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Published online by Cambridge University Press: 23 March 2020
Rare research was reported about assessing the effectiveness and safety of amisulpride in Chinese patients with schizophrenia before we performed the ESCAPE, a multicenter, single-arm, phase IV study (NCT01795183). This study is a cluster analysis of ESCAPE study.
To identify the effectiveness patterns of amisulpride in Chinese patients with schizophrenia.
To examine baseline characteristics of patients as potential predictors of effectiveness.
Time-series cluster analysis was performed to identify effectiveness trajectories bases on Positive and Negative Syndrome Scale (PANSS) scores in Chinese patients with schizophrenia received amisulpride for 8 weeks. Baseline characteristics of patients were examined.
Overall, 295 patients were included for efficacy analysis. Four response trajectories based on positive PANSS were identified (Figure 1): (1) rapid response (cluster 1); (2) gradual response (cluster 2); (3) sustained low level (cluster 3); (4) poor response (cluster 4). Age in cluster 4 was significantly higher than that in cluster 1 and cluster 3 (Table 1, P = 0.0025 and 0.0032, respectively). Similarly, four response trajectories based on negative PANSS were generated (Figure 2): (1) rapid response (cluster 1); (2) gradual response (cluster 2); (3) poor response with moderate PANSS (cluster 3); (4) poor response with high PANSS (cluster 4). Male to female ratio in cluster 1 was significantly lower than that in cluster 2 and cluster 3 (Table 2, P = 0.0042 and 0.0208, respectively).
For the first time, we obtained effectiveness patterns of amisulpride-treated Chinese patients. Age and gender may be predictors of effectiveness.
This study is being funded by Sanofi (China) Investment Co., Ltd.
Fig. 1 Time series clustering of PANSS positive score. Four clusters and fitting curves (thick lines) are presented.
Fig. 2 Time series clustering of PANSS negative score. Four clusters and fitting curves (thick lines) are presented.
Table 1 Age comparison of positive PANSS clusters.
Table 2 Gender comparison of negative PANSS clusters.
Fig. 1 Time series clustering of PANSS positive score. Four clusters and fitting curves (thick lines) are presented.
Fig. 2 Time series clustering of PANSS negative score. Four clusters and fitting curves (thick lines) are presented.
Table 1 Age comparison of positive PANSS clusters.
Table 2 Gender comparison of negative PANSS clusters.
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