Hostname: page-component-cd9895bd7-gxg78 Total loading time: 0 Render date: 2024-12-18T11:49:43.349Z Has data issue: false hasContentIssue false
  • English
  • Français

Glucose-dependent insulinotropic polypeptide concentration is influenced by the proportion of palmitic acid in the sn-2 position of dietary TAGs

Published online by Cambridge University Press:  14 October 2011

A. Filippou ,
S. E. Berry ,
S. Baumgartner ,
R. P. Mensink  and
T. A. B. Sanders
A. Filippou
Affiliation:
Diabetes and Nutritional Sciences Division, King's College London, Franklin-Wilkins Building, London SE1 9NH
S. E. Berry
Affiliation:
Diabetes and Nutritional Sciences Division, King's College London, Franklin-Wilkins Building, London SE1 9NH
S. Baumgartner
Affiliation:
Nutrition and Toxicology Institute Maastricht, University of Maastricht, Netherlands
R. P. Mensink
Affiliation:
Nutrition and Toxicology Institute Maastricht, University of Maastricht, Netherlands
T. A. B. Sanders
Affiliation:
Diabetes and Nutritional Sciences Division, King's College London, Franklin-Wilkins Building, London SE1 9NH
Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content. As you have access to this content, full HTML content is provided on this page. A PDF of this content is also available in through the ‘Save PDF’ action button.
Type
Abstract
Information
Proceedings of the Nutrition Society , Volume 70 , Issue OCE4: Summer Meeting, 4–6 July 2011, 70th Anniversary: From plough through practice to policy , 2011 , E161
Copyright
Copyright © The Authors 2011

Plant and animal sources of palmitic acid differ in TAG structure and this may influence their respective effects on postprandial metabolism(Reference Berry, Woodward, Yeoh, Miller and Sanders1). Palmitic acid is found predominantly in the sn-2 position in animal fats, but predominantly in the sn-1 and sn-3 positions in plant fats. Dietary TAG is a potent stimulator of glucose-dependent insulinotropic polypeptide (GIP) in human subjects(Reference Drucker2); however, the effects of TAG structure on its release are uncertain. Postprandial changes in plasma TAG (8 h) and GIP (3 h) concentrations were assessed following four meals containing 50 g test fat provided as high oleic sunflower oil (HOS) (control), palm olein (PO), randomly interesterified palm olein (IPO) and lard using a randomised crossover design in healthy men (n 25) and women (n 25). The lard contained a similar proportion of SFA (46.0 v. 44.8 wt%) and oleic acid (40.0 v. 42.6 wt%) to PO and IPO. The proportion of palmitic acid in the sn-2 position was 9.4%, 39.6% and 71.5% in the PO, IPO and lard, respectively.

Bars with different letters are significantly different from each other P<0.01; Bonferroni comparison test.

GIP secretion was decreased by fats with a high content of palmitic acid in the sn-2 position (lard and IPO) compared to control and PO. The percentage differences (95% CI) for the integrated area under the curve compared with the control were: lard −28.4% (−41.9, −14.5; P<0.001); IPO −27.4 (−41.3, −14.3; P<0.001). Both IPO and lard showed a less rapid rise in plasma TAG compared with the control and PO. The integrated area under the curve for TAG (95% CI) following lard differed by −14.2% (−24.3, −4.1) v. PO and by −11.2% (−21.7, −0.9) v. control. These findings indicate that TAG rich in palmitic acid in the sn-2 position inhibit GIP release and that GIP release is associated with an early rise in plasma TAG. Furthermore, the physical structure of TAG may modulate the release of gut peptides and thus influence postprandial metabolism.

This work was supported by the Malaysian Palm Oil Board.

References

1.Berry, SE, Woodward, R, Yeoh, C, Miller, GJ & Sanders, TA (2007) Lipids 42, 315–323.CrossRefGoogle Scholar
2.Drucker, DJ (2007) J Clin Invest 117, 24–3.CrossRefGoogle Scholar