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Already at a young age, Strauss made initial contacts with well-known publishing houses. Eugen Spitzweg of the Munich publishing house Jos. Aibl became a paternal friend for the aspiring composer. At the beginning, when Strauss was barely known to a wide audience, Spitzweg expressed his friendship by including Strauss’s compositions in his catalog. But soon Strauss’s reputation grew – and with it his self-confidence in negotiations with his business partners. Unlike some other important composers in music history, Strauss developed into a capable businessman and secured high fees for his music. This chapter highlights the publishing context of Strauss’s work. It characterizes his relationships with his long-time main publishers, names the publishers with whom Strauss collaborated only briefly, and presents an overview of the great variety of sheet music editions (from historical publications to modern critical editions) in which Strauss’s music is available.
The Australian Imaging, Biomarkers and Lifestyle (AIBL) Flagship Study of Ageing is a prospective study of 1,112 individuals (211 with Alzheimer's disease (AD), 133 with mild cognitive impairment (MCI), and 768 healthy controls (HCs)). Here we report diagnostic and cognitive findings at the first (18-month) follow-up of the cohort. The first aim was to compute rates of transition from HC to MCI, and MCI to AD. The second aim was to characterize the cognitive profiles of individuals who transitioned to a more severe disease stage compared with those who did not.
Methods:
Eighteen months after baseline, participants underwent comprehensive cognitive testing and diagnostic review, provided an 80 ml blood sample, and completed health and lifestyle questionnaires. A subgroup also underwent amyloid PET and MRI neuroimaging.
Results:
The diagnostic status of 89.9% of the cohorts was determined (972 were reassessed, 28 had died, and 112 did not return for reassessment). The 18-month cohort comprised 692 HCs, 82 MCI cases, 197 AD patients, and one Parkinson's disease dementia case. The transition rate from HC to MCI was 2.5%, and cognitive decline in HCs who transitioned to MCI was greatest in memory and naming domains compared to HCs who remained stable. The transition rate from MCI to AD was 30.5%.
Conclusion:
There was a high retention rate after 18 months. Rates of transition from healthy aging to MCI, and MCI to AD, were consistent with established estimates. Follow-up of this cohort over longer periods will elucidate robust predictors of future cognitive decline.
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