While many sociological studies analyze the causes, conditions, and mechanisms perpetuating American racial inequality, the literature on how African Americans understand and explain these inequalities is less developed. Drawing on 150 interviews with middle-class and working-class African American men and women, this paper analyzes inductively how respondents define and conceptualize the most pressing obstacles facing their group when probed on this question. We find that middle- and working-class respondents alike identify the problem of racism as the most salient obstacle facing African Americans. Class differences appear with respect to what other obstacles are singled out as salient: while middle-class respondents focus on lack of racial solidarity among Blacks and economic problems (in this order), working-class respondents are more concerned with the fragility of the Black family followed by the lack of racial solidarity. This analysis discusses the relevance of considering how groups make sense of obstacles, and of racism and discrimination in particular, for the study of destigmatization and antiracist strategies of stigmatized minorities.