Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-02T21:34:46.508Z Has data issue: false hasContentIssue false
  • English
  • Français

Clinical analysis of relapsing polychondritis with airway involvement

Published online by Cambridge University Press:  02 February 2022

S-Y Zhai ,
R-Y Guo ,
C Zhang ,
C-M Zhang ,
H-Y Yin ,
B-Q Wang  and
S-X Wen Open the ORCID record for S-X Wen [Opens in a new window]
S-Y Zhai
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, First Clinical College of Shanxi Medical University, Taiyuan, Shanxi, China
R-Y Guo
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, First Clinical College of Shanxi Medical University, Taiyuan, Shanxi, China
C Zhang
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
C-M Zhang
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China Shanxi Key Laboratory of Otolaryngology Head and Neck Cancer, Taiyuan, Shanxi, China
H-Y Yin
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Kunshan Maternal and Child Health Hospital, Kunshan, Jiangsu, China
B-Q Wang
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China Shanxi Key Laboratory of Otolaryngology Head and Neck Cancer, Taiyuan, Shanxi, China
S-X Wen*
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, Shanxi Bethune Hospital (Third Hospital of Shanxi Medical University), Taiyuan, Shanxi, China
*
Author for correspondence: Dr Shuxin Wen, Department of Otorhinolaryngology Head and Neck Surgery, Shanxi Bethune Hospital (aka Third Hospital of Shanxi Medical University), No. 99 Longcheng Street, Taiyuan 030000, Shanxi, China E-mail: [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Objective

To identify the clinical characteristics, treatment, and prognosis of relapsing polychondritis patients with airway involvement.

Methods

Twenty-eight patients with relapsing polychondritis, hospitalised in the First Hospital of Shanxi Medical University between April 2011 and April 2021, were retrospectively analysed.

Results

Fifty per cent of relapsing polychondritis patients with airway involvement had a lower risk of ear and ocular involvement. Relapsing polychondritis patients with airway involvement had a longer time-to-diagnosis (p < 0.001), a poorer outcome following glucocorticoid combined with immunosuppressant treatment (p = 0.004), and a higher recurrence rate than those without airway involvement (p = 0.004). The rates of positive findings on chest computed tomography and bronchoscopy in relapsing polychondritis patients with airway involvement were 88.9 per cent and 85.7 per cent, respectively. Laryngoscopy analysis showed that 66.7 per cent of relapsing polychondritis patients had varying degrees of mucosal lesions.

Conclusion

For relapsing polychondritis patients with airway involvement, drug treatment should be combined with local airway management.

Keywords

Polychondritis, RelapsingLarynxTracheaDiagnosisTreatment
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 137 , Issue 1 , January 2023 , pp. 96 - 100
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

Introduction

As a rare multi-systemic autoimmune disease,Reference Chen and Wang1 relapsing polychondritis is characterised by recurrent inflammation and progressive damage to cartilage at the lesion site. Relapsing polychondritis mainly afflicts systemic cartilage and proteoglycan-rich tissues. There are high rates of misdiagnosis and missed diagnosis in relapsing polychondritis patients with airway involvement. Irreversible damage to the tracheal cartilage can result in tracheal collapse and treatment failure, which complicates airway treatment, increases the financial burden on the patient, and may lead to death.Reference Hazra, Dregan, Charlton, Gulliford and D'Cruz2

Tremendous advancements have been accomplished in the diagnosis and treatment of relapsing polychondritis. However, a comprehensive clinical comparison has not been performed on relapsing polychondritis patients with or without airway involvement. This research compared the clinical characteristics, diagnosis and treatment of relapsing polychondritis patients with and without airway involvement. The findings obtained in the current study form a crucial clinical basis for the diagnosis and treatment of relapsing polychondritis.

Materials and methods

Patients

This study comprised 28 in-patients (16 males and 12 females) diagnosed with relapsing polychondritis at the First Hospital of Shanxi Medical University between April 2011 and April 2021. The mean age of onset of relapsing polychondritis was 45 ± 15 years, ranging from 18 to 68 years. Further examination showed that 14 patients presented with airway involvement.

