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Maternal, antenatal and birth-associated determinants of neonatal iron stores

Published online by Cambridge University Press:  24 November 2016

E.K. McCarthy ,
L.C. Kenny ,
J.O’B. Hourihane ,
A.D. Irvine ,
D.M. Murray  and
M. Kiely
E.K. McCarthy
Affiliation:
Cork Centre for Vitamin D and Nutrition Research, University College Cork, Republic of Ireland The Irish Centre for Fetal and Neonatal Translational Research (INFANT), University College Cork, Republic of Ireland
L.C. Kenny
Affiliation:
The Irish Centre for Fetal and Neonatal Translational Research (INFANT), University College Cork, Republic of Ireland Department of Obstetrics and Gynaecology, University College Cork, Republic of Ireland
J.O’B. Hourihane
Affiliation:
The Irish Centre for Fetal and Neonatal Translational Research (INFANT), University College Cork, Republic of Ireland Department of Paediatrics and Child Health, University College Cork, Republic of Ireland
A.D. Irvine
Affiliation:
Department of Clinical Medicine, Trinity College, Dublin, Republic of Ireland Department of Paediatric Dermatology, Our Lady's Children's Hospital, Dublin, Republic of Ireland National Children's Research Centre, Our Lady's Children's Hospital, Dublin, Republic of Ireland
D.M. Murray
Affiliation:
The Irish Centre for Fetal and Neonatal Translational Research (INFANT), University College Cork, Republic of Ireland Department of Paediatrics and Child Health, University College Cork, Republic of Ireland
M. Kiely
Affiliation:
Cork Centre for Vitamin D and Nutrition Research, University College Cork, Republic of Ireland The Irish Centre for Fetal and Neonatal Translational Research (INFANT), University College Cork, Republic of Ireland
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Abstract

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Abstract
Information
Proceedings of the Nutrition Society , Volume 75 , Issue OCE3: Summer Meeting, 11–14 July 2016, New technology in nutrition research and practice , 2016 , E82
Copyright
Copyright © The Authors 2016 

Serum ferritin concentrations measured in umbilical cord blood at birth are reflective of neonatal iron stores(Reference Siimes, Addiego and Dallman1). Iron stores in the neonate can track through to early childhood; those with the lowest ferritin concentrations at birth continue to have significantly lower ferritin concentrations up to two years of age(Reference Hay, Refsum and Whitelaw2). Moreover, low iron stores at birth have been associated with adverse neurodevelopmental outcomes later in childhood(Reference Tamura, Goldenberg and Hou3). The aim of this study was to identify maternal, antenatal and birth-associated determinants of serum ferritin concentrations at birth and to explore associations with iron status at two years of age.

Data were collected prospectively in the maternal-infant dyad Cork BASELINE Birth Cohort Study from 15 weeks’ gestation throughout early childhood(Reference O'Donovan, Murray and Hourihane4). Only participants with a complete maternal-infant dataset with matched blood samples collected from infants in the umbilical cord at birth and at the 24-month assessment were included (n = 413). Serum ferritin concentrations were measured at birth and at two years, with haemoglobin concentrations and mean corpuscular volume also measured at two years. Regression models were developed to identify independent determinants of cord serum ferritin concentrations.

Mean (SD) cord serum ferritin concentrations were 236·5 (136·1) μg/l. Delivery by Caesarean section (adj. estimate (95 % confidence interval (CI)); −41·8 (−72·6, −10·9)) and maternal obesity (BMI ≥ 30 kg/m2) at 15 weeks’ gestation (−66·4 (−106·9, −25·9), all P < 0·05) were inversely associated with cord ferritin concentrations. Low iron stores (ferritin < 76 µg/l (3)) at birth were observed in 8 % (n = 33) of infants. Maternal smoking at 15 weeks’ gestation (adj. odds ratio (95 % CI); 2·9 (1·2, 7·0)) and being born small-for-gestational age (3·4 (1·3, 8·9), all P < 0·05) were associated with an increased risk of low iron stores at birth. Maternal anaemia (haemoglobin < 110 g/l at 20 weeks’ gestation) was not a significant determinant of cord ferritin concentrations. Cord ferritin concentrations were positively associated with ferritin concentrations at two years (adj. estimate (95 % CI); 0·03 (0·02, 0·04), P < 0·001).

Delivery by Caesarean section, being born small-for-gestational age and an unhealthy maternal lifestyle, characterised by smoking and obesity in pregnancy, were all associated with significantly lower serum ferritin concentrations at birth, which tracked through to two years of age. This study has highlighted the importance of overall maternal health during pregnancy for neonatal iron status. As some of these determinants are modifiable lifestyle factors, public health policies targeting women of child-bearing age to improve nutrition and health outcomes should be prioritised for the health of the next generation.

Research supported by the National Children's Research Centre and Danone Nutricia Early Life Nutrition.

References

1.Siimes, MA, Addiego, JE Jr., Dallman, PR. (1974) Blood 43(4): 581–90.Google Scholar
2.Hay, G, Refsum, H, Whitelaw, A, et al. (2007) Am J Clin Nutr 86(1): 64–73.Google Scholar
3.Tamura, T, Goldenberg, RL, Hou, J, et al. (2002) J Pediatr 140(2): 165–70.Google Scholar
4.O'Donovan, SM, Murray, DM, Hourihane, JO, et al. (2015) Int J Epidemiol 44(3):764–75.Google Scholar