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Coffee consumption with different additives and types, genetic variation in caffeine metabolism and new-onset acute kidney injury
Published online by Cambridge University Press: 11 November 2024
Abstract
We aimed to evaluate the association of coffee consumption with different additives, including milk and/or sweetener (sugar and/or artificial sweetener), and different coffee types, with new-onset acute kidney injury (AKI), and examine the modifying effects of genetic variation in caffeine metabolism. 194 324 participants without AKI at baseline in the UK Biobank were included. The study outcome was new-onset AKI. During a median follow-up of 11·6 years, 5864 participants developed new-onset AKI. Compared with coffee non-consumers, a significantly lower risk of new-onset AKI was found in coffee consumers adding neither milk nor sugar to coffee (hazard ratio (HR), 0·86; 95 % CI, 0·78, 0·94) and adding only milk to coffee (HR,0·83; 95 % CI, 0·78, 0·89), but not in coffee consumers adding only sweetener (HR,1·14; 95 % CI, 0·99, 1·31) and both milk and sweetener to coffee (HR,0·96; 95 % CI, 0·89, 1·03). Moreover, there was a U-shaped association of coffee consumption with new-onset AKI, with the lowest risk at 2–3 drinks/d, in unsweetened coffee (no additives or milk only to coffee), but no association was found in sweetened coffee (sweetener only or both milk and sweetener to coffee). Genetic variation in caffeine metabolism did not significantly modify the association. A similar U-shaped association was found for instant, ground and decaffeinated coffee consumption in unsweetened coffee consumers, but not in sweetened coffee consumers. In conclusion, moderate consumption (2–3 drinks/d) of unsweetened coffee with or without milk was associated with a lower risk of new-onset AKI, irrespective of coffee type and genetic variation in caffeine metabolism.
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- © The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society
References
Ronco, C, Bellomo, R & Kellum, JA (2019) Acute kidney injury. Lancet 394, 1949–1964.CrossRefGoogle ScholarPubMed
Kaddourah, A, Basu, RK, Bagshaw, SM, et al. (2017) Epidemiology of acute kidney injury in critically ill children and young adults. N Engl J Med 376, 11–20.CrossRefGoogle ScholarPubMed
Shah, S, Leonard, AC, Harrison, K, et al. (2020) Mortality and recovery associated with kidney failure due to acute kidney injury. Clin J Am Soc Nephrol 15, 995–1006.CrossRefGoogle ScholarPubMed
Wald, R, Quinn, RR, Luo, J, et al. (2009) Chronic dialysis and death among survivors of acute kidney injury requiring dialysis. JAMA 302, 1179–1185.CrossRefGoogle ScholarPubMed
Kidney Disease: Improving Global Outcomes (KDIGO) (2012) Summary of recommendation statements. Kidney Int Suppl 2, 8–12.CrossRefGoogle Scholar
Tögel, F & Westenfelder, C (2014) Recent advances in the understanding of acute kidney injury. F1000Prime Rep 6, 83.CrossRefGoogle ScholarPubMed
Sharfuddin, AA & Molitoris, BA (2011) Pathophysiology of ischemic acute kidney injury. Nat Rev Nephrol 7, 189–200.CrossRefGoogle ScholarPubMed
Christ, A, Lauterbach, M & Latz, E (2019) Western diet and the immune system: an inflammatory connection. Immunity 51, 794–811.CrossRefGoogle ScholarPubMed
Jeon, J, Lee, K, Yang, KE, et al. (2021) Dietary modification alters the intrarenal immunologic micromilieu and susceptibility to ischemic acute kidney injury. Front Immunol 12, 621176.CrossRefGoogle ScholarPubMed
