Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-25T07:17:40.922Z Has data issue: false hasContentIssue false
  • English
  • Français

Prospects of royal jelly as a potential natural feed additive in poultry diets

Published online by Cambridge University Press:  17 July 2018

M. SAEED ,
S.A. KALHORO ,
M. NAVEED ,
F.U. HASSAN ,
M. UMAR ,
M. RASHID ,
S.A. MEMON ,
F. SOOMRO ,
M.A. ARAIN Open the ORCID record for M.A. ARAIN [Opens in a new window]  and
S. CHAO
M. SAEED
Affiliation:
Department of Animal Nutrition, College of Animal Sciences and Technology, Northwest A&F University, Yangling, China, 712100
S.A. KALHORO
Affiliation:
Faculty of Agriculture, Lasbela University of Agriculture, Water and Marine Sciences, 3800 Uthal, Balochistan, Pakistan
M. NAVEED
Affiliation:
Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, School of Pharmacy, Jiangsu Province, 211198, PRChina
F.U. HASSAN
Affiliation:
Institute of Animal and Dairy Sciences, Faculty of Animal Husbandry, University of Agriculture Faisalabad, Pakistan
M. UMAR
Affiliation:
Faculty of Veterinary and Animal Sciences, Lasbela University of Agriculture, Water and Marine Sciences, 3800, Uthal, Balochistan, Pakistan
M. RASHID
Affiliation:
Faculty of Agriculture, Lasbela University of Agriculture, Water and Marine Sciences, 3800 Uthal, Balochistan, Pakistan
S.A. MEMON
Affiliation:
Faculty of Agriculture, Lasbela University of Agriculture, Water and Marine Sciences, 3800 Uthal, Balochistan, Pakistan
F. SOOMRO
Affiliation:
Department of Veterinary parasitology, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University Tandojam, Pakistan
M.A. ARAIN
Affiliation:
Faculty of Veterinary and Animal Sciences, Lasbela University of Agriculture, Water and Marine Sciences, 3800, Uthal, Balochistan, Pakistan
S. CHAO*
Affiliation:
Department of Animal Nutrition, College of Animal Sciences and Technology, Northwest A&F University, Yangling, China, 712100
*
Corresponding author: [email protected]
Get access

Abstract

Royal Jelly (RJ) is product from bees that is used to feed larvae in the hive as well as a main nutritional source for the queen honey bee. It has various important biological activities including as an antioxidant, immunomodulatory, anti-inflammatory, antimicrobial, cholesterol-lowering, and growth promoter activities and has the ability for inhibition of certain enzymatic degradation. It can be used for the improvement of growth performance, gut health and quality and safety of animal products in poultry due to its antioxidant and immune modulating properties. The antioxidant activity of RJ is mainly due to the presence of polyphenolic compounds. It is an excellent source of B and C vitamins and folic acid. The mineral profile of RJ is useful as it contains major macro and micro minerals. Studies conducted on supplementation with RJ in poultry diets have shown a significant increase in body weight, egg production, and immune levels and is especially useful in organic production. Supplementation of RJ at the level of 10 and 15 mg/kg in layer diets positively influenced egg weight (by 5.0% and 4.8% respectively), egg production (10.5% and 11.0% respectively), weight gain of hens (7.0% and 6.5% respectively) and yolk pigmentation (9.5% and 9.7% respectively). Total leukocyte and erythrocyte counts in the diet containing 200 mg/kg RJ were significantly higher than the diet contained 100 mg/kg or the unsupplemented control group. However, the heterophil/lymphocyte ratio and heterophil percent were reduced in RJ-fed groups. Supplementing poultry diets with RJ offers an opportunity to maximise profit from safe and high quality poultry production.

