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The impact of physical activity changes on exercise capacity and health-related quality of life in young patients with CHD: a 3-year follow-up study

Published online by Cambridge University Press:  11 December 2023

Hyun Jeong Kim Open the ORCID record for Hyun Jeong Kim [Opens in a new window] ,
Ja-kyoung Yoon Open the ORCID record for Ja-kyoung Yoon [Opens in a new window] ,
Min Jeong Cho Open the ORCID record for Min Jeong Cho [Opens in a new window] ,
Setor K. Kunutsor Open the ORCID record for Setor K. Kunutsor [Opens in a new window] ,
Seong-Ho Kim Open the ORCID record for Seong-Ho Kim [Opens in a new window]  and
Sae Young Jae Open the ORCID record for Sae Young Jae [Opens in a new window]
Hyun Jeong Kim
Affiliation:
Department of Sport Science, University of Seoul, Seoul, South Korea
Ja-kyoung Yoon
Affiliation:
Department of Pediatrics, Sejong General Hospital, Bucheon, South Korea
Min Jeong Cho
Affiliation:
Department of Sport Science, University of Seoul, Seoul, South Korea
Setor K. Kunutsor
Affiliation:
Leicester Real World Evidence Unit, Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
Seong-Ho Kim
Affiliation:
Department of Pediatrics, Sejong General Hospital, Bucheon, South Korea
Sae Young Jae*
Affiliation:
Department of Sport Science, University of Seoul, Seoul, South Korea
*
Corresponding author: Sae Young Jae; Email: syjae@uos.ac.kr
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Abstract

Objective:

This study examined the relationship between changes in physical activity and their impact on exercise capacity and health-related quality of life over a 3-year span in patients with CHD.

Methods:

We evaluated 99 young patients with CHD, aged 13–18 years at the outset. Physical activity, health-related quality of life, and exercise capacity were assessed via questionnaires and peak oxygen uptake measurements at baseline and after 3 years; changes in measures were estimated between the two time points and categorised into quartiles. Participants were stratified according to achieved (active) or not-achieved (inactive) recommended levels of physical activity (≥150 minutes/week) at both time points.

Results:

Despite increases in physical activity, exercise capacity, and health-related quality of life over 3 years, the changes were not statistically significant (all p > 0.05). However, a positive association was found between physical activity changes and exercise capacity (ß = 0.250, p = 0.040) and health-related quality of life improvements (ß = 0.380, p < 0.001). Those with the most pronounced physical activity increase showed notable exercise capacity (p < 0.001) and health-related quality of life increases (p < 0.001) compared with patients with the largest decline in physical activity. The active-inactive category demonstrated a notable decline in exercise capacity compared to the active-active group, while the inactive-active group showed health-related quality of life improvements.

Conclusions:

Over 3 years, increased physical activity was consistently linked to increases in exercise capacity and health-related quality of life in patients with CHD, highlighting the potential of physical activity augmentation as an intervention strategy.

Keywords

Longitudinal studyCHDphysical activityexercise capacityhealth-related quality of life
Type
Original Article
Information
Cardiology in the Young , Volume 34 , Issue 5 , May 2024 , pp. 1063 - 1070
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Copyright
© The Author(s), 2023. Published by Cambridge University Press

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Footnotes

Hyun Jeong Kim and Ja-kyoung Yoon contributed equally to this work as co-first authors of this manuscript.

