INTRODUCTION
Population mobility has been identified as a key driver of the HIV epidemic [Reference Deane, Parkhurst and Johnston1], by both linking geographically separate epidemics [Reference Deane, Parkhurst and Johnston1] and intensifying transmission through the introduction of risk behaviours that increase vulnerability to HIV infection [Reference Deane, Parkhurst and Johnston1–Reference Saigí, Espelt and Folch3]. Moreover, this can be exacerbated by other factors such as family fragmentation, adaptation to the host culture, language barriers, poor living conditions, job insecurity, unequal access to preventive, diagnostic and treatment services in host communities [4–6].
In 2014, migrants constituted a considerable proportion (37%) of new HIV diagnoses in the EU/EEA [7] and the evidence increasingly indicates that a high proportion of these acquired HIV after migration [Reference Rice, Elford and Yin8, Reference Fakoya, Álvarez-del Arco and Woode-Owusu9]. Although attention in recent years has focused on migrants from high prevalence countries with generalised epidemics, there is evidence that specific migrant groups from other regions with more concentrated epidemics, such as men who have sex with men (MSM) from Latin America, are also highly vulnerable to HIV [4, Reference Hernando, Alvárez-Del Arco and Alejos10–Reference Ferrer, Loureiro and Meulbroek12]. Late presentation for HIV diagnosis among migrants is also a key concern. A higher proportion of HIV-positive male and female migrants from low- and middle-income regions present late for HIV diagnosis as compared with native-born populations [Reference Hernando, Alvárez-Del Arco and Alejos10]. Migration has also been associated with slower progression through the HIV care cascade; with increased risk of non-adherence to antiretroviral therapy (ART), loss to follow-up, deterioration in CD4 count, HIV-related death and development of drug resistance [Reference Tanser, Bärnighausen and Vandormael13].
Because of their increased vulnerability, migrants have been recognised as a priority group when designing programmes for HIV prevention and care in Europe [Reference Hernando, Alvárez-Del Arco and Alejos10, 14]. To better understand the metrics and determinants that can improve the effectiveness of such programmes, this study aims to describe differences between migrants and the Spanish-born population at diagnosis and as they progress through the HIV care in Catalonia, Spain.
MATERIALS AND METHODS
We undertook descriptive and comparative data analysis to identify differences between migrants and Spanish-born people along the HIV care cascade, using multiple sources of information from the integrated Catalan sexually transmitted infection (STI)/HIV Surveillance System (SIVES). Determinants of sexual risk and HIV test-seeking behaviours, HIV trends and clinical and epidemiological characteristics were all assessed. Migrants were defined as individuals born in a country other than Spain and aged 18 or over. Region of origin was determined by the country of birth and was classified as follows: Western Europe and North America, Eastern Europe, sub-Saharan Africa (SSA), North Africa, and Latin America and the Caribbean. The Spanish-born population was defined as people who reported their place of birth Spain. HIV and AIDS cases were defined according to the criteria of the European Centre for AIDS/HIV Epidemiological Surveillance [15]. Retained in care was defined as the proportion enrolled in the PISCIS cohort during the study period and who had at least one visit in the year following after their enrolment. Late presentation was defined as a CD4 count of <350 cells/μl or AIDS, and advanced HIV infection as a CD4 cell count below 200 cells/ml or AIDS at the time of HIV diagnosis, in line with the European Late Presenter Consensus Working Group [Reference Antinori, Coenen and Costagiola16]. Viral load suppression was defined as the proportion of patients on ART and who had <50 copies/ml on the last measurement of the year. Loss to follow-up was defined as a patient who had been followed up at the HIV clinic, who had not had contact with the health facility for 1 year or more since their last recorded expected date of return or if there was one year or more between the expected date of return and the next clinic visit.
Sources of data
A full description of the information systems that form part of SIVES is available elsewhere [17]. This paper is structured in accordance with the conceptual depiction of the HIV cascade of services as described in WHO's Consolidated strategic information guidelines for HIV [18].