Liu, M, Zhang, Y, Ye, Z, et al. (2024) Evaluation of the association between coffee consumption including type (instant, ground) and addition of milk or sweeteners and new-onset hypertension and potential modifiers. J Acad Nutr Diet S2212-2672(24)00913-4 (Epub ahead of print).CrossRefGoogle Scholar
Voskoboinik, A, Koh, Y & Kistler, PM (2019) Cardiovascular effects of caffeinated beverages. Trends Cardiovasc Med 29, 345–350.CrossRefGoogle ScholarPubMed
Kalthoff, S, Landerer, S, Reich, J, et al. (2017) Protective effects of coffee against oxidative stress induced by the tobacco carcinogen benzo[α]pyrene. Free Radic Biol Med 108, 66–76.CrossRefGoogle Scholar
Metro, D, Cernaro, V, Santoro, D, et al. (2017) Beneficial effects of oral pure caffeine on oxidative stress. J Clin Transl Endocrinol 10, 22–27.Google ScholarPubMed
Kalthoff, S, Ehmer, U, Freiberg, N, et al. (2010) Coffee induces expression of glucuronosyltransferases by the aryl hydrocarbon receptor and Nrf2 in liver and stomach. Gastroenterology 139, 1699–1710, 1710.e1–2.CrossRefGoogle ScholarPubMed
Butt, MS & Sultan, MT (2011) Coffee and its consumption: benefits and risks. Crit Rev Food Sci Nutr 51, 363–373.CrossRefGoogle ScholarPubMed
Tommerdahl, KL, Hu, EA, Selvin, E, et al. (2022) Coffee consumption may mitigate the risk for acute kidney injury: results from the atherosclerosis risk in communities study. Kidney Int Rep 7, 1665–1672.CrossRefGoogle ScholarPubMed
Gan, X, Ye, Z, Zhang, Y, et al. (2024) Sweetened beverages and atrial fibrillation in people with prediabetes or diabetes. Diabetes Obes Metab 26, 5147–5156.CrossRefGoogle ScholarPubMed
Liu, M, Yang, S, Ye, Z, et al. (2023) Tea consumption and new-onset acute kidney injury: the effects of milk or sweeteners addition and caffeine/coffee. Nutrients 15, 2201.CrossRefGoogle ScholarPubMed
Meng, Y, Li, S, Khan, J, et al. (2021) Sugar- and artificially sweetened beverages consumption linked to type 2 diabetes, cardiovascular diseases, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective cohort studies. Nutrients 13, 2636.CrossRefGoogle ScholarPubMed
Xiang, H, Liu, M, Zhou, C, et al. (2024) Tea consumption, milk or sweeteners addition, genetic variation in caffeine metabolism, and incident venous thromboembolism. Thromb Haemost s-0044-1786819. (Epublication ahead of print version 10 May 2024).Google Scholar
He, P, Zhang, Y, Ye, Z, et al. (2023) A healthy lifestyle, Life’s Essential 8 scores and new-onset severe NAFLD: a prospective analysis in UK Biobank. Metabolism 146, 155643.CrossRefGoogle ScholarPubMed
He, P, Ye, Z, Liu, M, et al. (2023) Association of handgrip strength and/or walking pace with incident chronic kidney disease: a UK Biobank observational study. J Cachexia Sarcopenia Muscle 14, 805–814.CrossRefGoogle ScholarPubMed
Zhou, C, He, P, Ye, Z, et al. (2022) Relationships of serum 25-hydroxyvitamin D concentrations, diabetes, genetic susceptibility, and new-onset chronic kidney disease. Diabetes Care 45, 2518–2525.CrossRefGoogle ScholarPubMed
He, P, Zhou, C, Ye, Z, et al. (2023) Walking pace, handgrip strength, age, APOE genotypes, and new-onset dementia: the UK Biobank prospective cohort study. Alzheimers Res Ther 15, 9.CrossRefGoogle ScholarPubMed
Liu, M, Gan, X, Ye, Z, et al. (2023) Association of accelerometer-measured physical activity intensity, sedentary time, and exercise time with incident Parkinson’s disease. NPJ Digit Med 6, 224.CrossRefGoogle ScholarPubMed
Sudlow, C, Gallacher, J, Allen, N, et al. (2015) UK Biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med 12, e1001779.CrossRefGoogle ScholarPubMed
Ye, Z, Zhang, Y, Zhang, Y, et al. (2024) Large-scale proteomics improve prediction of chronic kidney disease in people with diabetes. Diabetes Care 47, 1757–1763.CrossRefGoogle ScholarPubMed
