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The South Korean Twin Registry

Published online by Cambridge University Press:  26 December 2019

Yoon-Mi Hur ,
Man Chull Kang ,
Hoe-Uk Jeong ,
Il Cook Kang  and
Jong Woo Kim
Yoon-Mi Hur*
Affiliation:
Institute for Education Research, Department of Education, Mokpo National University, Jeonnam, South Korea
Man Chull Kang
Affiliation:
Institute for Education Research, Department of Education, Mokpo National University, Jeonnam, South Korea
Hoe-Uk Jeong
Affiliation:
Institute for Education Research, Department of Education, Mokpo National University, Jeonnam, South Korea
Il Cook Kang
Affiliation:
Institute for Education Research, Department of Education, Mokpo National University, Jeonnam, South Korea
Jong Woo Kim
Affiliation:
Department of Neuropsychiatry, Kyung Hee University, Seoul, South Korea
*
Author for correspondence: Yoon-Mi Hur, Email: [email protected]

Abstract

The South Korean Twin Registry (SKTR) is an ongoing nationwide volunteer registry of South Korean twins and their families. Since its inception, from preschooler to young adult, twins have been registered with the SKTR and have demonstrated that relative influences of genetic and environmental factors explaining individual differences in various psychological, mental health and physical traits in South Koreans are similar to those found in many Western twin studies. Currently, studies at the SKTR focus on identification of the process of gene-by-environment interactions as well as developmental differences in genetic and environmental influences on psychological and mental health traits in South Koreans. This report provides a brief overview, recruitment strategies, current samples, zygosity assessment, measures and future directions of the SKTR.

Keywords

South Korea Twin Registrydevelopmentpsychological traitsmental health
Type
Articles
Information
Twin Research and Human Genetics , Volume 22 , Special Issue 6: Twin family registries worldwide: An important resource for scientific research , December 2019 , pp. 606 - 608
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Creative Common License - CCCreative Common License - BYCreative Common License - NCCreative Common License - ND
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Copyright
© The Author(s) 2019

The South Korean Twin Registry (SKTR) is an ongoing nationwide volunteer registry of South Korean twins and their families. The general goal of the SKTR is to understand the interplay of genetic and environmental influences on psychological and mental health traits in South Koreans. Since its inception, multiple cross-sectional twin studies that span preschool age to early adulthood have been conducted (Hur, Reference Hur2002; Hur et al., Reference Hur, Shin, Jeong and Han2006, Reference Hur, Jeong, Chung, Shin and Song2013). Relative influences of genetic and shared environmental factors in many psychological, mental health and physical traits found in these studies were similar to those reported in Western twin samples, although absolute phenotypic, genetic and environmental variances were found to be different to those discovered in Western samples (Hur et al., Reference Hur, Kaprio, Iacono, Boomsma, McGue, Silventoinen and Mitchell2008), suggesting that further analyses are necessary to determine genetic and environmental etiologies of variations across human populations. Current major research issues of the SKTR include detection of environmental variables that interact with genetic factors as well as identification of the process of gene-by-environment interaction in psychological and mental health in children and adolescents. Recently, we have also begun exploring genetic influences on mental health unique to South Koreans, such as hwabyung (anger syndrome), which most Korean mental health professionals and the layperson have assumed to be environmental in origin (Hur, Choi et al., Reference Hur, Choi, Kim, Jin and Lee2018; Hur, Jin, Lee, et al., Reference Hur, Jin, Lee and Kim2019. The SKTR has been a partner contributing to the international consortiums such as the Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins (CODATwins; Silventoinen et al., Reference Silventoinen, Jelenkovic, Yokoyama, Sund, Sugawara, Tanaka and Kaprio2019) and is ready to serve as other international collaborations to identify genetic and environmental origins of human psychological and health traits.

Recruitment Strategies

We identify twins mainly from schools, large maternity hospitals and the websites of the twins’ mothers’ clubs throughout South Korea. We ask city and provincial education offices to send our invitation letters to each school to obtain contact information (typically, telephone number) of twins interested in participation in our research. In addition, we obtain contact information about mothers of twins from large maternity hospitals. Once we receive contact information, our trained research staff telephone twins or mothers of twins, explain our research in detail and then give telephone interviews. We also advertise our research on the websites of twins’ mothers’ clubs. Typically, we attach online questionnaires to the websites and ask mothers of twins to complete the questionnaire online.

