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An infant case of autosomal recessive polycystic kidney disease-associated dilated cardiomyopathy-like hypertensive cardiomyopathy diagnosed because of urinary tract infection

Published online by Cambridge University Press:  13 September 2024

Takato Akiba ,
Noboru Tanaka Open the ORCID record for Noboru Tanaka [Opens in a new window] ,
Mayu Nakagawa ,
Kotoko Matsui ,
Hideo Fukunaga Open the ORCID record for Hideo Fukunaga [Opens in a new window]  and
Toshiaki Shimizu
Takato Akiba
Affiliation:
Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan
Noboru Tanaka*
Affiliation:
Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan
Mayu Nakagawa
Affiliation:
Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan
Kotoko Matsui
Affiliation:
Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan
Hideo Fukunaga
Affiliation:
Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan
Toshiaki Shimizu
Affiliation:
Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan
*
Corresponding author: N. Tanaka; Email: [email protected]
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Abstract

We report a case of dilated cardiomyopathy-like hypertensive cardiomyopathy (HTN-CM) with polycystic kidney disease without family history when a 3-month-old boy developed bacteraemia secondary to a urinary tract infection. He was later confirmed as having autosomal recessive inheritance due to the proven PKHD1 gene mutation. The treatment consisted mainly of antihypertensive and anti-heart failure therapies and he was discharged on the 131st day. To prevent the development of heart failure in patients with HTN-CM due to autosomal recessive polycystic kidney disease (ARPKD), it is important to improve the fetal diagnosis rate of ARPKD, detect hypertension early, and strictly control the blood pressure after birth.

Keywords

Autosomal recessive polycystic kidney diseasedilated cardiomyopathyheart failurehypertensive cardiomyopathyinfant
Type
Brief Report
Information
Cardiology in the Young , Volume 34 , Issue 8 , August 2024 , pp. 1835 - 1837
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Copyright
© The Author(s), 2024. Published by Cambridge University Press

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References

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