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The guanylyl cyclase receptors

Published online by Cambridge University Press:  16 July 2018

David L. Garbers
David L. Garbers*
Affiliation:
Cecil H. and Ida Green Center for Reproductive Biology Sciences, Howard Hughes Medical Institute, and the Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75235-9050, USA
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Extract

In the early 1980s both our group (Hansbrough & Garbers, 1981; Garbers et al., 1982) and that of Norio Suzuki (Suzuki et al., 1981) identified the active material in sea urchin egg conditioned media that could stimulate sperm motility and metabolism. In the sea urchins Hemicentrotus pulcherrimus or Strongylocentrotus purpuratus, the active material was a small peptide that we named speract, and the Suzuki group named this and subsequent peptides SAPs, for sperm activating peptides. Subsequently, both groups identified other peptides (see Suzuki & Yoshino, 1992 for review), one of the most interesting being one named resact, the active material in Arbacia punctulata egg conditioned media. This peptide turned out to be the first animal sperm chemoattractant identified (Ward et al., 1985a). A peptide also turned out to be the active principle that explained previous observations of Ward and Vacquier (Ward et al., 1985b; Suzuki et al., 1984) that egg conditioned media could cause the rapid dephosphorylation of a major membrane protein of spermatozoa. The apparent receptor for resact was later identified as a guanylyl cyclase, establishing a new paradigm for low-molecular-weight second messenger signalling, and the major phosphoprotein regulated by resact was also the receptor itself.

Type
Special Lecture for Citizens
Information
Zygote , Volume 8 , supplement S1: Proceedings of the International Symposium on Fertilization and Development of Sea Urchin and Marine Invertebrates , December 1999 , pp. S24 - S25
Copyright
Copyright © Cambridge University Press 1999

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References

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