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Rasch modeling of IQCODE scores in people with dementia

Published online by Cambridge University Press:  17 August 2022

Gerard J. Byrne*
Affiliation:
Academy of Psychiatry, Faculty of Medicine, University of Queensland, Herston, QLD 4006, Australia Mental Health Centre, Royal Brisbane & Women’s Hospital, Herston, QLD 4029, Australia
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Abstract

Type
Commentary
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of International Psychogeriatric Association

The Informant Questionnaire for Cognitive Decline in the Elderly (IQCODE; Jorm and Jacomb, Reference Jorm and Jacomb1989) is an informant-rated instrument which is useful in situations in which the person being assessed for cognitive impairment is unable or unwilling to undergo cognitive testing, or where there may be a question about the validity of cognitive testing. Its performance as a screening tool is comparable to that of cognitive screening tests such as the Mini-Mental State Examination). Limitations on face-to-face consultations during the COVID-19 pandemic have opened up another use for the IQCODE as an adjunct to telephone testing methods such as the Telephone Interview for Cognitive Status-Modified (Brandt et al., Reference Brandt, Welsh, Breitner, Folstein, Helms and Christian1993).

The IQCODE has been validated against other measures of cognitive change (Jorm et al., Reference Jorm, Christensen, Henderson, Jacomb, Korten and Mackinnon1996), clinical diagnosis (Jorm, Reference Jorm2004; van Nieuwkerk et al., Reference Van Nieuwkerk, Pendlebury and Rothwell2021), brain autopsy findings (Rockwood et al., Reference Rockwood1998), neuroimaging findings (Cordoliani-Markowiak et al., Reference Cordoliani-Mackowiak, Henon, Pruvo, Pasquier and Leys2003), incident dementia (Louis et al., Reference Louis, Harwood, Hope and Jacoby1999), and mortality (Jorm, Reference Jorm2004). It has also been the subject of a Cochrane review (Quinn et al., Reference Quinn, Fearon, Noel-Storr, Young, McShane and Stott2021).

The original IQCODE has 26 items, and the Short IQCODE (also known as IQCODE-16) has 16 items (Jorm, Reference Jorm1994). Each item is rated on a 5-point Likert scale from “Much improved” (1) to “Much worse” (5). For example, “Recalling conversations a few days later” is item 5 on the IQCODE and item 3 on the Short IQCODE. The informant is asked to rate how the person is now in comparison with how they were 10 years ago. Both major forms of the IQCODE are available in multiple languages and can be used without a licence fee. The Short IQCODE has been reported to be correlated 0.98 with the original version (Jorm, Reference Jorm2004), and it is now in widespread use.

In clinical use, the standard method of calculating a total score involves dividing the summed item scores by either 26 for the IQCODE or by 16 for the Short IQCODE. This method generates a score out of 5, with higher scores indicating greater cognitive decline over the previous 10 years. When screening for dementia, the developers have recommended using cutting points on the IQCODE of 3.27/3.30 and on the Short IQCODE of 3.31/3.38, whereas other researchers have proposed cutting points between 3.27 and 4.00 (Jorm, Reference Jorm2004). The thresholds for detecting clinically significant cognitive decline vary by the prior probability of cognitive impairment in the population under test (e.g., memory clinic attendees versus population samples), but are straightforward to apply.

The clinical utility of the IQCODE depends critically upon the availability of a suitable informant, who needs to have known the patient for the previous 10 years. It also relies upon truth telling by the informant, so is likely to have limitations in both civil and criminal medicolegal assessments. It may be influenced more generally by the response style of the informant and by the demand characteristics of the assessment situation, including social desirability. The IQCODE does not substitute for detailed clinical history-taking because it does not provide information about clinical course or trajectory, and it is silent as to etiology.

A potential problem with the IQCODE Likert scores is that the individual items may not be of equivalent “difficulty” and as a consequence the summed scores form an ordinal scale rather than a linear one (Boone, Reference Boone2016). The Rasch model provides a mathematical method for dealing with this problem. Rasch analysis, named for Danish mathematician Georg Rasch, employs a statistical approach that is most often applied to categorical or ordinal data, including data from questionnaires. The Rasch model seeks to capture the trade-off between item difficulty and respondent ability and can be understood as a special case of item response theory (Raykov and Marcoulides, Reference Raykov and Marcoulides2018). A polytomous Rasch model can be applied to Likert scales that measure a characteristic or ability using successive integers. Rasch models allow such nonlinear data to be converted into linear form, allowing interrogation using parametric statistics (Boone, Reference Boone2016). Linear transformation has advantages for psychometric scale development and subsequent modification, as well as in research applications.

Against this background, Truong et al. (Reference Truong2021) applied Rasch analysis to Short IQCODE data from the Memory and Ageing Study (MAS). The MAS is a longitudinal observational study based on a sample of nondemented community-residing individuals aged 70–90 years at enrolment drawn from the electoral rolls of the eastern suburbs of Sydney, Australia. The sample was of homogeneous white European ethnicity and at baseline participants lived mainly in private dwellings. The MAS participants have been seen biennially and extensively investigated (Sachdev et al., Reference Sachdev2010).

From 1,037 MAS participants, Truong et al. (Reference Truong2021) identified 400 for Rasch analysis. These included 109 participants with dementia at Wave 6 and a random sample of 291 from the 814 participants who did not have dementia at Wave 6. They combined 10 locally dependent Short IQCODE items into five “super-items” to improve the fit of the model and then identified the best model that allowed conversion of raw ordinal data into interval-level data. They found a small but statistically significant difference between the ordinal raw scores and the interval-level Rasch scores. The mean Rasch score was slightly higher than the mean raw score, and a conversion table was provided. The interval-level Rasch scores were independent of the informant’s gender, age, and relationship to the MAS participant. The authors acknowledged that their MAS sample lacked ethnic diversity, was recruited from an affluent area of Sydney, and may not generalize well to other older adults.

From a pragmatic perspective, a typical Short IQCODE mean score of, say, 4.00 in a person with cognitive impairment seen in a memory clinic would correspond to an MAS raw ordinal score of 64 and an MAS Rasch interval-level score of 64.96. As a regular user of the Short IQCODE, I doubt a difference of this magnitude would alter my clinical decision making. However, in conducting research using the Short IQCODE, I would be happy to employ the interval-level data generated through Rasch analysis.

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