Diagnostic criteria

The diagnostic criteria for relapsing polychondritis by Damiani and LevineReference Damiani and Levine3 are as follows: (1) patients meeting three or more of the McAdam et al.Reference McAdam, O'Hanlan, Bluestone and Pearson4 criteria (i.e. recurrent bilateral auricular chondritis; non-erosive inflammatory polyarthritis; nasal chondritis; inflammation of ocular structures; chondritis of the respiratory tract; and cochlear and/or vestibular damage); (2) patients meeting one of six of McAdam et al. criteria, with a positive histological confirmation; and (3) patients matching two of six of McAdam et al. criteria, and who respond to corticosteroids or dapsone (satisfying any of these criteria). Patients who met one or more of the preceding criteria were classified as relapsing polychondritis patients.Reference Longo, Greco, Rea, Lo Vasco, De Virgilio and De Vincentiis5

Relapsing polychondritis with airway involvement was defined as follows: (1) patients meeting the diagnostic criteria of Damiani and Levine; (2) patients with airway involvement symptoms at the time of disease onset or progression, and patients without relevant symptoms but with laryngeal or tracheobronchial cartilage involvement as revealed by computed tomography (CT) examination; and (3) patients without laryngeal tumours, tracheobronchial tumours, bronchial asthma, laryngeal amyloidosis, laryngeal or tracheobronchial tuberculosis, or granulomatosis with polyangiitis.

Treatment

Patients in both groups (with or without airway involvement) received glucocorticoid (30–40 mg/day) in combination with immunosuppressive drugs (methotrexate, cyclosporine or cyclophosphamide). When the aforesaid treatment options failed, biological medication or surgical treatment was utilised as a supplement.

Statistical analysis

Statistical analysis was performed using SPSS® software version 21.0. Categorical data were expressed as percentages, and were compared using Fisher's exact test or the rank-sum test. Continuous data conforming to normal distribution were expressed as mean ± standard deviation values, and analysed using the independent sample t-test. Non-normally distributed data were presented as interquartile ranges and compared using the non-parametric rank-sum test. All statistical tests were two-sided, and the significance level was set at a p-value of less than 0.05.

Results

Clinical characteristics

Table 1 displays the information on patients’ age and gender. The findings depicted no statistically significant differences between the two groups in terms of demographic characteristics.

Table 1. Comparisons of clinical characteristics between relapsing polychondritis patients with or without airway involvement

RP = relapsing polychondritis; NS = not significant

Clinical examination demonstrated that 12 of the 28 relapsing polychondritis patients presented with ear involvement at the time of disease onset. Additionally, 15 relapsing polychondritis patients developed ear involvement during disease progression. Airway involvement occurred in 10 relapsing polychondritis patients, and airway involvement symptoms developed in 14 relapsing polychondritis patients during disease progression. There were 2 relapsing polychondritis patients with ocular inflammation at the time of disease onset, and 11 relapsing polychondritis patients developing ocular inflammation as the disease progressed. Nasal cartilage inflammation was observed in one relapsing polychondritis patient, while collapsed or swollen nasal cartilage was noted in six relapsing polychondritis patients. Our data suggested two cases of airway involvement including ear involvement, two cases with eye involvement, and five with nasal involvement.

Comparisons of treatment and prognosis

The symptoms of 13 relapsing polychondritis patients (8 patients with the airway intact and 5 patients with airway involvement) were managed with glucocorticoids combined with immunosuppressants. The results revealed that patients in the two groups underwent significantly different treatment modalities. Additionally, relapsing polychondritis patients with airway involvement had a higher re-hospitalisation rate because of recurrence than those without airway involvement (Table 1).

Discussion

Relapsing polychondritis is a rare autoimmune disease that influences both males and females,Reference Smylie, Malhotra and Brassard6 but has a higher prevalence in middle-aged individuals. Our research included 16 males and 12 females, with age of disease onset ranging from 18 to 68 years. No obvious differences were observed between patients with and without airway involvement regarding gender and age.

