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1 results

  • Developing a potent vaccine against Helicobacter pylori: critical considerations and challenges

  • Faria Hasanzadeh Haghighi, Shaho Menbari, Roghayeh Mohammadzadeh, Abbas Pishdadian, Hadi Farsiani
  • Journal:
    Expert Reviews in Molecular Medicine / Volume 27 / 2025
    Published online by Cambridge University Press:
    25 November 2024, e12
    • Article
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  • Helicobacter pylori (H. pylori) is closely associated with gastric cancer and peptic ulcers. The effectiveness of antibiotic treatment against H. pylori is diminished by the emergence of drug-resistant strains, side effects, high cost and reinfections. Given the circumstances, it is imperative to develop a potent vaccination targeting H. pylori. Understanding H. pylori’s pathogenicity and the host’s immune response is essential to developing a vaccine. Furthermore, vaccine evaluation necessitates the careful selection of design formulation. This review article aims to provide a concise overview of the considerations involved in selecting the optimal antigen, adjuvant, vaccine delivery system and laboratory animal model for vaccine formulation. Furthermore, we will discuss some significant obstacles in the realm of developing a potent vaccination against H. pylori.