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The role of microRNAs in the regulation of critical genes and signalling pathways that determine endometrial receptivity

Published online by Cambridge University Press:  18 September 2024

Yumei Wang Open the ORCID record for Yumei Wang [Opens in a new window] ,
Zhongxiang Ji ,
Ni Yao ,
Ximin Hu ,
Ran Zhou ,
Xingping Wang  and
Zhuoma Luoreng
Yumei Wang
Affiliation:
College of Animal Science and Technology, Ningxia University, Yin Chuan, NingXia, 750021, China
Zhongxiang Ji
Affiliation:
College of Animal Science and Technology, Ningxia University, Yin Chuan, NingXia, 750021, China
Ni Yao
Affiliation:
College of Animal Science and Technology, Ningxia University, Yin Chuan, NingXia, 750021, China
Ximin Hu
Affiliation:
College of Animal Science and Technology, Ningxia University, Yin Chuan, NingXia, 750021, China
Ran Zhou
Affiliation:
College of Animal Science and Technology, Ningxia University, Yin Chuan, NingXia, 750021, China
Xingping Wang*
Affiliation:
College of Animal Science and Technology, Ningxia University, Yin Chuan, NingXia, 750021, China
Zhuoma Luoreng*
Affiliation:
College of Animal Science and Technology, Ningxia University, Yin Chuan, NingXia, 750021, China
*
Corresponding authors: Xingping Wang; Email: [email protected]; Zhuoma Luoreng; Email: [email protected]
Corresponding authors: Xingping Wang; Email: [email protected]; Zhuoma Luoreng; Email: [email protected]
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Summary

Endometrial receptivity is the ability of the endometrium to accept embryos. Thus, endometrial receptivity dysfunction is an important factor leading to embryo implantation failure. A good endometrial receptivity provides a suitable environment for embryo implantation, improving the embryo implantation rate. The “implantation window” stage, or the receptive stage of the endometrium, is regulated by various hormones, genes, proteins and cytokines, among which microRNAs (miRNAs) and their target genes have a regulatory effect on endometrial receptivity. This review outlines the relationship between endometrial receptivity and pregnancy, the mRNAs and related signalling pathways that regulate endometrial receptivity, and the regulatory role of miRNA in endometrial receptivity, providing a deeper understanding of the regulatory mechanisms of miRNA on endometrial receptivity in humans and animals and reference for the endometrial receptivity-related research.

Keywords

miRNAendometrial receptivityembryo implantationendometrial epithelial cells
Type
Review Article
Information
Zygote , Volume 32 , Issue 4 , August 2024 , pp. 261 - 270
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Copyright
© The Author(s), 2024. Published by Cambridge University Press

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