Before 1898, the most sustained attempt by the United States to acquire Cuba occurred during the presidency of Franklin Pierce when the debate about slavery was roiling US domestic politics. Spain responded to the threat with a dramatic change of policy: in order to gain the favour and protection of Britain, it ordered that the slave trade to Cuba be ended. This article analyses Pierce's strategy and examines the complex jockeying it precipitated among Washington, London and Madrid. Mining US, British and Spanish archives, it is the first international history of the crisis that Washington's avarice provoked.