Seidelmann, SB, Claggett, B, Cheng, S, et al. (2018) Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis. Lancet Public Health 3, e419–28.CrossRefGoogle ScholarPubMed
Zhou, C, Zhang, Z, Liu, M, et al. (2021) Dietary carbohydrate intake and new-onset diabetes: a nationwide cohort study in China. Metabolism 123, 154865.CrossRefGoogle ScholarPubMed
Liu, M, Gan, X, He, P, et al. (2024) Dietary folate status among Chinese adults and its association with chronic kidney disease prevalence. Precision Nutr 3, e00079.Google Scholar
Liu, B, Young, H, Crowe, FL, et al. (2011) Development and evaluation of the Oxford WebQ, a low-cost, web-based method for assessment of previous 24 h dietary intakes in large-scale prospective studies. Public Health Nutr 14, 1998–2005.CrossRefGoogle ScholarPubMed
Liu, M, He, P, Ye, Z, et al. (2024) Association of handgrip strength and walking pace with incident Parkinson’s disease. J Cachexia Sarcopenia Muscle 15, 198–207.CrossRefGoogle ScholarPubMed
Inoue-Choi, M, Ramirez, Y, Cornelis, MC, et al. (2022) Tea consumption and all-cause and cause-specific mortality in the UK Biobank: a prospective cohort study. Ann Intern Med 175, 1201–1211.CrossRefGoogle ScholarPubMed
Bycroft, C, Freeman, C, Petkova, D, et al. (2018) The UK Biobank resource with deep phenotyping and genomic data. Nature 562, 203–209.CrossRefGoogle ScholarPubMed
Zhang, YB, Chen, C, Pan, XF, et al. (2021) Associations of healthy lifestyle and socioeconomic status with mortality and incident cardiovascular disease: two prospective cohort studies. BMJ 373, n604.CrossRefGoogle ScholarPubMed
Eastwood, SV, Mathur, R, Atkinson, M, et al. (2016) Algorithms for the capture and adjudication of prevalent and incident diabetes in UK Biobank. PLoS ONE 11, e0162388.CrossRefGoogle ScholarPubMed
Zhang, Y, Zhang, Y, Ye, Z, et al. (2024) Mobile phone use and risks of overall and 25 site-specific cancers: a prospective study from the UK Biobank study. Cancer Epidemiol Biomarkers Prev 33, 88–95.CrossRefGoogle ScholarPubMed
Wołyniec, W, Szwarc, A, Kasprowicz, K, et al. (2022) Impact of hydration with beverages containing free sugars or xylitol on metabolic and acute kidney injury markers after physical exercise. Front Physiol 13, 841056.CrossRefGoogle ScholarPubMed
Zhang, Z, Hu, G, Caballero, B, et al. (2011) Habitual coffee consumption and risk of hypertension: a systematic review and meta-analysis of prospective observational studies. Am J Clin Nutr 93, 1212–1219.CrossRefGoogle ScholarPubMed
Olthof, MR, Hollman, PC, Zock, PL, et al. (2001) Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans. Am J Clin Nutr 73, 532–538.CrossRefGoogle ScholarPubMed
Verhoef, P, Pasman, WJ, Van Vliet, T, et al. (2002) Contribution of caffeine to the homocysteine-raising effect of coffee: a randomized controlled trial in humans. Am J Clin Nutr 76, 1244–1248.CrossRefGoogle Scholar
Hsu, CY, Ordoñez, JD, Chertow, GM, et al. (2008) The risk of acute renal failure in patients with chronic kidney disease. Kidney Int 74, 101–107.CrossRefGoogle ScholarPubMed
Long, Y, Zhen, X, Zhu, F, et al. (2017) Hyperhomocysteinemia exacerbates cisplatin-induced acute kidney injury. Int J Biol Sci 13, 219–231.CrossRefGoogle ScholarPubMed
Chertow, GM, Burdick, E, Honour, M, et al. (2005) Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol 16, 3365–3370.CrossRefGoogle ScholarPubMed
Coca, SG, Singanamala, S & Parikh, CR (2012) Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis. Kidney Int 81, 442–448.CrossRefGoogle ScholarPubMed
Ye et al. supplementary material
Ye et al. supplementary material
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