This study sheds new light on the different characteristics of social networks for COVID-19 in European regions. This study explores six countries (the United Kingdom, Spain, Italy, Germany, France, and Sweden) by employing social network analysis for Twitter. First, this study finds that European countries show different characteristics for social networks with regard to COVID-19. For example, the UK has only national key players, France shows a majority of national key players, and other countries have all global key players. Donald Trump played an important role in the social networks of Italy, Germany and Sweden while he was the US president. Second, European countries demonstrate different social networks for groups. For example, the UK shows the most active communications across groups, whereas Germany shows the least communication networks across groups. Lastly, European countries reveal highly different interests regarding COVID-19. For example, the UK is more interested in the epidemic and vaccines, Germany focuses on schools and studies, and Sweden cares more about herd immunity and lockdown.