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Thrombophilia can be defined as laboratory abnormalities, usually in the coagulation system, that result in a hypercoagulable state and thus predispose to thrombosis. These abnormalities may be acquired or inherited. The most clearly established form of acquired thrombophilia is the antiphospholipid anti- body syndrome. This chapter focuses on inherited thrombophilia. The relevance of inherited thrombophilia in early pregnancy is manifested in an elevated risk of venous thromboembolism, a modestly increased risk of miscarriage, and a possible relation with fertility.
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