References

Marelli, A. Trajectories of care in congenital heart disease – the long arm of disease in the womb. J Intern Med 2020; 288: 390–399. DOI: 10.1111/joim.13048.CrossRefGoogle Scholar
van der Bom, T, Bouma, BJ, Meijboom, FJ, Zwinderman, AH, Mulder, BJ. The prevalence of adult congenital heart disease, results from a systematic review and evidence based calculation. Am Heart J 2012; 164: 568–575. DOI: 10.1016/j.ahj.2012.07.023.CrossRefGoogle ScholarPubMed
Duppen, N, Takken, T, Hopman, MTE, et al. Systematic review of the effects of physical exercise training programmes in children and young adults with congenital heart disease. Int J Cardiol 2013; 168: 1779–1787. DOI: 10.1016/j.ijcard.2013.05.086.CrossRefGoogle Scholar
Tran, D, Maiorana, A, Ayer, J, et al. Recommendations for exercise in adolescents and adults with congenital heart disease. Prog Cardiovasc Dis 2020; 63: 350–366. DOI: 10.1016/j.pcad.2020.03.002.CrossRefGoogle Scholar
van Deutekom, AW, Lewandowski, AJ. Physical activity modification in youth with congenital heart disease: a comprehensive narrative review. Pediatr Res 2021; 89: 1650–1658. DOI: 10.1038/s41390-020-01194-8.CrossRefGoogle ScholarPubMed
Wikner, A, Sandström, A, Rinnström, D, et al. Impaired exercise capacity and mortality risk in adults with congenital heart disease. JACC Adv 2023; 2: 10042. DOI: 10.1016/j.jacadv.2023.100422.CrossRefGoogle ScholarPubMed
Khan, AM, Paridon, SM, Kim, YY. Cardiopulmonary exercise testing in adults with congenital heart disease. Expert Rev Cardiovasc Ther 2014; 12: 863–872. DOI: 10.1586/14779072.2014.919223.CrossRefGoogle ScholarPubMed
Diller, GP, Dimopoulos, K, Okonko, D, et al. Exercise intolerance in adult congenital heart disease: comparative severity, correlates, and prognostic implication. Circulation 2005; 112: 828–835. DOI: 10.1161/circulationaha.104.529800.CrossRefGoogle ScholarPubMed
Villaseca-Rojas, Y, Varela-Melo, J, Torres-Castro, R, et al. Exercise capacity in children and adolescents with congenital heart disease: a systematic review and meta-analysis. Front Cardiovasc Med 2022; 9: 874700. DOI: 10.3389/fcvm.2022.874700.CrossRefGoogle ScholarPubMed
Swan, L, Hillis, WS. Exercise prescription in adults with congenital heart disease: a long way to go. Heart 2000; 83: 685–687. DOI: 10.1136/heart.83.6.685.CrossRefGoogle ScholarPubMed
O’Byrne, ML, Mercer-Rosa, L, Ingall, E, McBride, MG, Paridon, S, Goldmuntz, E. Habitual exercise correlates with exercise performance in patients with conotruncal abnormalities. Pediatr Cardiol 2013; 34: 853–860. DOI: 10.1007/s00246-012-0556-5.CrossRefGoogle ScholarPubMed
Ladak, LA, Hasan, BS, Gullick, J, Gallagher, R. Health-related quality of life in congenital heart disease surgery in children and young adults: a systematic review and meta-analysis. Arch Dis Child 2019; 104: 340–347. DOI: 10.1136/archdischild-2017-313653.CrossRefGoogle Scholar
Brudy, L, Meyer, M, Oberhoffer, R, Ewert, P, Müller, J. Move more - be happier? Physical activity and health-related quality of life in children with congenital heart disease. Am Heart J 2021; 241: 68–73. DOI: 10.1016/j.ahj.2021.07.004.CrossRefGoogle ScholarPubMed
Kim, HJ, Jae, SY, Choo, J, et al. Mediating effects of exercise capacity on the association between physical activity and health-related quality of life among adolescents with complex congenital heart disease. Am J Hum Biol 2019; 31: e23297. DOI: 10.1002/ajhb.23297.CrossRefGoogle ScholarPubMed
Müller, J, Hess, J, Hager, A. Daily physical activity in adults with congenital heart disease is positively correlated with exercise capacity but not with quality of life. Clin Res Cardiol 2012; 101: 55–61. DOI: 10.1007/s00392-011-0364-6.CrossRefGoogle Scholar