People at risk and reached by prevention activities
Sexual behaviour, risk practices for HIV transmission and knowledge of transmission routes were measured using data from behavioural monitoring studies conducted on people who inject drugs (PWID) [Reference Folch, Casabona and Espelt19], female sex workers (FSW) [Reference Folch, Casabona and Sanclemente20], MSM (from the ITACA cohort of HIV-negative MSM who attend a community centre [Reference Ferrer, Loureiro and Meulbroek12], and the EMIS Project [Reference Folch, Fernández-Dávila and Ferrer21]). Information was available for different periods in each of the sources and data extraction was undertaken accordingly, collecting information on testing frequency, access to healthcare, drug consumption, condom use and knowledge about HIV transmission routes. This last item was built from responses given to questions about knowledge of HIV transmission. Data on testing activity from 2002 to 2014 were extracted from community-based voluntary counselling and testing services (CBVCT), which perform voluntary, free and anonymous HIV antibody testing [Reference Fernàndez-Lopez, Rifà and Pujol22]. The rapid HIV test used by CBVCT services is Determine HIV 1/2, Abbott Laboratories, Abbott Park, IL, USA. We calculated the total number of people tested and the number of reactive test results by risk group and region of origin.
People aware of their positive HIV status
The primary data source was HIV and AIDS cases notified to the Catalan HIV Surveillance System from 2001 to 2013 [17]. We extracted information on the date of HIV diagnosis, socio-demographic characteristics, risk group and presentation with late and/or advanced HIV disease (including AIDS-defining conditions (ADC)), then described their trends.
People enrolled in HIV care, on ART and with viral load suppressed
Data used to estimate the proportion of people enrolled, on ART and virally suppressed in the HIV care cascade were derived from PISCIS cohort, which includes data on over 17000 HIV-positive people seen for follow-up in one of the participating centres in Catalonia and is more fully described elsewhere [Reference Jaén, Casabona and Esteve23]. Each of these steps was analysed by socio-demographic characteristics and risk population in people under active follow-up. In Catalonia healthcare and access to treatment are universal and free of charge for all people including migrants with irregular legal status.
Statistical analysis
Differences in the distribution of demographic characteristics (sex, age, education), risk population (PWID, FSW and MSM), sex behaviour and clinical characteristics, were assessed by region of origin, using Pearson's χ 2 test and Student's t test for categorical and continuous variables, respectively. Comparisons were made to provide insight into which factors were linked to HIV infection by region of origin. Correlates were determined using a regression model and the odds ratios, along with 95% confidence intervals (CIs) calculated are reported. HIV prevalence was reported for PWID, FSW and MSM. Denominator populations used to calculate rates of new HIV diagnoses per 100 000 population were derived from census data [24]. The ITACA cohort HIV incidence rate and corresponding 95% CIs were calculated using person-time measures. In the absence of reliable estimates of the numbers of migrants (diagnosed and undiagnosed) living with HIV in Catalonia, we constructed a modified cascade starting with the people who were diagnosed and linked to care. Subsequent steps were calculated by applying to the preceding stage a proportion estimated from surveillance data and the proportions retained in care, on ART and virally suppressed were derived from the PISCIS cohort. A fuller description of the methods has been published elsewhere [Reference Campbell, Ambrosioni and Miro25]. The level of significance was set at a P value of <0·05. Data analysis was performed using Stata 12. CollegeStation, TX: StataCorpLP.
RESULTS
People at risk and reached by prevention activities
Differences in HIV risk indicators by key population are shown in Table 1 stratified by migration status. Among PWID, the HIV prevalence was higher in Spanish-born people (35·9%) compared with migrants (22·4%) and a greater proportion of the Spanish-born population was knowledgeable about HIV transmission routes (69·7% vs. 77·7%) and reported better access to substance abuse outpatient treatment centres (69·8% vs. 31·0%), primary care (72·5% vs. 49·3%) and emergency departments (35·0% vs. 23·4%). Among FSW, HIV prevalence was higher among the Spanish-born than migrants (14·7% vs. 0·3%), Spanish-born FSW reporting higher proportions of illegal drug use (64·7%) and inconsistent condom use with clients (21·9%). Migrant FSW reported having poorer access to healthcare services than Spanish-born FSW (65·6% vs. 82·4%). Latin America was the most frequent region of origin for MSM in both EMIS and the ITACA cohort (53·5% and 57·9%, respectively). In the ITACA cohort between 2009 and 2011, 3544 participants with at least one follow-up visit or those who had a first visit no longer than a year prior to the date of data censoring were included in the analysis contributing 3567·09 person-years (p-y) of follow-up and 85 MSM seroconverted, giving an overall HIV incidence of 2·4 per 100 p-y (95% CI 1·9–2·9) and ranging from 1·21/100 (2009) to 3·1/100 p-y (2011). The incidence was higher among migrant (3·7/100 p-y) than Spanish-born MSM (1·7/100 p-y), yet a greater proportion of migrant MSM were knowledgeable about HIV transmission routes than Spanish-born MSM and had also been tested more frequently.