Sample and Zygosity Assessment

Table 1 presents the number of individual twins who have been participated in studies of the SKTR by age group and zygosity. Because residents in large cities in South Korea move around quite often, we have lost the contact information of twins during the past years. To supplement the registry membership, however, we have recruited new volunteer twins whenever fund is available.

Table 1. Number a of twins participated in studies of the South Korean Twin Registry by age group and zygosity

Note: MZ = monozygotic twins; DZ = dizygotic twins.

a Number of twin individuals.

b Opposite-sex DZ are included.

While opposite-sex twins in the SKTR are automatically assigned to dizygotic (DZ) twins, same-sex twins complete a three-item zygosity questionnaire to determine their zygosity. For twins under age 13, we ask mothers of twins to complete the zygosity questionnaire, whereas for twins aged 13 years or older, we ask twins to complete the zygosity questionnaire. For preschool-aged twins ascertained from maternity hospitals, information on chorionicity of twins is additionally used to determine zygosity. As indicated in Table 1, while monozygotic (MZ) twins outnumbered DZ twins in both the school-aged and young adult groups, the number of DZ twins is much greater than MZ twins in the preschooler group, which reflects recent changes of DZ twin birth rates in South Korea (Hur & Kwon, Reference Hur and Kwon2005; Hur & Song, Reference Hur and Song2009).

Measures

The instruments used for studies of the SKTR have been selected for their high psychometric properties and compatibilities with other twin studies in the world. Assessment categories of the SKTR include childhood temperament, personality, cognitive abilities, problem behaviors and mental health, family physical and psychological environment, and physical traits. To measure childhood temperament, the Emotionality, Activity, and Sociability scale (Buss & Plomin, Reference Buss and Plomin1984) has been used for mothers of preschooler twins (Hur, Reference Hur2009a; Veselka et al., Reference Veselka, Schermer, Just, Hur, Rushton, Jeong and Vernon2012). The Eysenck Personality Scale (Eysenck & Eysenck, Reference Eysenck and Eysenck1991), grit (Duckworth & Quinn, Reference Duckworth and Quinn2009) and economic behavior have been used with adolescent and young adult twins for personality assessment (Hur, Reference Hur2007a; Hur et al., Reference Hur, Jeong, Schermer and Rushton2011; Rushton et al., Reference Rushton, Ann Bons and Hur2008, Reference Rushton, Ann Bons, Ando, Hur, Irwing, Vernon and Barbaranelli2009). The Standard Progressive Matrices-Plus version (Raven, Reference Raven2008) has been used for assessment of cognitive abilities for school-aged twins. To measure problem behaviors and mental health traits, the Strengths and Difficulties Questionnaire (Goodman, Reference Goodman1997), hostility (Koskenvuo et al., Reference Koskenvuo, Kaprio, Rose, Kesaniemi, Sara and Heikkila1988), Launey–Slade Hallucination Scale – Revised (Launay & Slade,Reference Launay and Slade1981), clinical symptoms of Personality Assessment Inventory (Morey, Reference Morey1991), Center for Epidemiological Studies-Depression scale (Radloff, Reference Radloff1977), and Maudsley Obsessive-Compulsive Inventory (Hodgson & Rachman, Reference Hodgson and Rachman1977), and hwabyung (anger syndrome), have been administered to adolescent and young adult twins (Hur, Reference Hur2006, Reference Hur2007b, Reference Hur2008, Reference Hur2009b, Reference Hur2014, Reference Hur2015; Hur et al., Reference Hur, Hwang and Chung2015; Hur, Cherny et al., Reference Hur, Cherny and Sham2012; Hur, Choi et al., Reference Hur, Choi, Kim, Jin and Lee2018; Hur & Jeong, Reference Hur and Jeong2008; Hur, Jin, Lee et al., Reference Hur, Jin, Lee and Kim2019; Hur & Rushton, Reference Hur and Rushton2007). To assess physical and psychological family environment, the Family Asset Questionnaire and the Family Adaptability and Cohesion Scale (Olson et al., Reference Olson, Portner and Lavee1985) have been administered to twins or parents of twins. For physical traits, height, weight, birth weight and Sasang constitution types have been obtained either through parental report or self-report for most twins. In addition, pubertal timing (Hur, Reference Hur2007c; Hur, Jin, & Lee, Reference Hur, Jin and Lee2019; Hur, Lee, & Jin, Reference Hur, Lee and Jin2018; Hur & Shin, Reference Hur and Shin2008; Hur et al., Reference Hur, Luciano, Martin, Boomsma, Iacono, McGue and Han2005, Reference Hur, Kaprio, Iacono, Boomsma, McGue, Silventoinen and Mitchell2008) and cold hands symptoms (Hur, Chae et al., Reference Hur, Chae, Kim, Jeong, Kim, Seo and Kim2012; Hur, Jin et al., Reference Hur, Jin and Lee2018; Hur, Yu et al., Reference Hur, Yu, Jin and Lee2018) have been collected from adolescent and young adult twins.