Warnes, CA, Williams, RG, Bashore, TM, et al. ACC/AHA 2008 Guidelines for the Management of Adults with Congenital Heart Disease: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to develop guidelines for the management of adults with congenital heart disease). Circulation 2008; 118: 2395–2451. DOI: 10.1161/circulationaha.108.190811.CrossRefGoogle Scholar
World Health Organization. Global Physical Activity Questionnaire (GPAQ) Analysis Guide. World Health Organization, Geneva, 2012.Google Scholar
Varni, JW, Seid, M, Knight, TS, Uzark, K, Szer, IS. The PedsQL 4.0 Generic Core Scales: sensitivity, responsiveness, and impact on clinical decision-making. J Behav Med 2002; 25: 175–193. DOI: 10.1023/a:1014836921812.CrossRefGoogle ScholarPubMed
Fredriksen, PM, Veldtman, G, Hechter, S, et al. Aerobic capacity in adults with various congenital heart diseases. Am J Cardiol 2001; 87: 310–314. DOI: 10.1016/s0002-9149(00)01364-3.CrossRefGoogle ScholarPubMed
Jenkins, PC, Chinnock, RE, Jenkins, KJ, et al. Decreased exercise performance with age in children with hypoplastic left heart syndrome. J Pediatr 2008; 152: 507–512. DOI: 10.1016/j.jpeds.2007.09.050.CrossRefGoogle ScholarPubMed
Moons, P, Luyckx, K. Quality-of-life research in adult patients with congenital heart disease: current status and the way forward. Acta Paediatr 2019; 108: 1765–1772. DOI: 10.1111/apa.14876.CrossRefGoogle ScholarPubMed
Lenz, B. The transition from adolescence to young adulthood: a theoretical perspective. J Sch Nurs 2001; 17: 300–306. DOI: 10.1177/10598405010170060401.CrossRefGoogle ScholarPubMed
Moons, P, Bratt, EL, De Backer, J, et al. Transition to adulthood and transfer to adult care of adolescents with congenital heart disease: a global consensus statement of the ESC Association of Cardiovascular Nursing and Allied Professions (ACNAP), the ESC Working Group on Adult Congenital Heart Disease (WG ACHD), the Association for European Paediatric and Congenital Cardiology (AEPC), the Pan-African Society of Cardiology (PASCAR), the Asia-Pacific Pediatric Cardiac Society (APPCS), the Inter-American Society of Cardiology (IASC), the Cardiac Society of Australia and New Zealand (CSANZ), the International Society for Adult Congenital Heart Disease (ISACHD), the World Heart Federation (WHF), the European Congenital Heart Disease Organisation (ECHDO), and the Global Alliance for Rheumatic and Congenital Hearts (Global ARCH). Eur Heart J 2021; 42: 4213–4223. DOI: 10.1093/eurheartj/ehab388.CrossRefGoogle Scholar
Apers, S, Luyckx, K, Moons, P. Quality of life in adult congenital heart disease: what do we already know and what do we still need to know? Curr Cardiol Rep 2013; 15: 407. DOI: 10.1007/s11886-013-0407-x.CrossRefGoogle Scholar
Atz, AM, Zak, V, Mahony, L, et al. Longitudinal outcomes of patients with single ventricle after the Fontan procedure. J Am Coll Cardiol 2017; 69: 2735–2744. DOI: 10.1016/j.jacc.2017.03.582.CrossRefGoogle ScholarPubMed
Williams, CA, Wadey, C, Pieles, G, Stuart, G, Taylor, RS, Long, L. Physical activity interventions for people with congenital heart disease. Cochrane Database Syst Rev 2020; 10: Cd013400. DOI: 10.1002/14651858.CD013400.pub2.Google ScholarPubMed
Dulfer, K, Helbing, WA, Duppen, N, Utens, EM. Associations between exercise capacity, physical activity, and psychosocial functioning in children with congenital heart disease: a systematic review. Eur J Prev Cardiol 2014; 21: 1200–1215. DOI: 10.1177/2047487313494030.CrossRefGoogle ScholarPubMed
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