Keywords

royal jellyfeed additivegrowth promotermeat qualityantimicrobialpoultry nutrition
Type
Review
Information
World's Poultry Science Journal , Volume 74 , Issue 3 , September 2018 , pp. 499 - 508
Copyright
Copyright © World's Poultry Science Association 2018 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

ABD-ALLAH, S.M. (2010) Effect of royal jelly on bovine sperm characteristics during post-thaw incubation in vitro. Revista Veterinaria 21: 81-85.Google Scholar
ABDEL-HAFEZ, S.M.N., RIFAAI, R.A. and ABDELZAHER, W.Y. (2017) Possible protective effect of royal jelly against cyclophosphamide induced prostatic damage in male albino rats; a biochemical, histological and immuno-histo-chemical study. Biomedicine & Pharmacotherapy 90: 15-23.Google Scholar
AHANGARI, Y.J., HASHEMI, S., AKHLAGHI, A., ATASHI, H., ESMAILI, Z., GHORBANI, M., MASTANI, R., AZADEGAN, A. and DAVOODI, H. (2013) Effect of in ovo injection of royal jelly on post-hatch growth performance and immune response in broiler chickens challenged with newcastle disease virus. Iranian Journal of Applied Animal Science 3: 201-206.Google Scholar
ARPÁŠOVÁ, H., HAŠČÍK, P., PISTOVÁ, V., MELLEN, M., GÁLIK, B. and FIK, M. (2016) The effect of propolis extract on internal quality parameters of table eggs. Animal Science and Biotechnologies 49: 10-15.Google Scholar
ASLAN, Z. and AKSOY, L. (2015) Anti-inflammatory effects of royal jelly on ethylene glycol induced renal inflammation in rats. International Brazalina Journal of Urology 41: 1008-1013.Google Scholar
BABAEI, S., RAHIMI, S., TORSHIZI, M.A.K., TAHMASEBI, G. and MIRAN, S.N.K. (2016) Effects of propolis, royal jelly, honey and bee pollen on growth performance and immune system of Japanese quails. Veterinary Research Forum 7: 13-20.Google Scholar
BARNUŢIU, L.I., MĂRGHITAŞ, L.A., DEZMIREAN, D.S., MIHAI, C.M. and BOBIŞ, O. (2011) Chemical composition and antimicrobial activity of royal jelly-review. Scientific Papers Animal Science and Biotechnologies 44: 67-72.Google Scholar
BÍLIKOVA, K., HUANG, S.C., LIN, I.P., ŠIMUTH, J. and PENG, C.C. (2015) Structure and antimicrobial activity relationship of royalisin, an antimicrobial peptide from royal jelly of apis mellifera. Peptides 68: 190-196.Google Scholar
BLUM, M.S., NOVAK, A.F. and TABER, S. (1959) 10-hydroxy-δ2-decenoic acid, an antibiotic found in royal jelly. Science 130: 452-453.Google Scholar
BONOMI, A., BONOMI, B., FORMAGGIONI, P. and QUARANTELLI, A. (2000) The use of royal jelly in feeding laying hens. Rivista di Scienza dell'Alimentazione 29: 339-352.Google Scholar
BOSELLI, E., CABONI, M.F., SABATINI, A.G., MARCAZZAN, G.L. and LERCKER, G. (2003) Determination and changes of free amino acids in royal jelly during storage. Apidologie 34: 129-137.Google Scholar
CHEN, D., LIU, F., WAN, J.-B., LAI, C.Q. and SHEN, L.R. (2017) Effect of major royal jelly proteins on spatial memory in aged rats: Metabolomics analysis in urine. Journal of Agricultural and food Chemistry 65: 3151-3159.Google Scholar
EL-TARABANY, M.S. (2017) Effect of Royal Jelly on behavioural patterns, feather quality, egg quality and some haematological parameters in laying hens at the late stage of production. Journal of Animal Physiology and Animal Nutrition 102: e599-e606.Google Scholar