The annual incidence of relapsing polychondritis ranges from 0.71 to 3.5 per million people,Reference McAdam, O'Hanlan, Bluestone and Pearson4 and 18–26 per cent of relapsing polychondritis patients present with respiratory involvement.Reference Eng and Sabanathan7 Approximately half of relapsing polychondritis patients experience different degrees of airway involvement during disease progression.Reference de Montmollin, Dusser, Lorut, Dion, Costedoat-Chalumeau and Mouthon8 A retrospective analysis of 142 relapsing polychondritis patients in France found that 43 per cent of the patients had laryngeal involvement and 22 per cent had tracheal involvement.Reference Dion, Costedoat-Chalumeau, Sène, Cohen-Bittan, Leroux and Dion9 Furthermore, a retrospective analysis of 239 patients found that airway involvement occurred in 50 per cent of relapsing polychondritis patients.Reference Shimizu, Yamano, Kawahata and Suzuki10 Two large-sample studies conducted in China reported that approximately 69–81.7 per cent of relapsing polychondritis patients had airway involvement.Reference Zhang, Wang, Yan, Yang, Wu and Wu11,Reference Lin, Yang, Zhang, Lv, Jin and Gu12 Wang et al. performed a prospective study, and reported that approximately 81.5 per cent of relapsing polychondritis patients had airway involvement.Reference Wang, Chen, Cui, Gao and Wang13

In the current study, a retrospective case comparative analysis was conducted, and the findings revealed that patients with airway involvement accounted for 50 per cent of all relapsing polychondritis patients. Of note, the clinical misdiagnosis rate for relapsing polychondritis patients with airway involvement was high, at 85.7 per cent, suggesting a high incidence of relapsing polychondritis patients with airway involvement. However, laboratory and pathological auxiliary examinations are ineffective for diagnosis, as atypical clinical symptoms contribute to a high rate of misdiagnosis.

Clinical typing of relapsing polychondritis is critical to improve diagnostic rates. A previous study categorised relapsing polychondritis into three types based on the affected sites: ‘R’ type, characterised by airway involvement; ‘A’ type, characterised by ear involvement; and ‘O’ type, characterised by airway and ear involvement. These types were analysed, and it was discovered that there were conspicuous differences in the incidence, clinical diagnosis and treatment of patients with different types of relapsing polychondritis.Reference Shimizu, Yamano, Kawahata and Suzuki10 Additionally, a French study revealed that although airway involvement is the major cause of death in relapsing polychondritis patients, airway involvement is not highly correlated with heart involvement.Reference Dion, Costedoat-Chalumeau, Sène, Cohen-Bittan, Leroux and Dion9 Research conducted in China classified relapsing polychondritis into four types based on the affected organs, as follows: ‘A’ type, characterised by airway involvement; ‘B’ type, characterised by ear involvement; ‘C’ type, characterised by overlapping involvements; and ‘D’ type, in which the airway and ear are unaffected. The results revealed noticeable differences in the clinical diagnosis and prognosis among the types. Patients with subtype A relapsing polychondritis had a greater risk of nasal cartilage involvement, and those with subtype B disease had a higher risk of eye involvement and a better prognosis than patients with the other subtypes.Reference Zhang, Yun, Wu, He, Guo and Han14

In this study, relapsing polychondritis patients were assigned to two groups based on the presence or absence of airway involvement. Patients with airway involvement were less likely to develop ear and eye involvement than those without airway involvement. Additionally, airway involvement was difficult to diagnose, with higher rates of misdiagnosis and missed diagnosis in this group, triggering a protracted disease course, increased re-hospitalisation rates and a poor prognosis (Tables 1 and 2).

