Behavioral Genetics in the Postgenomic Era. Edited by Robert Plomin, John C. DeFries, Ian W. Craig & Peter McGuffin. Washington, DC: American Psychological Association. 2003. 608 pp. US$49.95 (members), $59.95 (non-members) (hb). ISBN 1 55798 926 5

The closing years of the 20th century saw molecular genetic approaches prove successful in identifying genes involved in a large number of rare disorders and traits that show a simple, Mendelian pattern of inheritance. In the opening years of the new millennium human geneticists are applying the powerful approaches and knowledge emanating from the human genome project to tackle the more challenging problem of genetically complex disorders and traits - common (or universal) characteristics that show substantial variation within human populations, and that do not have a simple pattern of inheritance; these are disorders and traits that are likely to follow some form of multifactorial model in which a combination of susceptibility genes and environmental factors act and interact to determine the expression of the trait. Most clinical psychiatrists will immediately recognise that many psychiatric disorders fall into this category; furthermore, so do most normal behavioural traits (including general and specific cognitive abilities and personality variables). As the media frequently remind us, the human genome project continues to deliver increasingly powerful resources and tools that can be used to investigate such disorders - including a working draft of the sequence of DNA in the human genome, detailed catalogues of the common variants in the DNA sequence and increasing numbers of annotated genes (i.e. identified DNA sequences that code for genes for which the expression profile and protein product are known and characterised). This will make the coming years an exciting time for all researchers and clinicians interested in psychiatric and behavioural disorders, because application of this knowledge will lead to the identification of genes and environmental factors influencing these traits.

The publication of Behavioral Genetics in the Postgenomic Era is therefore timely. This nicely presented, edited volume arose from a meeting coordinated by the Wellcome Trust: the authors include many of the leading clinical and basic scientists within the field of behavioural genetics, and its scope appropriately represents current research within this area. According to the flyleaf, this book sets itself the goal of assessing the current status and likely future directions in genetic research on behaviour. This goal is met within its 600 pages, and a broad range of theoretical and trait-specific topics are covered. The book focuses on behavioural traits rather than on psychiatric disorders. It is arranged in 26 chapters, divided into nine sections. The first six chapters provide orientation and theoretical background information regarding molecular, statistical and design aspects relevant to behavioural genetics. This is followed by sections on learning and memory in mice, human cognitive abilities, cognitive disabilities, psychopharmacology, personality, and a limited coverage of psychopathologic topics-chapters on attention-deficit hyperactivity disorder, schizophrenia, mood disorders and dementia. A helpful glossary is included for the non-specialist.

A minor criticism is that the style and degree of specialisation of chapters are variable; consequently it will be easier to use the book for reference to individual topics rather than to read it sequentially as an overview. Undoubtedly, it would be an excellent addition to any psychiatric library. Consistent with the title, the coverage of the main psychiatric disorders is relatively limited, and readers mainly interested in psychiatric genetics will find more extensive coverage and focus on disorders in Psychiatric Genetics and Genomics (McGuffin et al, 2002).