The investigation of potential herbicides for weed control in sweetpotato is critical due to the limited number of registered herbicides and the development of populations of herbicide- resistant weeds. Therefore, field studies were conducted at the Horticultural Crops Research Station, Clinton, NC and the Pontotoc Ridge–Flatwoods Branch Experiment Station, Pontotoc, MS to determine the effect of oryzalin application rate and timing on sweetpotato tolerance. Oryzalin at 0.6, 1.1, 2.2, 3.4, and 4.5 kg ai ha–1 was applied immediately after transplanting or 14 d after sweetpotato transplanting (DAP). At Clinton, oryzalin applied immediately after transplanting resulted in ≤1% leaf distortion 4 and 6 wk after transplanting (WAP) regardless of application rate. However, when oryzalin was applied 14 DAP, greater sweetpotato leaf distortion was observed from 2.2, 3.4, and 4.5 kg ha–1 (≤8%) than 0.6 and 1.1 kg ha–1 (≤4%). At Pontotoc, oryzalin applied immediately after transplanting resulted in ≤6% leaf distortion 4 WAP regardless of application rate. However, when oryzalin was applied at 14 DAP, greater leaf distortion was reported from 3.4 and 4.5 kg ha–1 (11 to 13%) than 0.6, 1.1, and 2.2 kg ha–1 (4 to 6%). Oryzalin application rate and timing did not affect yield of no.1, jumbo, or marketable sweetpotato. Based on these results, oryzalin herbicide has potential for registration in sweetpotato.