide an additional site of action for cotton herbicide programs. Sequential herbicide applications and overlaying residuals were found to be paramount for managing Palmer amaranth throughout the season.

Experiments were conducted to compare control of entireleaf morningglory with POST applications of DPX-PE350 applied with no adjuvant, a nonionic surfactant, or crop oil concentrate in spray volumes of 94, 235, and 375 L ha−1. Control was greater with a nonionic surfactant or crop oil concentrate than with no adjuvant and control with crop oil concentrate exceeded control with the nonionic surfactant. Spray volume had no effect on efficacy. DPX-PE350 was more effective when applied to foliage only or to soil plus foliage than when applied to soil only after emergence of entireleaf morningglory. Control from soil-only applications was lower on a silty clay soil than on a silt loam soil. Except for sicklepod, mixing DPX-PE350 with fluometuron or MSMA had little effect on weed control.

The influence of temperature and relative humidity on the activity of acifluorfen, fomesafen, lactofen, and acifluorfen plus bentazon on prickly sida, pitted and entireleaf morningglory, and common cocklebur was evaluated in a growth chamber. Reduced control of all species was observed at 50% relative humidity as compared to 85% relative humidity when temperatures were higher (32/55 C day/night). Similar response to relative humidity was observed at the lower temperature (25/15 C) when treatments were applied 14 days after emergence (DAE). Changes in temperature at the same relative humidity did not alter herbicidal activity. Delaying application timing from 7 to 14 DAE decreased control by all herbicides except lactofen applied at high relative humidity, which controlled prickly sida at both 7 and 14 DAE.

Experiments were conducted in 1991 and 1992 to evaluate annual grass and broadleaf weed control with bromoxynil applied alone and with graminicides. Bromoxynil controlled velvetleaf better than entireleaf morningglory and controlled both species better than sicklepod. Mixing bromoxynil with fluazifop-P, quizalofop-P, and sethoxydim reduced control of barnyardgrass, green foxtail, large crabgrass, and shattercane. Control of broadleaf signalgrass with quizalofop-P was reduced by bromoxynil. Annual grass control with clethodim was not affected by bromoxynil.

Herbicide systems consisting of PRE, early POST, and late POST options arranged factorially were compared for control of sicklepod in narrow-row soybean with modified acetolactate synthase (ALS) (E.C.4.1.3.18). Other weeds present included common cocklebur and mixed infestations of entireleaf, ivyleaf, pitted, and tall morningglories. PRE options were alachlor or alachlor plus metribuzin plus chlorimuron. Early POST options included chlorimuron, chlorimuron plus thifensulfuron, and no herbicide applied 3 wk after planting. Late POST options were chlorimuron and no herbicide applied 5 wk after planting. POST herbicides were more effective than PRE herbicides on all weeds. Chlorimuron and chlorimuron plus thifensulfuron applied early POST were equally effective on these weeds and usually more effective than chlorimuron applied late POST. There was no advantage of two POST applications compared with a single early POST application. Greatest net returns were obtained in systems using only early POST herbicides. There was no economic advantage from using metribuzin plus chlorimuron PRE in systems that included an early POST herbicide.

Greenhouse experiments were established to investigate the effects of tank-mixing glyphosate, paraquat, or glufosinate with metribuzin plus chlorimuron, imazaquin, or metribuzin on entireleaf morningglory, sicklepod, and johnsongrass control. Antagonism was the most frequent interaction, and usually occurred when the lower rates of non-selective foliar-active herbicides were used in tank mixtures with selective soil-active herbicides. Antagonism occurred on all species when 180 g ai/ha paraquat was tank-mixed with 90 g ai/ha metribuzin plus 15 g ai/ha chlorimuron. When the rates of non-selective herbicide were increased, antagonism was usually overcome. Antagonism also occurred on entireleaf morningglory control when 210 g ai/ha glyphosate was tank-mixed with 90 g/ha metribuzin plus 15 g/ha chlorimuron or 36 g ai/ha imazaquin. When lower rates of paraquat or glufosinate were tank-mixed with 210 g/ha metribuzin, antagonism also occurred. Less antagonism was noted with glufosinate.

