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1 results

  • Selegiline in Patients With Disorder of Consciousness: An Open Pilot Study

  • Orsola Masotta, Luigi Trojano, Vincenzo Loreto, Pasquale Moretta, Anna Estraneo
  • Journal:
    Canadian Journal of Neurological Sciences / Volume 45 / Issue 6 / November 2018
    Published online by Cambridge University Press:
    15 November 2018, pp. 688-691
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  • This open study investigated the clinical effects of 10-week selegiline administration in six patients in vegetative state and in four patients in a minimally conscious state, at least 6 months after onset. Clinical outcome was assessed by Coma Recovery Scale-Revised once a week during selegiline administration and 1 month later. Three patients stopped treatment because of possible side effects. After treatment and at 1 month of follow-up, four patients showed improvements in clinical diagnosis, and three patients showed an increase in arousal level only. Selegiline might represent a relatively safe option to enhance arousal and promote recovery in brain-injured patients with disorders of consciousness.