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Additive effects of a family history of schizophrenia spectrum disorders and an environmental risk score for the outcome of patients with non-affective first-episode psychosis

Published online by Cambridge University Press:  20 March 2024

Manuel J. Cuesta Open the ORCID record for Manuel J. Cuesta [Opens in a new window] ,
Elena García de Jalón ,
Ana M. Sánchez-Torres ,
Gustavo J. Gil-Berrozpe ,
Lidia Aranguren ,
Gerardo Gutierrez ,
Asier Corrales ,
Amalia Zarzuela ,
Berta Ibañez  and
Víctor Peralta
...Show all authors
Manuel J. Cuesta*
Affiliation:
Department of Psychiatry, Hospital Universitario de Navarra, Pamplona, Spain Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
Elena García de Jalón
Affiliation:
Navarra Institute for Health Research (IdiSNA), Pamplona, Spain Mental Health Department, Servicio Navarro de Salud – Osasunbidea, Pamplona, Spain
Ana M. Sánchez-Torres
Affiliation:
Navarra Institute for Health Research (IdiSNA), Pamplona, Spain Departament of Health Sciences, Universidad Pública de Navarra (UPNA), Pamplona, Spain
Gustavo J. Gil-Berrozpe
Affiliation:
Department of Psychiatry, Hospital Universitario de Navarra, Pamplona, Spain Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
Lidia Aranguren
Affiliation:
Navarra Institute for Health Research (IdiSNA), Pamplona, Spain Mental Health Department, Servicio Navarro de Salud – Osasunbidea, Pamplona, Spain
Gerardo Gutierrez
Affiliation:
Navarra Institute for Health Research (IdiSNA), Pamplona, Spain Mental Health Department, Servicio Navarro de Salud – Osasunbidea, Pamplona, Spain
Asier Corrales
Affiliation:
Navarra Institute for Health Research (IdiSNA), Pamplona, Spain Mental Health Department, Servicio Navarro de Salud – Osasunbidea, Pamplona, Spain
Amalia Zarzuela
Affiliation:
Navarra Institute for Health Research (IdiSNA), Pamplona, Spain Mental Health Department, Servicio Navarro de Salud – Osasunbidea, Pamplona, Spain
Berta Ibañez
Affiliation:
Navarra Institute for Health Research (IdiSNA), Pamplona, Spain Methodology Unit, Navarrabiomed – HUN – UPNA, RICAPPS, Pamplona, Spain
Víctor Peralta
Affiliation:
Navarra Institute for Health Research (IdiSNA), Pamplona, Spain Mental Health Department, Servicio Navarro de Salud – Osasunbidea, Pamplona, Spain
*
Corresponding author: Manuel J. Cuesta; Email: [email protected]
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Abstract

Background:

First-episode psychotic disorders comprise a heterogeneous phenotype with a complex etiology involving numerous common small-effect genetic variations and a wide range of environmental exposures. We examined whether a family of schizophrenia spectrum disorder (FH-Sz) interacts with an environmental risk score (ERS-Sz) regarding the outcome of patients with non-affective first episode psychosis (NAFEP).

Methods:

We included 288 patients with NAFEP who were evaluated after discharge from an intensive 2-year program. We evaluated three outcome measures: symptomatic remission, psychosocial functioning, and personal recovery. We analyzed the main and joint associations of a FH-Sz and the ERS-Sz on the outcomes by using the relative excess risk due to interaction (RERI) approach.

Results:

A FH-Sz showed a significant association with poor symptomatic remission and psychosocial functioning outcomes, although there was no significant interaction between a FH-Sz and the ERS-Sz on these outcomes. The ERS-Sz did not show a significant association with poor symptomatic remission and psychosocial functioning outcomes, even though the magnitude of the interaction between ERS-Sz and FH-Sz with the later outcome was moderate (RERI = 6.89, 95% confidence interval −16.03 to 29.81). There was no association between a FH-Sz and the ERS-Sz and personal recovery.

Conclusions:

Our results provide further empirical support regarding the contribution of FH-Sz to poor symptomatic remission and poor psychosocial functioning outcomes in patients with NAFEP.

Keywords

environmental risk scorefamily of schizophrenia spectrum disorderfirst-episode psychosisnon-affective psychosisRERI
Type
Original Article
Information
Psychological Medicine , Volume 54 , Issue 10 , July 2024 , pp. 2435 - 2443
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Copyright
Copyright © The Author(s), 2024. Published by Cambridge University Press.

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Footnotes

*

PEPsNa GROUP: Matilde Martínez, María Otero, Mari Cruz Ariz, Ainhoa Aquerreta, Leire Azcárate, Nahia Pereda, Fernando Monclús, Laura Moreno, Alba Fernández, Alba Sabaté, Izaskun Aguirre, Tadea Lizarbe, Myriam Ochoa Martínez and Maria Jose Begué.

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