In the late eighteenth century, Johann David Michaelis criticized Moses Mendelssohn for bringing what Michaelis termed his native Jewish tradition into his thinking on universal matters. Yet leaning on Jewish sources had been a key feature of European natural law thinking from the onset of modernity. In this article, the author reads Mendelssohn’s natural law theory as conversant with early modern legal thought that was scrutinized in the enlightenment, shedding new light on Mendelssohn’s innovations and on what Mendelssohn was up against when he offered natural law foundations for toleration. The author finds that arguments for and against toleration of the Jews from the seventeenth century to the nineteenth were tied to the question of whether Judaism contained universal laws or laws particular to the Jews, and suggests that Mendelssohn’s approach, while rejected from the eighteenth to the twentieth century, may be newly relevant today.