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Dietary total antioxidant capacity is closely associated with skeletal muscle mass: a cross-sectional study

Published online by Cambridge University Press:  12 November 2024

Jie Zhang ,
Wendong Fang ,
Shuiping Chen  and
Lu Wang Open the ORCID record for Lu Wang [Opens in a new window]
Jie Zhang
Affiliation:
Clinical Laboratory Department, Lu’an People’s Hospital, Lu’an 237000, Anhui Province, People’s Republic of China
Wendong Fang
Affiliation:
The Fifth Medical Center of PLA General Hospital, The Fifth School of Clinical Medicine, Anhui Medical University, Hefei 230032, Anhui Province, People’s Republic of China
Shuiping Chen*
Affiliation:
The Fifth Medical Center of PLA General Hospital, The Fifth School of Clinical Medicine, Anhui Medical University, Hefei 230032, Anhui Province, People’s Republic of China
Lu Wang*
Affiliation:
Clinical Laboratory Department, Lu’an People’s Hospital, Lu’an 237000, Anhui Province, People’s Republic of China
*
Corresponding authors: Lu Wang; Email: [email protected]; Shuiping Chen; Email: [email protected]
Corresponding authors: Lu Wang; Email: [email protected]; Shuiping Chen; Email: [email protected]
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Abstract

Skeletal muscle is of great importance for human activity and quality of life, as its loss contributes greatly to immobilisation, especially for aged individuals. An increased dietary intake of antioxidant vitamins may be beneficial for muscle loss because of ageing. However, the quantitative relationship between total antioxidant capacity (TAC) of antioxidant vitamins and muscle mass is undetermined. Totally, 4009 participants from the National Health and Nutrition Examination Survey (NHANES) were included. Multivariate linear regression analysis was performed with demographic, lifestyle and dietary intake adjustment factors. The dose saturation effect was also determined by a saturation effect analysis. Subgroup analysis was performed for age and sex. In the fully adjusted model, per unit increase of dietary TAC was associated with an increase of 0·018 g/kg appendicular lean mass (95 % CI 0·007, 0·029), 0·014 g/kg trunk lean mass (95 % CI 0·004, 0·024) and 0·035 g/kg total lean mass (95 % CI 0·014, 0·055). TAC was associated with a decrease of 0·004 kg/kg total percent fat (95 % CI −0·006, −0·002), 0·005 kg/kg trunk percent fat (95 % CI −0·007, −0·002) and 0·003 kg/m2 BMI (95 % CI −0·006, −0·001) at the same time. Subgroup analysis indicated that women and adults < 50 years may experience the most significant association between TAC and skeletal muscle mass. We revealed a positive correlation between TAC and lean body mass and a negative association between TAC and body fat and BMI. Saturation values were found among people aged 40–59 years. Age and sex mediate these associations.

Keywords

Total antioxidant capacitySkeletal muscle massAgeingNHANES
Type
Research Article
Information
British Journal of Nutrition , Volume 132 , Issue 12 , 28 December 2024 , pp. 1674 - 1683
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Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society

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Footnotes

†

These authors contributed equally to this work.

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