Corticobasal degeneration (CBD) is a neurodegenerative disease characterized by abnormal aggregation of hyperphosphorylated 4R-tau in cortical and subcortical areas of the brain. It is associated with various clinical phenotypes, such as the characteristic clinical phenotype corticobasal syndrome (CBS), which manifests with asymmetric akinetic–rigid, poorly levodopa-responsive parkinsonism, and cerebral cortical dysfunction. Other associated phenotypes are progressive supranuclear palsy (PSP) syndrome, frontotemporal dementia, Alzheimer’s disease (AD)-like dementia, and non-fluent/agrammatic variant of primary progressive aphasia. Precise use of terminology is critical for a common understanding in discussions of clinical phenotype, attempted clinical diagnosis of CBD with its many presenting phenotypes, and accurate pathologic diagnosis (which can only be made neuropathologically). Diagnosis of probable or possible CBS and the other CBD-associated syndromes is based on the presence of certain clinical features. Pathologic and neuroimaging findings and currently available biological markers are discussed. Treatment for CBD and CBS is symptomatic and supportive at present.

The growth of Bernstein’s career coincided with the growth of television, so many knew him through his broadcasts. His fifty-three hour-long award-winning Young People’s Concerts (1958−72) are among his most significant television work and were seen at their height by nearly ten million in the USA and in over forty countries. In each show, the maestro would expound on some musical principle, with clarity and appeal, accompanied by demonstrations by him and the New York Philharmonic. While the series clearly shows Bernstein’s brilliant pedagogy, a deeper story lies beneath. No other musician in the late twentieth century so fully addressed the issues of the day as did Bernstein, and no other classical musician has ever been so widely seen. Through his Young People’s Concerts, the maestro not only spread his love of music but also raised his artistic voice from this bully pulpit to work for a better world.