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étiopathogénie des maladies mentales

Psychiatry and Psychobiology (1)

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Génétique et psychiatrie : une nouvelle approche de l’étiopathogénie des maladies mentales ?
M. Leboyer, F. Clerget-Darpoux
Journal:

Psychiatry and Psychobiology / Volume 3 / Issue 2 / 1988

Published online by Cambridge University Press:

28 April 2020, pp. 69-72

Print publication:

1988
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Jusqu’à présent, différentes méthodes ont été utilisées pour mettre en évidence l’influence de facteurs de risque d’origine génétique: comparaison du taux de concordance chez des jumeaux monozygotes et dizygotes, études d’adoption, analyse de ségrégation et analyse de linkage. Le développement explosif de la biologie moléculaire, fournissant un nombre grandissant de marqueurs génétiques, rend particulièrement prometteuse l’application des techniques de linkage. Néanmoins, il faut être conscient que l’application de cette stratégie aux maladies psychiatriques se heurte à des difficultés spécifiques: critères diagnostiques, âge de début variable, hétérogénéité probable, corrélations intrafamiliales environnementales.