PWID, people who inject drugs; MSM, men who have sex with men; FSW, female sex workers; OTC, outpatient treatment centres; CI, confidence interval.
* High knowledge was defined as correctly answering all of the following questions: (1) Can you reduce the risk of HIV transmission by having sex with one partner who has not contracted HIV and has no other partners? (2) Can the risk of HIV transmission be reduced by using a condom every time a sexual intercourse is performed? (3) Can a healthy-looking person have HIV? (4) Can you get HIV from a mosquito bite? (5) Can you get HIV by sharing a meal with an HIV-positive person?
† Sufficient knowledge about routes of HIV transmission was considered if the individual answered in the affirmative that HIV is transmitted by the following three routes: (1) through used syringes, (2) by vaginal intercourse without a condom, (3) by anal intercourse without a condom.
‡ High knowledge was considered by correctly answering the following items: (1) you cannot be sure that someone has HIV by their physical appearance; (2) effective HIV treatment reduces the risk of HIV transmission; (3) HIV is not transmitted by kissing, even with a deep kiss, because saliva does not transmit the virus; (4) you can get HIV through your penis while practicing unprotected anal or vaginal active penetration (penetrate) with an infected partner, even without ejaculating; (5) you can get HIV through your anus during unprotected anal intercourse in passive penetration (being penetrated) with an infected partner.
CBVCTs have performed a total of 52 378 tests since 2002, the annual number of tests rising from 810 in 2002 to 9454 in 2014 and the proportion of migrants increasing by 93·5% in the same period. Of the 18 656 migrants (35·6%) tested, 55·3% were men and the most frequent regions of origin were Latin America (44·7%) and Western Europe (24·8%). Migrants made up a majority of MSW (male sex workers; 55·7%), PWID (78·8%) and FSW (87·7%). Test reactivity also varied by origin, with 3·9% (723/18 656) of migrants having a reactive test as compared with 2·0% (636/31 162) of the Spanish-born population.
People aware of their positive HIV status
Between 2001 and 2013, 9829 new HIV diagnoses were reported to the Catalan HIV surveillance system, 38·5% of whom were migrants. The HIV notification rate in Spanish-born people has remained stable throughout, with a median notification rate of 7·4 cases per 100 000 population. However, the proportion of migrants among notified HIV cases has increased progressively from 24% in 2001 to 41% in 2013 and although it has declined since 2011, the HIV notification rate among migrants was five times higher than that of the Spanish-born population in 2013 (Fig. 1). The epidemiological profile of migrants was different to that of the Spanish-born population (Table 2); there was a higher proportion of women (24·6% and 16·7%, respectively) and they were younger at diagnosis (median age of 33 vs. 37, respectively). In both migrants and Spanish-born people, the most frequent at-risk population was MSM (40% and 43%, respectively) and there were significant differences by region of origin. Whereas in people from Western Europe and Latin America the main risk population was MSM (65% and 60·4%, respectively), in people from Eastern Europe it was PWID (34·5%) and in those from SSA it was HTS (heterosexuals) in both men (46·3%) and women (37·6%). In the Spanish-born population, the proportion of late diagnoses was lower (50·4%) than in migrants (54·0%). People from SSA had the highest proportion of late diagnosis (63·7%) and advanced disease (43·4%). There were no significant differences in the proportion of ADC between migrants and natives, but the pattern of ADC did vary between them. The most common ADC among the Spanish-born population was Pneumocystis jirovecii pneumonia (30·9%), whereas among migrants it was tuberculosis (30·1%).
PWID, people who inject drugs; MSM, men who have sex with men; WE, Western Europe; EE, Eastern Europe; LAC, Latin America and the Caribbean; SSA, sub-Saharan Africa; NA, North Africa; OR, odds ratio; CI, confidence interval.
* χ 2 test.
† χ 2 test comparing migrants by region of origin with Spanish-born population.