Future Directions

To date, the vast majority of twin studies have been conducted in Australia, Europe and the USA, although more recently, they have been extended to non-Western countries. As one of only several twin registries in Asia, the SKTR has published over 50 research papers in international scientific journals, enhancing our understanding of human population differences and similarities in genetic architectures of complex traits.

Traditionally, twins were uncommon in South Korea (Hur & Kwon, Reference Hur and Kwon2005). However, recently, the DZ twin birth rates have increased very sharply in South Korea due to the widespread use of artificial reproductive technology (Hur & Song, Reference Hur and Song2009). We thus have the potential to add a substantial number of new twins each year to the registry. In the future, we plan to investigate how genetics exert their influences on treatment outcomes and effects of intervention in problem behaviors and mental health traits in South Koreans. Additionally, efforts will be made to identify polymorphisms associated with the psychological and mental health traits in South Koreans.

Acknowledgements

We would like to thank twins and their families and many research assistants who participated in the SKTR. The SKTR has been supported by National Research Foundation grants in Korea (NRF-2001-041-C00548, NRF-2008-327-B00003, NRF-2011-371-B00047), Pioneer Fund (USA) and Korea Institute of Oriental Medicine (K18092; K18095).

References

Buss, A. H., & Plomin, R. (1984). Temperament: Early developing personality traits. Hillsdale, NJ: Erlbaum.Google Scholar
Duckworth, A. L., & Quinn, P. D. (2009). Development and validation of the Short Grit Scale (GfRIT–S). Journal of Personality Assessment, 91, 166–174.CrossRefGoogle Scholar
Eysenck, H. J., & Eysenck, S. B. G. (1991). Manual of the Eysenck personality scales. London: Hodder & Stoughton.Google Scholar
Goodman, R. (1997). The strengths and difficulties questionnaire: A research note. Journal of Child Psychology and Psychiatry, 38, 581–586.CrossRefGoogle ScholarPubMed
Hodgson, R. J., & Rachman, S. (1977). Obsessional-compulsive complaints. Behavior Research and Therapy, 15, 389–395.CrossRefGoogle ScholarPubMed
Hur, Y.-M. (2002). Seoul twin family study: Design, sampling, assessments, and future directions. Twin Research, 5, 389–393.CrossRefGoogle ScholarPubMed
Hur, Y.-M. (2006). Nonadditive genetic effects on hostility in South Korean adolescent and young adult twins. Twin Research and Human Genetics, 9, 637–654.CrossRefGoogle ScholarPubMed
Hur, Y.-M. (2007a). Evidence for nonadditive genetic effects on Eysenck Personality Scales in South Korean twins. Twin Research and Human Genetics, 10, 373–378.CrossRefGoogle ScholarPubMed
Hur, Y.-M. (2007b). Effects of the chorion type on prosocial behavior in young twins. Twin Research and Human Genetics, 10, 773–777.CrossRefGoogle Scholar
Hur, Y.-M. (2007c). Sex difference in heritability of BMI in South Korean adolescent twins. Obesity, 15, 2908–2911.CrossRefGoogle ScholarPubMed
Hur, Y.-M. (2008). Sex differences in genetic and environmental contributions to depression symptoms in South Korean adolescent and young adult twins. Twin Research and Human Genetics, 11, 306–313.CrossRefGoogle ScholarPubMed
Hur, Y.-M. (2009a). Genetic and environmental contributions to childhood temperament in South Korean twins. Twin Research and Human Genetics, 12, 549–554.CrossRefGoogle ScholarPubMed
