The Paracas culture of Late Formative Period south coastal Peru (c. 900–100 BC) is renowned for its elaborate and colourful ceramics—particularly those decorated using the post-fire painting technique. The materials and the methods used to achieve post-fire painting, however, remain elusive. To investigate the evolution of, and regional variation in, this technology, the authors deploy a range of techniques to analyse a sample of Paracas ceramics curated in museum collections. The results indicate diachronic and regional variations in the paint binders and colourants used by the Paracas potters, which correlate with changes in vessel form and iconography over time.