This article examines the relationship between the International Studies Conference (ISC), the question of peaceful change, and the study of international relations (IR) in the United States. It argues that the prewar and wartime years constituted a pivotal moment in the disciplinary history of American International Relations, particularly in terms of the transformation of the field from prewar international studies into postwar IR; and that the ISC and its American committee offer a valuable vantage point for observing the dynamics and stakes involved in this transformation. The growing urgency of peaceful change during the 1930s imbued the ISC and its American committee with unprecedented significance for U.S. scholars in the field, promoting in the process a framework for international studies that favoured international and interdisciplinary collaboration as well as multi-conceptual perspectives. Disappointment with the results of ISC deliberations on peaceful change, however, undermined the ISC-associated framework, boosting in the process another framework centred in and on the United States as well as on ‘power politics’. The growing ascendency of this second framework would mark IR in the United States, providing fertile terrain for the postwar emergence of realism.