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Toll-like receptor ligands and their combinations as adjuvants - current research and its relevance in chickens

Published online by Cambridge University Press:  10 March 2015

S.K. GUPTA ,
L.V. SINGH ,
M.M. CHELLAPPA  and
S. DEY
S.K. GUPTA*
Affiliation:
Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, Bareilly-243122 (U.P.), India
L.V. SINGH
Affiliation:
Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, Bareilly-243122 (U.P.), India
M.M. CHELLAPPA
Affiliation:
Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, Bareilly-243122 (U.P.), India
S. DEY
Affiliation:
Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, Bareilly-243122 (U.P.), India
*
Corresponding author: [email protected]
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Abstract

With the advancement in knowledge of innate immune functioning, toll-like receptors (TLRs) have emerged as potential adjuvant candidates. TLRs are one of the types of pattern recognition receptors (PRRs) that sense conserved signature molecules on invading pathogens. Detection of the pathogens via TLRs alerts the immune system of the host and helps in mounting a quick immune response against the invading pathogens. This property of TLR ligands may be exploited for the development of effective prophylactic agents against infectious chicken diseases. In this review the immunostimulatory effects of various TLRs will be discussed as well as their use as adjuvants in combination.

Keywords

chickenTLRsadjuvantTLR combinationssynergyantagonismcross-talk
Type
Reviews
Information
World's Poultry Science Journal , Volume 71 , Issue 1 , March 2015 , pp. 95 - 110
Copyright
Copyright © World's Poultry Science Association 2015 

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