ENFEKSIYONU, S.O.İ.İ.S. and ARı, Ö. (2014) Antibacterial effect of royal jelly for preservation of implant-related spinal infection in rat. Turkish Neurosurgery 24: 249-252.Google Scholar
FUJI, A., KOBAYASHI, S. and KUBOYAMA, N. (1990) Augmantation of wound healing by royal jelly in streptozocindiabetic rats. Japanese Journal of Pharmacology 53: 331-337.Google Scholar
FUJIWARA, S., IMAI, J., FUJIWARA, M., YAESHIMA, T., KAWASHIMA, T. and KOBAYASHI, K. (1990) A potent antibacterial protein in royal jelly. Purification and determination of the primary structure of royalisin. Journal of Biological Chemistry 265: 11333-11337.Google Scholar
GUNALDI, O., DAGLIOGLU, Y.K., TUGCU, B., KIZILYILDIRIM, S., POSTALCI, L., OFLUOGLU, E. and KOKSAL, F. (2014) Antibacterial effect of royal jelly for preservation of implant-related spinal infection in rat. Turkish Neurosurgery 24: 249-252.Google Scholar
GUO, H., SAIGA, A., SATO, M., MIYAZAWA, I., SHIBATA, M., TAKAHATA, Y. and MORIMATSU, F. (2007) Royal jelly supplementation improves lipoprotein metabolism in humans. Journal of Nutritional Science and Vitaminology 53: 345-348.Google Scholar
HASHEMIPOUR, M.A., TAVAKOLINEGHAD, Z., ARABZADEH, S., IRANMANESH, Z. and NASSAB, S. (2014) Antiviral activities of honey, royal jelly, and acyclovir against hsv-1. Wounds: A Compendium of Clinical Research and Practice 26: 47-54.Google Scholar
JAFARI, Y., HASHEMI, S.R. and AKHLAGHI, A. (2013) Effect of in ovo injection of royal jelly on post-hatch growth performance and immune response in broiler chickens challenged with Newcastle disease Virus. Iranian Journal of Applied Animal Science 3: 201-206.Google Scholar
JALALI, A.S., NAJAFI, G., HOSSEINCHI, M. and SEDIGHNIA, A. (2015) Royal jelly alleviates sperm toxicity and improves in vitro fertilization outcome in stanozolol-treated mice. Iranian Journal of Reproductive Medicine 13: 15-22.Google Scholar
JAMNIK, P., GORANOVIČ, D. and RASPOR, P. (2007) Antioxidative action of royal jelly in the yeast cell. Experimental Gerontology 42: 594-600.Google Scholar
JUSTIN, O.S., MIZRAHI, A. and LENSKY, Y. (1996) Chemical composition and application, in: Bee products. London, UK: Plenum 2: 15-26.Google Scholar
KAMAKURA, M., MITANI, N., FUKUDA, T. and FUKUSHIMA, M. (2001) Antifatigue effect of fresh royal jelly in mice. Journal of Nutritional Science and Vitaminology 47: 394-401.Google Scholar
KANBUR, M., ERASLAN, G., BEYAZ, L., SILICI, S., LIMAN, B.C., ALTıNORDULU, Ş. and ATASEVER, A. (2009) The effects of royal jelly on liver damage induced by paracetamol in mice. Experimental and Toxicologic Pathology 61: 123-132.Google Scholar
KODAI, T., UMEBAYASHI, K., NAKATANI, T., ISHIYAMA, K. and NODA, N. (2007) Compositions of royal jelly ii. Organic acid glycosides and sterols of the royal jelly of honeybees (apis mellifera). Chemical and Pharmaceutical Bulletin 55: 1528-1531.Google Scholar
KOHNO, K., OKAMOTO, I., SANO, O., ARAI, N., IWAKI, K., IKEDA, M. and KURIMOTO, M. (2004) Royal jelly inhibits the production of proinflammatory cytokines by activated macrophages. Bioscience, Biotechnology, and Biochemistry 68: 138-145.Google Scholar
KRYLOV, V. and SOKOLSKII, C. (2000) Royal jelly (in Russian). Agroprompoligrafist Krasnodar; 214 pp.Google Scholar
KURKURE, N., KOGNOLE, S., PAWAR, S., GANORKAR, A., BHANDARKAR, A., INGLE, V. and KALOREY, D. (2000) Effect of royal jelly as immunonomodulator in chicks. Journal of Immunology & Immunopathology 2: 84-87.Google Scholar