‡ Percentages calculated using as a denominator the total number of migrants newly diagnosed with HIV, Catalonia, 2001–2013, except in the case of late and advanced diagnosis (see notes § and ¶).
§ Due to missing CD4 count data, the denominators for late and advanced diagnosis are: 5045 in natives, 3202 in migrants and 8247 in total.
¶ Due to missing CD4 count data, the denominators for region of origin are: 397 in WE, 231 in EE, 1518 in LAC, 775 in SSA and 153 in NA.
People enrolled in HIV care, on ART and with viral load suppressed
Table 3 shows the socio-demographic and clinical differences seen between migrants and the Spanish-born population under follow-up. At the end of 2012 there were 7248 HIV-positive patients under active follow-up in the PISCIS cohort, 6022 (83%) of whom had a known country of origin. Migrants accounted for 1828 (30·4%) of these patients, 53·6% (956) originating from Latin America or the Caribbean. As at enrolment, most people under follow-up were men (80·2%), the largest transmission group being MSM (42·6%). MSM made up 76·0% and 68·7% of migrants from Western Europe and Latin America/Caribbean, respectively, but only 7% of those from Africa.
PWID, people who inject drugs; MSM, men who have sex with men; ART, antiretroviral therapy; WE, Western Europe; EE, Eastern Europe; LAC, Latin America and the Caribbean; SSA and NA, sub-Saharan Africa and North Africa; IQR, interquartile range; VL, viral load.
* Only two had an unknown risk group.
† χ2 test.
‡ Percentages were calculated using as a denominator the total number of migrants from the PISCIS cohort, except in the case of AIDS-defining event where the denominator was the total number of people who had an indicator condition at enrolment in the PISCIS cohort.
§ Student's t test.
¶ Percentages were calculated using as a denominator the total number of new HIV diagnosis at enrolment in the PISCIS cohort.
Median time under follow-up was 5·5 years in Spanish-born people and 3·5 years in migrants. The longest follow-up time was for Africans (4·4 years) and the shortest for Eastern Europeans (3·1 years). Clinical follow-up 1 year after diagnosis was lower for migrants (82·8%) than for Spanish-born people (87·6%). Of those on follow-up and with known migration status, 93·7% of Spanish-born people were on ART as compared with 90·8% of migrants (P < 0·001). The proportion on ART varied by region of origin, though not reaching significance.
Data on viral suppression at the last visit was available for 5384/5477 patients on ART and with known migration status. A higher proportion of patients under follow-up with viral suppression were Spanish-born as compared with migrants (87·2% vs. 82·9%, P < 0·001). Viral suppression was highest in Africans (84·9%) and Western Europeans (84·8%) and lowest in Eastern Europeans (82·1%) and others (74·1%). Figure 2 shows the differences in the HIV care cascade by origin. As a percentage of the total under follow-up, migrants experience greater losses in retention in care (83% vs. 88% retention, respectively) and in the proportion on ART (93·7% vs. 90·8%) and virally suppressed (82·9% vs. 87·2%). When stratified by region of origin, the difference in the proportion on ART is greatest for the region ‘Others’ (80·7%) and Eastern Europeans (90·5%). The sum of these differences between migrants and Spanish-born people along the cascade means that only 67% of migrants diagnosed with HIV had viral suppression, 8% lower than the Spanish-born at 75%.
DISCUSSION
These are the first analyses to use multiple data sources to describe the differences between migrants and the Spanish-born population as they progress through the cascade of HIV prevention and care in Catalonia, Spain from notification to viral suppression. We show that disparities in health are evident between migrants and their native counterparts, with migrants having higher number of barriers to access HIV testing services as well as lower retention rates and proportions on ART, but it is worth noting that along the care cascade, variation between migrants form different regions is greater than that between migrants and the Spanish-born population.