Field experiments were conducted from 1993 to 1995 to compare weed control by the isopropylamine salt of glyphosate at 0.21, 0.42, 0.63, and 0.84 kg ae/ha applied at three stages of weed growth. Weed control by glyphosate applied at these rates alone or with ammonium sulfate at 2.8 kg/ha was also evaluated. In other experiments, potential interactions between glyphosate and acifluorfen, chlorimuron, and 2,4-DB were evaluated. Velvetleaf, prickly sida, sicklepod, pitted morningglory, entireleaf morningglory, palmleaf morningglory, and hemp sesbania were controlled more easily when weeds had one to three leaves compared with control when weeds had four or more leaves. Glyphosate controlled redroot pigweed, velvetleaf, prickly sida, sicklepod, and barnyardgrass more effectively than pitted morningglory, entireleaf morningglory, palmleaf morningglory, or hemp sesbania. Increasing the rate of glyphosate increased control, especially when glyphosate was applied to larger weeds. Greater variation in control was noted for pitted morningglory, palmleaf morningglory, prickly sida, and velvetleaf than for redroot pigweed, sicklepod, entireleaf morningglory, or hemp sesbania. Ammonium sulfate increased prickly sida and entireleaf morningglory control but did not influence sicklepod, hemp sesbania, or barnyardgrass control. Acifluorfen applied 3 d before glyphosate or in a mixture with glyphosate reduced barnyardgrass control compared with glyphosate applied alone. Chlorimuron did not reduce efficacy. Mixtures of glyphosate and 2,4-DB controlled sicklepod, entireleaf morningglory, and barnyardgrass similar to glyphosate alone.

In 12 trials in Louisiana, sicklepod, entireleaf morningglory, pitted morningglory, and hemp sesbania control 4 wk after planting was greater with trifluralin applied PPI followed by chlorimuron plus metribuzin applied PRE than with trifluralin plus flumetsulam applied PPI. Sicklepod control with these herbicides was similar 6 wk after application. No differences in soybean yield were noted. Chlorimuron applied POST following trifluralin applied PPI and metribuzin applied PRE or trifluralin plus flumetsulam applied PPI improved weed control and soybean yield compared with soil-applied herbicides alone. Excellent barnyardgrass control was obtained with all herbicide programs.

Broadleaf weed control with DPX-PE350 at 56, 84, 110, 140, and 170 g ae ha−1 applied postemergence was evaluated. DPX-PE350 was less effective and higher rates were required when applied to three- to six-leaf weeds compared to one- to two-leaf weeds. Listed in order of increasing susceptibility are sicklepod, tall morningglory, pitted morningglory = palmleaf morningglory, and entireleaf morningglory = hemp sesbania = velvetleaf.

Experiments conducted in North Carolina and Virginia compared weed control, peanut yield, and net returns with systems using imazethapyr applied at various times and the regional standard treatment of paraquat applied at the ground-cracking stage of peanut (GC) followed by acifluorfen plus bentazon applied POST. Imazethapyr was applied PPI, PRE, GC, or POST at 70 g ae ha−1. Imazethapyr also was applied sequentially PPI plus GC, PPI plus POST, and PRE plus POST at 35 + 35 and 70 + 70 g ha−1. Late-season control of common ragweed and a mixture of entireleaf, ivyleaf, and pitted morningglories by the standard treatment ranged from 85 to 100%. Spurred anoda was controlled 80%, and common lambsquarters and prickly sida were controlled completely. Control of common lambsquarters, prickly sida, and morningglory by imazethapyr applied one or more times was similar to control by the standard. Control by imazethapyr exceeded that by the standard only for spurred anoda. The most effective time for applying imazethapyr varied by species and locations. Imazethapyr was equally effective on common lambsquarters and spurred anoda when applied PPI, PRE, or GC. Prickly sida and morningglory were controlled best when imazethapyr was applied PPI or PRE and GC, respectively. Common ragweed was controlled poorly with single applications of imazethapyr. Applying imazethapyr sequentially improved consistency of control across the range of species. In most cases, imazethapyr applied sequentially at 35 + 35 g ha−1 controlled all weeds as well as or better than when applied once at 70 g ha−1. Overall, imazethapyr at the registered rate of 70 g ha−1 was most effective when applied PPI at 35 g ha−1 followed by 35 g ha−1 at GC. Except for common ragweed, weed control with this treatment was similar to that by the standard. Peanut yield and net returns with this treatment were similar to those with the standard at three of four locations.

Barnyardgrass and morningglory control POST with glufosinate at 840 g a.i./ha 28 d after treatment was 79 to 85% and 83 to 90%, respectively, when no more than 35 d elapsed between initial spring soil tillage and herbicide application. For the same rate of glufosinate, prickly sida and hemp sesbania were controlled 68 and 92%, respectively. Comparable barnyardgrass control was obtained with glufosinate at 560 and 840 g/ha, which was greater than at 420 g/ha. Hemp sesbania control was similar for all rates of glufosinate. In comparison, paraquat at 1050 g a.i./ha controlled 40 to 65% barnyardgrass, 44 to 75% morningglory, 41% prickly sida, and 92% hemp sesbania. With 840 g a.i./ha glyphosate and SC-0224, barnyardgrass, morningglory, prickly sida, and hemp sesbania were controlled 55 to 89%, 55 to 81%, 45 to 61%, and 56 to 68%, respectively. Soybean yield was 5.8, 7.6, 6.0, and 5.9 times greater than the nontreated check for 1050 g/ha paraquat and 840 g/ha glufosinate, glyphosate, and SC-0224, respectively.