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1 results

  • Reversible complete atrioventricular block in a neonate with maternal anti-Sjögren’s syndrome-associated antibody: atypical phenotype of autoimmune congenital heart block

  • Hirofumi Saiki, Kanchi Saito, Akira Sato
  • Journal:
    Cardiology in the Young / Volume 33 / Issue 11 / November 2023
    Published online by Cambridge University Press:
    19 July 2023, pp. 2430-2433
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  • The fetus of anti-Sjögren’s syndrome-associated antibody-positive mother developed complete atrioventricular block at 39 weeks of gestation and required urgent ventricular pacing after birth. Unexpectedly, the patient recovered from the atrioventricular block within a few days. Fraction analysis of maternal anti-Sjögren’s syndrome-associated antibody revealed positivity for isolated anti-Ro/SSA 60 kDa antibody, which is abnormal as most patients with complete atrioventricular block present with anti-Ro/SSA 52 kDa positivity, which may indicate a potentially atypical late and reversible manifestation of an autoimmune congenital atrioventricular block in this patient.