People at risk and reached by prevention activities
This study found that among people reached by prevention activities, migrants experienced a higher number of barriers to access HIV testing services than the Spanish-born population and that these needs are driven primarily by shared risk factors. Our results showed that access to HIV testing differs by sub-population, results which are in line with the HIV testing trends for Spain as a whole [Reference Diez, Bleda and Varela26]. The general trend in Spain towards increased testing is not uniform across most-at-risk populations and actually decreases in some groups, such as FSW and PWID [Reference Diez, Bleda and Varela26]. Lower HIV testing uptake in migrants who are PWID can be explained by poor access to drug treatment centres [Reference Saigí, Espelt and Folch3] and healthcare [27], whereas among FSW this reduction may be part of a broader trend throughout Europe of worsening access to healthcare and an observed shift in the working environment from outdoors to indoors that hampers sex worker access to prevention programmes [28, 29]. Our research shows that migrant PWID and FSW reported health protective behaviours, but there is evidence that, over time, migrants tend to acquire the practices of their local-born counterparts; migrant FSW may start to consume illicit drugs [28], whereas migrants who are PWID may increase their consumption or adopt local consumption patterns [Reference Saigí, Espelt and Folch3]. Migrant MSM may engage in higher risk behaviours than Spanish-born MSM, such as condomless anal sex [Reference Diaz, Junquera and Esteban30, Reference Mimiaga, Biello and Robertson31]. Consistent with this, migrant MSM, especially those born in Latin America, have high HIV prevalence rates among those diagnosed with syphilis and gonorrhoea, as well as high prevalence and incidence rates of STIs in those newly diagnosed with HIV [Reference Diaz, Junquera and Esteban30]. Because migrant MSM perceive themselves as being at high risk for HIV, they are more likely to have ever been tested for HIV than the native MSM [Reference Fernández-Dávila, Folch and Ferrer32, Reference Hoyos, Fernández-Balbuena and de la Fuente33], an observation supported by our data, although untested migrant MSM are particularly hard to reach [Reference Fernández-Dávila, Folch and Ferrer32]. As has been described, members of key populations who are also migrants are an important risk group for HIV, highlighting a need to design socially and culturally heterogeneous primary prevention programmes that address the needs of these sub-populations. These interventions should be designed to integrate gender perspective into sexual and reproductive health programmes specially directed at Latin American MSM, and bring access to HIV testing as close to the community as possible.
People aware of their positive HIV status
The epidemiological characteristics of migrants aware of their HIV status were similar to that of the Spanish-born population, being mainly young and MSM. However, consistent with data published from the rest of Spain, migrants are not a homogeneous group, their epidemiological characteristics reflecting those of the country of origin [Reference Caro-Murillo, Castilla Catalán and Del Amo Valero34, Reference Hernando Rovirola, Ortiz-Barreda and Galán Montemayor35]. In Europe, recent data show that nearly two-fifths of all HIV cases reported between 2007 and 2012 were migrants [Reference Hernando, Alvárez-Del Arco and Alejos10]. Although the biggest group of newly diagnosed migrants is still from SSA, the proportion is falling, especially in women [Reference Hernando, Alvárez-Del Arco and Alejos10]. At the same time, HIV diagnoses in people who have moved from one European country to another or from Latin America, Asia and the Middle East have continued to rise. Many of those born in the latter countries are MSM. Across Europe, there are now as many HIV diagnoses in migrant MSM as in migrant African women [Reference Hernando, Alvárez-Del Arco and Alejos10], indicating that the HIV European epidemic is now concentrated in MSM, with many MSM coming from Latin America. In our study, newly diagnosed migrants were more likely to present late (54·0%), especially in people from SSA. These findings concord with previous studies from Spain and in Europe that identify being a migrant as a risk factor for late HIV diagnosis and presentation for care [Reference Hernando, Alvárez-Del Arco and Alejos10, Reference Oliva, Díez and Galindo36, Reference Van Beckhoven, Florence and Ruelle37]. In Europe, people born in African, Asian and Latin American countries are the most likely to be diagnosed late with HIV [Reference Hernando, Alvárez-Del Arco and Alejos10]. Recently, European countries have made it increasingly difficult for migrants to access healthcare and this may negatively affect the late diagnosis rate [Reference Royo-Bordonada, Díez-Cornell and Llorente38]. Other barriers are related to the limited capacity of health services and providers to meet the specific needs of migrants, further limiting their access [27]. In the case of Spain, a country with mixed or universal healthcare systems, the main barriers are structural and organisational, such as inconsistent referral and coordination between service tiers [Reference Gil-González, Carrasco-Portiño and Vives-Cases39]. In addition, timely entry into care may be hampered by poor understanding of administrative procedures and/or language barriers [Reference Tanser, Bärnighausen and Vandormael13]. In order to help tackle all these barriers and ensure smooth progress along the HIV care continuum, health systems need to reduce differential access to care between migrants and Spanish-born people by designing HIV care programmes that take into consideration barriers due to culture, language and stigma. These programmes should include biomedical, behavioural and structural interventions that address the complex interplay of the underlying determinants of HIV transmission and would need to be implemented in the medium-to-long term to maximise their impact.
