We measure the flux values in the 4 Spitzer-IRAC bands, of a sample of 78 isolated luminous HII regions in the grand design galaxy M100. We estimate the near-IR luminosities and compare them with the Hα-luminosities from the Knapen HII-region catalogue. We find a strong, and expected positive correlation between the total IR luminosity and the Hα luminosity, but no significant correlation between the luminosity and the IR temperature of the regions.