Hur, Y.-M. (2009b). Genetic and environmental contributions to the covariations between obsessive-compulsive symptoms, neuroticism, and extraversion. Twin Research and Human Genetics, 12, 142–149.CrossRefGoogle ScholarPubMed
Hur, Y.-M. (2014). Increasing phenotypic and genetic variations in hyperactivity/inattention problems from age 3 to13 years: A cross-sectional twin study. Twin Research and Human Genetics, 17, 545–552.CrossRefGoogle Scholar
Hur, Y.-M. (2015). Genetic and environmental etiology of the relationship between childhood hyperactivity/inattention and conduct problems in a South Korean twin sample. Twin Research and Human Genetics, 18, 290–297.CrossRefGoogle Scholar
Hur, Y.-M., Chae, J.-H., Kim, J. J., Jeong, H.-U., Kim, J. W., Seo, S. Y., & Kim, K. S. (2012). Feeling of cold hands and feet is a highly heritable phenotype. Twin Research and Human Genetics, 15, 166–169.CrossRefGoogle ScholarPubMed
Hur, Y.-M., Cherny, S. S., & Sham, P. C. (2012). Heritability of hallucination in adolescent twins. Psychiatry Research, 199, 98–101.CrossRefGoogle ScholarPubMed
Hur, Y.-M., Choi, E.-J., Kim, J.-W., Jin, H.-J., & Lee, S. (2018). Heritability of Hwabyung symptoms in South Korean adolescent and young adult twins. Twin Research and Human Genetics, 21, 378–383.CrossRefGoogle ScholarPubMed
Hur, Y.-M., Hwang, S., & Chung, U.-S. (2015). Increasing relationship between negative emotionality and conduct problems during childhood: A cross-sectional behavioral genetic analysis. Twin Research and Human Genetics, 18, 785–792.CrossRefGoogle ScholarPubMed
Hur, Y.-M., & Jeong, H.-U. (2008). Sex differences in genetic and environmental influences on obsessive-compulsive symptoms in South Korean adolescent and young adult twins. Twin Research and Human Genetics, 11, 314–320.CrossRefGoogle ScholarPubMed
Hur, Y.-M., Jeong, H.-U., Chung, K. W., Shin, J. S., & Song, T. B. (2013). The South Korean Twin Registry: an update. Twin Research and Human Genetics, 16, 237–240.CrossRefGoogle ScholarPubMed
Hur, Y.-M., Jeong, H.-U, Schermer, J., & Rushton, J. P. (2011). Miserliness is heritable. Personality and Individual Differences, 51, 1052–1055.CrossRefGoogle Scholar
Hur, Y.-M., Jin, H.-J., & Lee, S. (2018). Etiologies of the relationships among body mass index and cold-heat patterns: A twin study. Twin Research and Human Genetics, 2, 233–238.CrossRefGoogle Scholar
Hur, Y.-M., Jin, H.-J., & Lee, S. (2019). Heritability of age at menarche in South Korean female twins. Twin Research and Human Genetics, 22, 183–186.CrossRefGoogle ScholarPubMed
Hur, Y.-M., Jin, H.-J., Lee, S., & Kim, J.-W. (2019). Shared genetic etiology of Hwabyung (anger syndrome) and somatization symptoms in South Korean adolescent and young adult twins. Twin Research and Human Genetics, 22, 114–119.CrossRefGoogle ScholarPubMed
Hur, Y.-M., Kaprio, J., Iacono, W. G., Boomsma, D. I., McGue, M., Silventoinen, K., & Mitchell, K. (2008). Genetic influences on the difference in variability of height, weight and body mass index between Caucasian and East Asian adolescent twins. International Journal of Obesity, 32, 1455–1467.CrossRefGoogle Scholar
Hur, Y.-M., & Kwon, J. S. (2005). Changes in twinning rates in South Korea: 1981-2002. Twin Research and Human Genetics, 8, 76–79.CrossRefGoogle ScholarPubMed
Hur, Y.-M., Lee, S., & Jin, H.-J. (2018). Genetic and environmental overlaps among Sasang Constitution Types: A multivariate twin Study. Twin Research and Human Genetics, 21, 518–526.CrossRefGoogle ScholarPubMed