Table 2. Comparison of time-to-diagnosis between relapsing polychondritis patients with or without airway involvement

RP = relapsing polychondritis; SD = standard deviation

Airway involvement is the main risk factor for death in relapsing polychondritis patients.Reference Ernst, Rafeq, Boiselle, Sung, Reddy and Michaud15 Early and timely diagnosis and treatment can substantially improve the prognosis of relapsing polychondritis patients with airway involvement.Reference Wang, Chen, Cui, Gao and Wang13 However, the existing diagnostic criteria are mainly based on the clinical characteristics of patients, and are ineffective for the early diagnosis of relapsing polychondritis. Prior reports revealed that additional investigations, such as CT and endoscopy of the neck and chest, can be applied for the early diagnosis and differential diagnosis of relapsing polychondritis.Reference Dubey, Gelder, Pink, Ali, Taylor and Shakespeare16–Reference Thaiss, Nikolaou, Spengler, Spira, Xenitidis and Henes18 In our study, the rate of positive chest CT examination findings, namely varying degrees of airway thickening, stenosis and calcification, was 88.9 per cent in airway-affected patients. The predominant symptom was thickening of the main bronchial wall, which is concordant with the findings of Wang et al.Reference Wang, Chen, Cui, Gao and Wang13 Bronchoscopy exhibited findings that were positive for airway involvement in 85.7 per cent of patients. The findings demonstrated varying degrees of tracheal mucosal thickening, stenosis and oedema in relapsing polychondritis patients. Multiple mucosal lesions appeared in 66.7 per cent of patients, as determined by laryngoscopy analysis. In patients with laryngeal involvement, the neck CT results were concurrent with the laryngoscopy results.

Prior studies have shown that 18F-fluoro-2-deoxyglucose positron emission tomography (FDG-PET)/CT images exhibited the characteristic features of relapsing polychondritis.Reference Kubota, Yamashita and Mimori19,Reference Kamada, Takanami, Toyama, Saito and Takase20 Chen et al. conducted a review of 28 relapsing polychondritis patients with airway involvement, all of whom underwent PET/CT examination.Reference Chen, Pan, Guan, Yang, Liu and Chen21 Twenty-four PET/CT scans of the tracheal and bronchial trachea revealed augmented density, tube wall oedema, thickening and calcification, and limited stenosis. Furthermore, four patients had increased density and tube wall thickening, and oedema in laryngeal cartilage. Intriguingly, PET/CT assumes a pivotal role in guiding biopsy, because of the high metabolic rate at the affected site. Biopsy performed at sites with hypermetabolic activity according to PET/CT was associated with positive results in 93.3 per cent of cases, illustrating that this imaging is effective for the diagnosis of relapsing polychondritis.Reference Lei, Zeng, Zeng, Zhang, Zhu and Jiang22 In our study, one patient was diagnosed with relapsing polychondritis following PET-CT examination. However, the role of PET-CT in the diagnosis and prognosis of relapsing polychondritis should be further explored.

The findings showed that glucocorticoids and immunosuppressants were ineffective in relapsing polychondritis patients with airway involvement, emphasising that early pharmacological management is necessary to prevent relapsing polychondritis progression. Patients with dyspnoea should have their treatment plans adjusted to their condition, and effective surgical intervention should be implemented when appropriate.Reference Guo, Zhao, Xing, Liang, Yang and Zhao23

At present, tracheostomy and endotracheal stent implantation are the only surgical options for the short-term relief of dyspnoea. Oryoji et al.Reference Oryoji, Ono, Himeji, Yoshihiro, Kai and Matsuda24 successfully resuscitated a 73-year-old man who had suffered acute respiratory failure due to relapsing polychondritis with airway involvement, through metal stent implantation and tracheostomy. In the present study, five patients underwent a tracheostomy in addition to receiving glucocorticoid and immunosuppressants; effective airway management was achieved in four of these patients.

Stent placement is prone to complications such as stent fracture, pulmonary artery or airway erosion, bleeding, or granulation tissue ingrowth.Reference Wu, Zhang, Zhang, Huang and Li25 In light of this, and because complications including respiratory infection and airway obstruction usually occur four to six weeks following surgery, some scholars suggest an initial review period of two to four weeks, followed by review every three months.Reference Wang26 In a study by Guo et al.,Reference Guo, Zhao, Xing, Liang, Yang and Zhao23 a patient implanted with membrane-covered stents for half a year developed extensive granulation tissue growth and mucosal destruction, as observed at follow up, necessitating removal of the stents. In this study, one patient with central airway involvement suffered granulation tissue hyperplasia at the stent – a post-stenting complication; this patient eventually died after developing pulmonary infection and dyspnoea.