People enrolled in HIV care on antiretroviral ART and with viral load suppression
As described elsewhere in Europe and Spain [Reference Deblonde, Sasse and Del Amo11, Reference Tanser, Bärnighausen and Vandormael13, Reference Van Beckhoven, Florence and Ruelle37, Reference Monge, Alejos and Dronda40], this study also shows that a lower proportion of migrants are enrolled in HIV care, on ART and have viral suppression, as compared with the Spanish-born population. Explanations include unfamiliarity with the host nation, miscommunication with HIV service providers and inadequate knowledge of patient rights and obligations [Reference Tanser, Bärnighausen and Vandormael13]. Notwithstanding these discussions in the literature, our findings would suggest that in Catalonia at least, some of the differences between migrants from different regions (and by extension between migrants and the Spanish-born population) may be explained by differential patterns of migration rather than only differential access. Together with national statistical estimates of changing patterns of migration [24], our data provide evidence for this in the median duration of follow-up; Africans have the longest duration of follow-up because immigration from SSA has fallen off markedly since 2008 restricting the numbers of new SSA migrants, lengthening the median follow-up of those that remained. As a consequence, the probability of having been treated with ART increases. Conversely, those with the shortest median follow-up also have the lowest proportions on ART because they have had less time to be started on ART. Furthermore, the health-seeking behaviours of migrants are not always fully understood by service providers [Reference Tanser, Bärnighausen and Vandormael13]. In Switzerland, higher rates of loss to follow-up among migrants have been explained by legal status or deportations, individuals returning to their home countries, higher geographical mobility and barriers to regularly accessing services [Reference Thierfelder, Weber and Elzi41]. Several of these barriers have also been associated with poor viral suppression, and are further exacerbated by the high mobility of individuals [Reference Tanser, Bärnighausen and Vandormael13]. In order to facilitate uninterrupted access to treatment and provide realistic estimates for each step of the cascade, it is important that migrants are able to easily receive their HIV treatment at different facilities without being lost. People with diagnosed HIV, irrespective of their migration status can be better tracked across services and facilities where population-based cohorts are used or dynamic centralised registers set up [Reference Tanser, Bärnighausen and Vandormael13]. In Catalonia, there is still a substantial gap in the way migrants’ demographic and health information is collected and any improvements could also provide an opportunity to identify hidden disparities or inequalities in migrant's access to healthcare and better understand the determinants associated with loss to follow-up at successive stages of the cascade of HIV prevention and care in Catalonia.
Our study does have some limitations. The data are incomplete and come from different sources using different methods, making it difficult to generalise. Furthermore, available information is partial and not representative of all the different subpopulations of migrants across Catalonia. Despite this limitation, no other study has used so many different sources of information to describe the differences between migrants and the Spanish-born population as they progress through the cascade of HIV prevention and care. An important limitation is that we have not yet been able to study the differences in rates of undiagnosed HIV between migrants and the Spanish-born population. The various subgroup analyses completed for this study may not necessarily explain complex differences in global HIV epidemic dynamics among migrants, but they do demonstrate that high HIV prevalence rates among migrants are heterogeneous.
In conclusion, disparities in health are evident between migrants and their Spanish-born counterparts, with migrants having a higher number of barriers to access HIV testing services as well as lower retention rates and proportions on ART. Similar differences are also observed between migrants form different regions. Effective HIV testing and treatment programmes for migrants should be integrated into a balanced combination prevention framework that includes biomedical, behavioural and structural interventions that are stable in time and address the complex interplay of underlying determinants of HIV transmission and are especially tailored to migrant needs. All this requires unrestricted access to a continuum of HIV prevention, testing and care services, implemented through a multi-sectorial and participatory approach that takes into consideration the political, economic and social contexts.
ACKNOWLEDGEMENTS
The authors gratitude goes to all the Doctors who notified the HIV cases and to the HIV units which are treating patients in Catalonia – Spain, and also to all the professionals working in CBVCT services in Catalonia. This study received no specific grant from any funding agency.
DECLARATION OF INTEREST
None.