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Social cognition in adults with neurofibromatosis type 1

Published online by Cambridge University Press:  18 October 2024

Julie Remaud Open the ORCID record for Julie Remaud [Opens in a new window] ,
Jérémy Besnard ,
Sébastien Barbarot  and
Arnaud Roy
Julie Remaud*
Affiliation:
Univ Angers, Nantes Université, LPPL, SFR CONFLUENCES, Angers, France
Jérémy Besnard
Affiliation:
Univ Angers, Nantes Université, LPPL, SFR CONFLUENCES, Angers, France
Sébastien Barbarot
Affiliation:
Nantes Neurofibromatosis Expert Center, Nantes University Hospital, Nantes, France
Arnaud Roy
Affiliation:
Univ Angers, Nantes Université, LPPL, SFR CONFLUENCES, Angers, France Reference Center for Learning Disabilities, Nantes University Hospital, Nantes, France
*
Corresponding author: Julie Remaud; Email: [email protected]
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Abstract

Objective:

Adult patients with the genetic disease neurofibromatosis type 1 (NF1) frequently report social difficulties. To date, however, only two studies have explored whether these difficulties are caused by social cognition deficits, and these yielded contradictory data. The aim of the present study was to exhaustively assess social cognition abilities (emotion, theory of mind, moral reasoning, and social information processing) in adults with NF1, compared with a control group, and to explore links between social cognition and disease characteristics (mode of inheritance, severity, and visibility).

Method:

We administered a social cognition battery to 20 adults with NF1 (mean age = 26.5 years, SD = 7.4) and 20 healthy adults matched for sociodemographic variables.

Results:

Patients scored significantly lower than controls on emotion, theory of mind, moral reasoning, and social information processing tasks. No effects of disease characteristics were found.

Conclusions:

These results appear to confirm that adults with NF1 have a social cognition weaknesses that could explain, at least in part, their social difficulties, although social abilities are not all impaired to the same extent. Regarding the impact of the disease characteristics, the patient sample seemed slightly insufficient for the power analyses performed. Thus, this exploratory study should form the basis of further research, with the objective of replicating these results with larger and more appropriately matched samples.

Keywords

Social cognitionemotionstheory of mindmoral reasoningneurofibromatosis type 1disease characteristics
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 30 , Issue 9 , November 2024 , pp. 875 - 883
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of International Neuropsychological Society

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