For long-term treatment, the surgical treatment regimens include: tracheobronchial external fixation, laryngeal tracheal reconstruction, tracheal sleeve resection, and balloon dilatation with adjustable pressure and security performance.Reference Oryoji, Ono, Himeji, Yoshihiro, Kai and Matsuda24,Reference Li, He and Zhang27,Reference Xie, Shah, Shah and Sandhu28 Tracheobronchial external fixation, in which the collapsed trachea is sutured and suspended over autologous tissues or grafts to open the airway, is suitable for patients with extensive airway softening and collapse. Laryngeal tracheal reconstruction is indicated for patients with limited stenosis of the trachea or subglottis. It utilises a sternocleidomastoid muscle flap or costal cartilage to broaden the laryngeal tracheal reconstruction. Xie et al.Reference Xie, Shah, Shah and Sandhu28 reported a successful tracheal restoration using thymus lingual muscle, in a patient with laryngeal stenosis induced by relapsing polychondritis. Tracheal sleeve resection, which is suitable for limited airway stenosis, requires long-term drug treatment and a T-type tube following surgery. Balloon dilatation with adjustable pressure and security performance is suitable for relapsing polychondritis induced laryngeal and tracheal stenosis.

One retrospective study enrolled 11 patients with different degrees of airway stenosis caused by relapsing polychondritis, in which: 9 patients underwent laryngotracheal reconstruction surgery with a sternohyoid myocutaneous flap or costal cartilage to widen laryngeal tracheal reconstruction, 1 patient underwent long-term T-tube placement, and 1 patient underwent routine balloon dilatation. All patients had complete recovery of respiratory and swallowing functions after two to seven years.Reference Guo, Zhao, Xing, Liang, Yang and Zhao23

In addition to the surgery itself, we should calm patients’ emotions prior to treatment, administer anaesthesia, and adequately absorb and discharge sputum, all of which should be supported by hormone therapy pre- and post-operatively.

Biological medication has revolutionised the management of refractory relapsing polychondritis. For instance, tumour necrosis factor-α and interleukin-6 receptor antagonists are effective in the treatment of relapsing polychondritis cases.Reference Lekpa and Chevalier29 However, randomised double-blind experiments with large samples are required to verify their effectiveness. In the current study, two patients received adalimumab injections; the results indicated that this treatment was effective in one patient. Bronchial involvement causes diffuse airway stenosis in patients, with the majority of these lesions occurring in the thoracic segment, for which nasal positive pressure ventilation is recommended.Reference Yu and Joosten30 Patients who require urgent surgical treatment should be counselled before treatment and administered adequate anaesthesia. Additionally, complete sputum suction and hormone treatment may be employed as adjunctive therapies.

  • • In relapsing polychondritis with airway involvement, misdiagnosis and missed diagnosis rates rise, resulting in longer time-to-diagnosis, more re-admissions and worse outcomes

  • • Despite diagnosis and treatment advances, there is no specific examination, making clinical diagnosis problematic, and medication remains the mainstay of therapeutic care

  • • This study evaluated clinical features, therapeutic choices and prognosis of relapsing polychondritis patients with airway involvement

  • • Computed tomography and endoscopy are excellent clinical diagnostic tools for relapsing polychondritis patients with airway involvement

  • • To enhance prognosis, relapsing polychondritis patients should receive tailored therapeutic treatments; drug therapy should be used in conjunction with local airway control

Conclusion

The findings demonstrated that 50 per cent of relapsing polychondritis patients presented with airway involvement as the disease progressed. However, owing to the lack of specific examination methods and poor awareness of the disease, the clinical misdiagnosis rate was high (85.7 per cent). Clinical diagnostic and treatment outcomes for relapsing polychondritis patients were markedly different between the airway-affected and airway-unaffected subgroups. These findings suggest that relapsing polychondritis patients should undergo an individualised therapeutic regimen and be reviewed regularly to improve their prognosis.