Hur, Y.-M., Luciano, M., Martin, N. G., Boomsma, D. I., Iacono, W. G., McGue, M., & Han, J. Y. (2005). A comparison of twin birth weight data from Australia, the Netherlands, the United States, Japan, and South Korea: Are genetic and environmental variations in birth weight similar in Caucasians and East Asians? Twin Research and Human Genetics, 8, 638–648.CrossRefGoogle ScholarPubMed
Hur, Y.-M., & Rushton, J. P. (2007). Genetic and environmental contributions to prosocial behavior in 2- to 9- year-old South Korean twins. Biology Letters, 3, 664–666.CrossRefGoogle ScholarPubMed
Hur, Y.-M., & Shin, J. (2008). Effects of chorion type on genetic and environmental influences on height, weight, and body mass index in South Korean young twins. Twin Research and Human Genetics, 11, 63–69.CrossRefGoogle ScholarPubMed
Hur, Y.-M., Shin, J., Jeong, H-U., & Han, J. Y. (2006). The South Korean Twin Registry. Twin Research and Human Genetics, 9, 838–843.CrossRefGoogle ScholarPubMed
Hur, Y.-M., & Song, T.-B. (2009). A recent rise in twin birth rates and demographic changes in mothers of twins in South Korea: 2003–2007. Twin Research and Human Genetics, 12, 118–122.CrossRefGoogle ScholarPubMed
Hur, Y.-M., Yu, H., Jin, H.-J., & Lee, S. (2018). Heritability of cold and heat patterns: A twin study. Twin Research and Human Genetics, 21, 227–232.CrossRefGoogle ScholarPubMed
Koskenvuo, M., Kaprio, J., Rose, R. I., Kesaniemi, A., Sara, S., & Heikkila, K. (1988). Hostility as a risk factor for mortality and ischemic heart disease in men. Psychosomatic Medicine, 50, 330–340.CrossRefGoogle ScholarPubMed
Launay, G., & Slade, P. D. (1981). The measurement of hallucinatory predisposition in male and female prisoners. Personality and Individual Differences, 2, 221–234.CrossRefGoogle Scholar
Morey, L. C. (1991). Personality Assessment Inventory, professional manual. Lutz, FL: Personality Assessment Resources. Google Scholar
Olson, D. H., Portner, J., & Lavee, Y. (1985). FACES III. St. Paul, MN: Family Social Science, University of Minnesota.Google Scholar
Radloff, L. S. (1977). The CES-D scale: A self-report depression scale for research in the general population. Applied Psychological Measures, 1, 385–401.CrossRefGoogle Scholar
Raven, J. (2008). Standard progressive matrices-plus version and Mill Hill Vocabulary Scale. Manual. London: Pearson.Google Scholar
Rushton, J. P., Ann Bons, T., Ando, J., Hur, Y.-M., Irwing, P., Vernon, P. A., … Barbaranelli, C. (2009). A general factor of personality from multitrait-multimethod data and cross national twins. Twin Research and Human Genetics, 12, 356–365.CrossRefGoogle ScholarPubMed
Rushton, J. P., Ann Bons, T., & Hur, Y.-M. (2008). The genetics and evolution of the general factor personality. Journal of Research in Personality, 42, 1173–1183.CrossRefGoogle Scholar
Silventoinen, K., Jelenkovic, A., Yokoyama, Y., Sund, R., Sugawara, M., Tanaka, M., & Kaprio, J. (2019). The CODATwins Project: The current status and recent findings of COllaborative Project of Development of Anthropometrical Measures in Twins. Twin Research and Human Genetics. Advance online publication. doi: 10.1017/thg.2019.35.CrossRefGoogle Scholar
Veselka, V., Schermer, J. A., Just, C., Hur, Y-M., Rushton, J. P., Jeong, H-U., & Vernon, P. A. (2012). Emotion and behavior: A general factor of personality from the EAS Temperament Survey and the Strengths and Difficulties Questionnaire. Twin Research and Human Genetics, 15, 668–671.CrossRefGoogle ScholarPubMed
Figure 0

Table 1. Numbera of twins participated in studies of the South Korean Twin Registry by age group and zygosity