MAHMOUD, F.A. (2016) Impact of Chinese royal jelly on performance, behaviour and some blood parameters in broilers reared under high stocking density. Asian Journal of Animal and Veterinary Advances 11: 620-628.Google Scholar
MAJTAN, J., KOVÁČOVÁ, E., BÍLIKOVÁ, K. and ŠIMÚTH, J. (2006) The immunostimulatory effect of the recombinant apalbumin 1-major honeybee royal jelly protein-on tnfα release. International Immunopharmacology 6: 269-278.Google Scholar
MOGHADDAM, A., BORJI, M. and KOMAZANI, D. (2014) Hatchability rate and embryonic growth of broiler chicks following in ovo injection royal jelly. British Poultry Science 55: 391-397.Google Scholar
MUFARREJ, S. and EL-SARAG, M. (1997) Effects of royal jelly on the humoral antibody response and blood chemistry of chickens. Journal of Applied Animal Research 12: 41-47.Google Scholar
NAGAI, T. and INOUE, R. (2004) Preparation and the functional properties of water extract and alkaline extract of royal jelly. Food Chemistry 84: 181-186.Google Scholar
NAGAI, T., INOUE, R., SUZUKI, N. and NAGASHIMA, T. (2006) Antioxidant properties of enzymatic hydrolysates from royal jelly. Journal of Medicinal Food 9: 363-367.Google Scholar
NAKAJIMA, Y., TSURUMA, K., SHIMAZAWA, M., MISHIMA, S. and HARA, H. (2009) Comparison of bee products based on assays of antioxidant capacities. BMC Complementary and Alternative Medicine 9: 4.Google Scholar
OKAMOTO, I., TANIGUCHI, Y., KUNIKATA, T., KOHNO, K., IWAKI, K., IKEDA, M. and KURIMOTO, M. (2003) Major royal jelly protein 3 modulates immune responses in vitro and in vivo. Life Sciences 73: 2029-2045.Google Scholar
OSMAN, H. and ELGADIR, A. (2015) Effect of royal jelly on humoral antibody response, blood chemistry and performance of broiler &layer chickens. A master degree thesis. University of Khartoum for the degree of Master of Science (Zoology).Google Scholar
PAVEL, C.I., MĂRGHITAŞ, L.A., BOBIŞ, O., DEZMIREAN, D.S., ŞAPCALIU, A., RADOI, I. and MĂDAŞ, M.N. (2011) Biological activities of royal jelly-review. Scientific Papers Animal Science and Biotechnologies 44: 108-118.Google Scholar
PREMRATANACHAI, P. and CHANCHAO, C. (2014) Review of the anticancer activities of bee products. Asian Pacific Journal of Tropical Biomedicine 4: 337-344.Google Scholar
RAMADAN, M.F. and AL-GHAMDI, A. (2012) Bioactive compounds and health-promoting properties of royal jelly: A review. Journal of Functional Foods 4: 39-52.Google Scholar
SABATINI, A.G., MARCAZZAN, G.L., CABONI, M.F., BOGDANOV, S. and ALMEIDA-MURADIAN, L. (2009) Quality and standardisation of royal jelly. Journal of ApiProduct and ApiMedical Science 1: 1-6.Google Scholar
SANTOS, K.S., DOS SANTOS, L.D., MENDES, M.A., DE SOUZA, B.M., MALASPINA, O. and PALMA, M.S. (2005) Profiling the proteome complement of the secretion from hypopharyngeal gland of africanized nurse-honeybees (apis mellifera l.). Insect Biochemistry and Molecular Biology 35: 85-91.Google Scholar
SERRA BONVEHI, J. and ESCOLA JORDA, R. (1991) Study of the microbiological quality and bacteriostatic activity of queen food (royal jelly): Effect of organic acids. Deutsche Lebensmittel-Rundschau 87: 256-529.Google Scholar