Acknowledgement

We would like to acknowledge the reviewers for their helpful comments on this paper.

Competing interests

None declared

Footnotes

Dr S-X Wen takes responsibility for the integrity of the content of the paper

References

Chen, N, Wang, Z. Progress in the pathology and pathogenesis of relapsing polychondritis. Chinese Journal of Rheumatology 2019;3:207–11Google Scholar
Hazra, N, Dregan, A, Charlton, J, Gulliford, MC, D'Cruz, DP. Incidence and mortality of relapsing polychondritis in the UK: a population-based cohort study. Rheumatology (Oxford) 2015;54:2181–7Google Scholar
Damiani, JM, Levine, HL. Relapsing polychondritis--report of ten cases. Laryngoscope 1979;89:929–46Google ScholarPubMed
McAdam, LP, O'Hanlan, MA, Bluestone, R, Pearson, CM. Relapsing polychondritis: prospective study of 23 patients and a review of the literature. Medicine (Baltimore) 1976;55:193–215CrossRefGoogle Scholar
Longo, L, Greco, A, Rea, A, Lo Vasco, VR, De Virgilio, A, De Vincentiis, M. Relapsing polychondritis: a clinical update. Autoimmun Rev 2016;15:539–43CrossRefGoogle ScholarPubMed
Smylie, A, Malhotra, N, Brassard, A. Relapsing polychondritis: a review and guide for the dermatologist. Am J Clin Dermatol 2017;18:77–86CrossRefGoogle ScholarPubMed
Eng, J, Sabanathan, S. Airway complications in relapsing polychondritis. Ann Thorac Surg 1991;51:686–92CrossRefGoogle ScholarPubMed
de Montmollin, N, Dusser, D, Lorut, C, Dion, J, Costedoat-Chalumeau, N, Mouthon, L et al. Tracheobronchial involvement of relapsing polychondritis. Autoimmun Rev 2019;18:102353CrossRefGoogle ScholarPubMed
Dion, J, Costedoat-Chalumeau, N, Sène, D, Cohen-Bittan, J, Leroux, G, Dion, C et al. Relapsing polychondritis can be characterized by three different clinical phenotypes: analysis of a recent series of 142 patients. Arthritis Rheumatol 2016;68:2992–3001CrossRefGoogle ScholarPubMed
Shimizu, J, Yamano, Y, Kawahata, K, Suzuki, N. Relapsing polychondritis patients were divided into three subgroups: patients with respiratory involvement (R subgroup), patients with auricular involvement (A subgroup), and overlapping patients with both involvements (O subgroup), and each group had distinctive clinical characteristics. Medicine (Baltimore) 2018;97:e12837CrossRefGoogle ScholarPubMed
Zhang, H, Wang, L, Yan, L, Yang, J, Wu, C, Wu, D et al. Clinical characteristics of patients with recurrent polyrickets [in Chinese]. National Medical Journal of China 2015;95:2375–8Google Scholar
Lin, DF, Yang, WQ, Zhang, PP, Lv, Q, Jin, O, Gu, JR. Clinical and prognostic characteristics of 158 cases of relapsing polychondritis in China and review of the literature. Rheumatol Int 2016;36:1003–9CrossRefGoogle ScholarPubMed
Wang, Z, Chen, N, Cui, L, Gao, Y, Wang, Y. Insidious airway involvement in patients with relapsing polychondritis [in Chinese]. Chinese Journal of Rheumatology 2018;22:452–8Google Scholar
Zhang, L, Yun, S, Wu, TG, He, Y, Guo, J, Han, L et al. Clinical patterns and the evolution of relapsing polychondritis based on organ involvement: a Chinese retrospective cohort study. Orphanet J Rare Dis 2021;16:225CrossRefGoogle ScholarPubMed
Ernst, A, Rafeq, S, Boiselle, P, Sung, A, Reddy, C, Michaud, G et al. Relapsing polychondritis and airway involvement. Chest 2009;135:1024–30CrossRefGoogle ScholarPubMed
