In the present work, a novel multistrip monopole antenna fed by a cross-shaped stripline comprising one vertical and two horizontal strips has been proposed for wireless local area network (WLAN)/Industrial, Scientific, and Medical band (ISM)/International Mobile Telecommunication (IMT)/BLUETOOTH/Worldwide Interoperability for Microwave Access (WiMAX) applications. The designed antenna has a small overall size of 20 × 30 mm2. The goal of this paper is to use defected ground structure (DGS) in the proposed antenna design to achieve dual-band operation with appreciable impedance bandwidth at the two operating modes satisfying several communication standards simultaneously. The antenna was simulated using Computer Simulation Technology Microwave Studio (CST MWS) V9 based on the finite integration technique (FIT) with perfect boundary approximation. Finally, the proposed antenna was fabricated and some performance parameters were measured to validate against simulation results. The design procedure, parametric analysis, simulation results along with measurements for this multistrip monopole antenna using DGS operating simultaneously at WLAN (2.4/5.8 GHz), IMT (2.35 GHz), BLUETOOTH (2.45 GHz), and WiMAX (5.5 GHz) are presented.