SEVEN, I., ŞIMŞEK, U.G., GOKÇE, Z., SEVEN, P.T., ARSLAN, A. and YILMAZ, O. (2014) The effects of royal jelly on performance and fatty acid profiles of different tissues in quail (coturnix coturnix japonica) reared under high stocking density. Turkish Journal of Veterinary & Animal Sciences 38: 271-277.Google Scholar
SEVEN, P.T., ARSLAN, A.S., OZCELIK, M., SIMSEK, U.G. and SEVEN, I. (2016) Effects of propolis and royal jelly dietary supplementation on performance, egg characteristics, lipid peroxidation, antioxidant enzyme activity and mineral levels in Japanese quail. European Poultry Science 80: DOI: 10.1399/eps.2016.138.Google Scholar
SIAVASH, M., SHOKRI, S., HAGHIGHI, S., MOHAMMADI, M., SHAHTALEBI, M.A. and FARAJZADEHGAN, Z. (2011) The efficacy of topical royal jelly on diabetic foot ulcers healing: A case series. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences 16: 904-909.Google Scholar
STEEL, R.G.D. and TORRIE, J.H. (1980) Principles and procedures of statistics. A Biometrical approach. 2nd ed. .New York, USA: McGraw-Hill Book Company; pp. 112-121.Google Scholar
STOCKER, A. (2003) Isolation and characterisation of substances from Royal Jelly. PhD Thesis; Université d'Orléans; Orléans (France).Google Scholar
SUZUKI, K.M., ISOHAMA, Y., MARUYAMA, H., YAMADA, Y., NARITA, Y., OHTA, S., ARAKI, Y., MIYATA, T. and MISHIMA, S. (2008) Estrogenic activities of fatty acids and a sterol isolated from royal jelly. Evidence-Based Complementary and Alternative Medicine 5: 295-302.Google Scholar
TAKENAKA, T., YATSUNAMI, K. and ECHIGO, T. (1986) Changes in quality of royal jelly during storage. Nippon Shokuhin Kogyo Gakkaishi 33: 1-7.Google Scholar
TOKUNAGA, K., SUZUKI, K.-M., YOSHIDA, C., MARUYAMA, H., FUTAMURA, Y., ARAKI, Y. and MISHIMA, S. (2004) Antihypertensive mechanism of royal jelly treated with protease in spontaneously hypertensive rats. Journal of the Japanese Society for Food Science and Technology (Japan) 51: 34-37.Google Scholar
TOWNSEND, G.F., MORGAN, J.F., TOLNAI, S., HAZLETT, B., MORTON, H.J. and SHUEL, R.W. (1960) Studies on the in vitro antitumor activity of fatty acids. I. 10-hydroxy-2-decenoic acid from royal jelly. Cancer Research 20: 503-510.Google Scholar
TSENG, J.M., HUANG, J.R., HUANG, H.C., TZEN, J.T., CHOU, W.M. and PENG, C.C. (2011) Facilitative production of an antimicrobial peptide royalisin and its antibody via an artificial oil-body system. Biotechnology Progress 27: 153-161.Google Scholar
VEZETEU, T.V., BOBIŞ, O., MORITZ, R.F. and BUTTSTEDT, A. (2017) Food to some, poison to others-honeybee royal jelly and its growth inhibiting effect on European foulbrood bacteria. Microbiology Open 6 (1): e00397.Google Scholar
VIUDA-MARTOS, M., RUIZ-NAVAJAS, Y., FERNANDEZ-LOPEZ, J. and PEREZ-ALVAREZ, J.A. (2008) Functional properties of honey, propolis, and royal jelly. Journal of Food Science 73: R117-124.Google Scholar
VUCEVIC, D., MELLIOU, E., VASILIJIC, S., GASIC, S., IVANOVSKI, P., CHINOU, I. and COLIC, M. (2007) Fatty acids isolated from royal jelly modulate dendritic cell-mediated immune response in vitro. International Immunopharmacology 7: 1211-1220.Google Scholar
YONESHIRO, T., KAEDE, R., NAGAYA, K., AOYAMA, J., SAITO, M., OKAMATSU-OGURA, Y., KIMURA, K. and TERAO, A. (2017) Royal jelly ameliorates diet-induced obesity and glucose intolerance by promoting brown adipose tissue thermogenesis in mice. Obesity Research and Clinical Practice 12 (1): 127-137, doi.org/10.1016/j.orcp.2016.12.006.Google Scholar