Dubey, S, Gelder, C, Pink, G, Ali, A, Taylor, C, Shakespeare, J et al. Respiratory subtype of relapsing polychondritis frequently presents as difficult asthma: a descriptive study of respiratory involvement in relapsing polychondritis with 13 patients from a single UK centre. ERJ Open Res 2021;7:00170–2020CrossRefGoogle ScholarPubMed
Shi, X, Tong, S, Su, J, Huang, H, Zhang, F, Tang, F et al. Characteristics of airway involvement in relapsing polychondritis [in Chinese]. National Medical Journal of China 2006;86:1048–51Google ScholarPubMed
Thaiss, WM, Nikolaou, K, Spengler, W, Spira, D, Xenitidis, T, Henes, J et al. Imaging diagnosis in relapsing polychondritis and correlation with clinical and serological data. Skeletal Radiol 2016;45:339–46CrossRefGoogle ScholarPubMed
Kubota, K, Yamashita, H, Mimori, A. Clinical value of FDG-PET/CT for the evaluation of rheumatic diseases: rheumatoid arthritis, polymyalgia rheumatica, and relapsing polychondritis. Semin Nucl Med 2017;47:408–24CrossRefGoogle ScholarPubMed
Kamada, H, Takanami, K, Toyama, Y, Saito, M, Takase, K. 18F-FDG PET/CT imaging of vasculitis complicated with relapsing polychondritis. Clin Nucl Med 2020;45:e327–8CrossRefGoogle ScholarPubMed
Chen, Y, Pan, X, Guan, Y, Yang, X, Liu, H, Chen, P et al. 18F-FDG PET/CT in diagnosis of relapsing polychondritis [in Chinese]. Chinese Medical Image Technology 2019;35:138–42Google Scholar
Lei, W, Zeng, H, Zeng, DX, Zhang, B, Zhu, YH, Jiang, JH et al. (18)F-FDG PET-CT: a powerful tool for the diagnosis and treatment of relapsing polychondritis. Br J Radiol 2016;89:20150695CrossRefGoogle ScholarPubMed
Guo, Z, Zhao, D, Xing, Y, Liang, L, Yang, J, Zhao, Q et al. Diagnosis and treatment of laryngotracheal stenosis induced by relapsing polychondritis [in Chinese]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020;34:524–7Google ScholarPubMed
Oryoji, D, Ono, N, Himeji, D, Yoshihiro, K, Kai, Y, Matsuda, M et al. Sudden respiratory failure due to tracheobronchomalacia by relapsing polychondritis, successfully rescued by multiple metallic stenting and tracheostomy. Intern Med 2017;56:3369–72CrossRefGoogle ScholarPubMed
Wu, X, Zhang, X, Zhang, W, Huang, H, Li, Q. Long-term outcome of metallic stenting for central airway involvement in relapsing polychondritis. Ann Thorac Surg 2019;108:897–904CrossRefGoogle ScholarPubMed
Wang, H-W. Strict control of tracheal stent indications, timely treatment of complications. Chinese Journal of Tuberculosis and Respiratory Diseases 2014;37:221–2Google Scholar
Li, W-Y, He, L, Zhang, L-S. Laryngotracheobronchial involvement in relapsing polychondritis [in Chinese]. Zhonghua Er Bi Yan Hou Ke Za Zhi 1999;34:314–16Google ScholarPubMed
Xie, C, Shah, N, Shah, PL, Sandhu, G. Laryngotracheal reconstruction for relapsing polychondritis: case report and review of the literature. J Laryngol Otol 2013;127:932–5CrossRefGoogle ScholarPubMed
Lekpa, FK, Chevalier, X. Refractory relapsing polychondritis: challenges and solutions. Open Access Rheumatol 2018;10:1–11CrossRefGoogle ScholarPubMed
Yu, C, Joosten, SA. Relapsing polychondritis with large airway involvement. Respirol Case Rep 2020;8:e00501CrossRefGoogle ScholarPubMed
Figure 0

Table 1. Comparisons of clinical characteristics between relapsing polychondritis patients with or without airway involvement

Figure 1

Table 2. Comparison of time-to-diagnosis between relapsing polychondritis patients with or without airway involvement