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Association of dietary manganese intake and the IL1R1 rs3917225 polymorphism with thyroid cancer risk: a prospective cohort study in Korea

Published online by Cambridge University Press:  13 November 2024

Tao Thi Tran ,
Ha Thi Mien Nguyen ,
Madhawa Gunathilake ,
Jeonghee Lee  and
Jeongseon Kim Open the ORCID record for Jeongseon Kim [Opens in a new window]
Tao Thi Tran
Affiliation:
Department of Cancer AI and Digital Health, Graduate School of Cancer Science and Policy, Goyang-si, Republic of Korea Faculty of Public Health, University of Medicine and Pharmacy, Hue University, Hue city, Vietnam
Ha Thi Mien Nguyen
Affiliation:
Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, Goyang-si, Republic of Korea
Madhawa Gunathilake
Affiliation:
Department of Cancer AI and Digital Health, Graduate School of Cancer Science and Policy, Goyang-si, Republic of Korea
Jeonghee Lee
Affiliation:
Department of Cancer AI and Digital Health, Graduate School of Cancer Science and Policy, Goyang-si, Republic of Korea
Jeongseon Kim*
Affiliation:
Department of Cancer AI and Digital Health, Graduate School of Cancer Science and Policy, Goyang-si, Republic of Korea
*
*Corresponding author: Dr Jeongseon Kim, email [email protected]
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Abstract

Dietary Mn intake may have a beneficial effect in reducing cancer risk; however, its association with thyroid cancer (TC) risk remains inadequately understood. Additionally, Mn was associated with inflammation markers. Thus, we examined whether dietary Mn intake emerges a protective role against TC and whether this preventative effect has an interaction with IL1 receptor type 1 (IL1R1) rs3917225. The prospective study was designed at National Cancer Center in Korea between October 2007 and December 2020 including 17 754 participants. We identified TC cases by following participants until December 2020. Mn intake was collected using a semiquantitative food frequency questionnaire (SQFFQ). Genotyping was performed to determine IL1R1 rs3917225. The hazard ratios (HR) and 95 % confidence interval (CI) were calculated with a Cox proportional hazards model. We ascertained 108 incident TC cases throughout follow-up duration. Dietary Mn intake was found to be inversely associated with TC risk (HR (95 % CI)=0·64 (0·44, 0·95)). However, IL1R1 rs3917225 seemed to modify this association; the protective effect was limited to G-allele carriers (HR = 0·30 (0·11, 0·86), P interaction=0·028). A higher dietary Mn was suggested to be a protective factor against TC. Additionally, we drew a potential biological interaction between Mn intake and IL1R1 rs3917225 with a greater effect among individuals with a minor allele. This implies that when considering the cancer-preventive role of Mn, it is important to account for the influence of inflammatory gene participation.

Keywords

ManganeseIL1R1 rs3917225Thyroid cancerProspective cohort
Type
Research Article
Information
British Journal of Nutrition , Volume 132 , Issue 12 , 28 December 2024 , pp. 1584 - 1592
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Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society

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Footnotes

†

These authors have contributed equally to this work and share first authorship.

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