North America was a key nineteenth-century battleground for indigenous rights. The Aborigines’ Protection Society followed US developments keenly; derided and despaired of the rule of the monopolistic Hudson’s Bay Company in Rupert’s Land; and hoped that the Canadian colonies could lead the way in recognizing indigenous rights. This chapter considers the society’s championing of indigenous rights in British North America at a time of imperial withdrawal. It explores the emphasis placed by the Aborigines’ Protection Society on ‘civilization’, and how this was shaped by Thomas Hodgkin’s encounters with four indigenous activists from British North America. The Ojibwa chief and missionary, the Reverend Peter Jones and his niece, Nahnebahwequa, protested the theft of their land and advocated for indigenous education, representation and legal rights. Alexander Isbister and his uncle, William Kennedy, spearheaded the campaign in Britain against the Hudson’s Bay Company. The chapter explores how indigenous interlocutors’ engaged with British humanitarians; how their authority translated to the metropolitan context; and how this translation jeopardized standing at home.