Greenhouse studies were conducted in 2012 in Raleigh, NC to determine Carolina redroot control by ten POST herbicides. Paraquat and glufosinate provided the greatest control 14 (73 and 64%, respectively) and 25 d (82 and 68%, respectively) after treatment (DAT), but control declined between 25 and 63 DAT (72 and 59%, respectively). Glyphosate provided minimal control 14 DAT (18%), and control increased from 14 to 25 DAT (46%) and 25 to 63 DAT (69%). Control of Carolina redroot roots and rhizomes (roots/rhizomes) was greatest in plants treated with paraquat (91%), glyphosate (88%), glufosinate (73%), hexazinone (62%), diuron (60%). Nontreated Carolina redroot shoot and root/rhizome dry weight were 8.3 and 7.6 g, respectively. Paraquat, glufosinate, glyphosate, and diuron reduced both shoot and root/rhizome dry weight (3.1 and 0.7 g, 5.1 and 2.7 g, 5.4 and 1.0, 5.7 and 1.6 g, respectively). Hexazinone reduced root/rhizome dry weight (2.7 g). Fomesafen reduced shoot dry weight (6.1 g), but did not reduce root/rhizome dry weight. Paraquat, glufosinate, glyphosate, hexazinone, diuron, and clopyralid treatments resulted in reduced incidence of Carolina redroot flowering and anthesis.