The exotic plant, swallow-wort, a twining perennial of the Milkweed family, has become increasingly invasive in natural areas, successional old fields, and tree plantations on calcareous soils of the lower Great Lakes basin. Because mechanical control strategies are inadequate, swallow-wort's response in natural areas to foliar spray and cut-stem applications of glyphosate and triclopyr was evaluated. Foliar spray applications of glyphosate (3.1 and 7.8 kg ae ha–1) and triclopyr (1.9 kg ae ha–1) were more effective than cut-stem applications of the herbicides (3.1 kg ae ha–1 glyphosate, 1.4 kg ae ha–1 triclopyr). There were no statistical differences in effect among the foliar spray applications. Response to cut-stem application of glyphosate (3.1 and 6.2 kg ha–1) and triclopyr (1.4, 2.8, and 5.6 kg ha–1) in the following year indicated glyphosate to be more effective than triclopyr at all concentrations tested. To effect long-lasting control, all treatments require additional herbicide application.