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Association between n-3 PUFA and lung function: results from the NHANES 2007–2012 and Mendelian randomisation study

Published online by Cambridge University Press:  26 January 2024

Jingli Li Open the ORCID record for Jingli Li [Opens in a new window] ,
Jian Sun ,
Lingjing Liu ,
Chunyi Zhang  and
Zixiang Liu
Jingli Li
Affiliation:
Department of Pulmonary and Critical Care Medicine, Shaoxing People’s Hospital, Shaoxing 312000, Zhejiang, People’s Republic of China
Jian Sun
Affiliation:
Department of Pulmonary and Critical Care Medicine, Shaoxing People’s Hospital, Shaoxing 312000, Zhejiang, People’s Republic of China
Lingjing Liu
Affiliation:
Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, People’s Republic of China
Chunyi Zhang
Affiliation:
Department of Pulmonary and Critical Care Medicine, Shaoxing People’s Hospital, Shaoxing 312000, Zhejiang, People’s Republic of China
Zixiang Liu*
Affiliation:
Department of Pulmonary and Critical Care Medicine, Shaoxing People’s Hospital, Shaoxing 312000, Zhejiang, People’s Republic of China
*
*Corresponding author: Zixiang Liu, email zxshaoxingrmyy@163.com
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Abstract

This study aimed to investigate the association between n-3 PUFA and lung function. First, a cross-sectional study was conducted based on the National Health and Nutrition Examination Survey (NHANES) 2007–2012 data. n-3 PUFA intake was obtained from 24-h dietary recalls. A multivariable linear regression model was used to assess the observational associations of n-3 PUFA intake with lung function. Subsequently, a two-sample Mendelian randomisation (MR) was performed to estimate the potential causal effect of n-3 PUFA on lung function. Genetic instrumental variables were extracted from published genome-wide association studies. Summary statistics about n-3 PUFA was from UK Biobank. Inverse variance weighted was the primary analysis approach. The observational study did not demonstrate a significant association between n-3 PUFA intake and most lung function measures; however, a notable exception was observed with significant findings in the highest quartile for forced vital capacity (FVC) and % predicted FVC. The MR results also showed no causal effect of circulating n-3 PUFA concentration on lung function (forced expiratory volume in one second (FEV1), β = 0·01301, se = 0·01932, P = 0·5006; FVC, β = −0·001894, se = 0·01704, P = 0·9115; FEV1:FVC, β = 0·03118, se = 0·01743, P = 0·07359). These findings indicate the need for further investigation into the impact of higher n-3 PUFA consumption on lung health.

Keywords

n-3 PUFALung functionNational Health and Nutrition Examination SurveyMendelian randomisation
Type
Research Article
Information
British Journal of Nutrition , Volume 131 , Issue 10 , 28 May 2024 , pp. 1720 - 1729
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society

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