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Relationship of sperm motility with clinical outcome of percutaneous epididymal sperm aspiration–intracytoplasmic sperm injection in infertile males with congenital domestic absence of vas deferens: a retrospective study

Published online by Cambridge University Press:  27 July 2021

Zhong Jixiang Open the ORCID record for Zhong Jixiang [Opens in a new window] ,
Zhang Lianmei ,
Zuo Yanghua  and
Xue Huiying
Zhong Jixiang*
Affiliation:
Department of Infertility, Jiangsu Huaian Maternity and Children Hospital, Huaian, China
Zhang Lianmei
Affiliation:
Department of Pathology, The Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, Huaian, China
Zuo Yanghua
Affiliation:
Department of Infertility, Jiangsu Huaian Maternity and Children Hospital, Huaian, China
Xue Huiying
Affiliation:
Department of Infertility, Jiangsu Huaian Maternity and Children Hospital, Huaian, China
*
Author for correspondence: Zhong Jixiang, Department of Infertility, Jiangsu Huaian Maternity and Children Hospital, Huaian, China. E-mail: [email protected]
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Summary

Congenital domestic absence of vas deferens (CBAVD) is a common factor in male infertility, and percutaneous epididymal sperm aspiration (PESA) combined with intracytoplasmic sperm injection (ICSI) is a primary clinical treatment, but the effect of the sperm obtained on pregnancy outcome remains to be explored. This study aimed to investigate the relationship between sperm motility with clinical outcome of PESA–ICSI in infertile males with CBAVD. A cohort of 110 couples was enrolled. In total, 76 infertile males were included in the high motility group, while the remaining 34 males were placed in the low motility group. Clinical pregnancy, embryo implantation rate and live birth rate were included as the primary outcome. After all follow-ups, we found that the high motility group achieved higher normal fertilization rates, cleavage rates, transplantable embryo rates and high-quality embryo rates than those in low motility group (normal fertilization rate, 78.2 ± 11.7% vs. 70.5 ± 10.2%, P = 0.003; cleavage rate, 97.1 ± 2.9% vs. 92.3 ± 3.0%, P = 0.000; transplantable embryo rate, 66.8 ± 14.9% vs. 58.6 ± 12.6%, P = 0.009 and high-quality embryo rate, 49.9 ± 10.5% vs. 40.5 ± 11.2%, P = 0.000). Additionally, compared with the low motility group, the clinical pregnancy rates, embryo implantation rates, and live birth rates in the high motility group were significantly increased (pregnancy rate, 61.8% vs. 26.5%, P = 0.009; embryo implantation rate, 36.5% vs. 18.0%, P = 0.044; live birth rate, 55.3% vs. 17.6%, P = 0.000). We concluded that the motility of sperm obtained by PESA affected the clinical outcome of ICSI in infertile males with CBAVD.

Keywords

Congenital bilateral absence of vas deferensIntracytoplasmic sperm injectionLive birth ratePercutaneous epididymal sperm aspirationSperm motility
Type
Research Article
Information
Zygote , Volume 30 , Issue 2 , April 2022 , pp. 234 - 238
Copyright
© The Author(s), 2021. Published by Cambridge University Press

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