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Jack bean (Canavalia ensifomis L. DC) in poultry diets: antinutritional factors and detoxification studies – a review

Published online by Cambridge University Press:  18 September 2007

R. Belmar ,
R. Nava-Montero ,
C. Sandoval-Castro  and
J.M. McNab
R. Belmar
Affiliation:
Universidad Autónoma de Yucatán, Apartado Postale 4–116, Itzimná, Mérida, Yucatán, Mexico
R. Nava-Montero
Affiliation:
Crupy, Universidad Autónoma Chapingo, Apartado Postale 50, Cordmex, Yucatán, Mexico
C. Sandoval-Castro
Affiliation:
Universidad Autónoma de Yucatán, Apartado Postale 4–116, Itzimná, Mérida, Yucatán, Mexico
J.M. McNab
Affiliation:
Roslin Institute (Edinburgh), Roslin, Midlothian EH25 9PS, UK
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Abstract

A review is given on the effects of the inclusion of Jack beans (Canavalia ensifomis L. DC) in poultry diets. Their use is restricted by the presence of a number of antinutritional factors which affect performance when consumed by poultry. The principals of these are identified as concanavalin-A (a lectin), canavanine and canaline (so-called non-protein amino acids), urease and saponins. The mechanisms of their toxicity and the rationale behind the methods that have been used to detoxify Jack beans are described. These mainly involve heat processing, but other approaches such as ensiling, fermentation and addition of chemicals have been applied. It is concluded that, although substantial improvements in nutritional value can result from a number of such treatments, processed Jack beans still contain a residual toxic component which results in depressions in growth rate, food intake and food conversion efficiency when they are included in poultry diets.

Keywords

Antinutritional factorsbroilersJack beansprocessingtoxicity
Type
Research Article
Information
World's Poultry Science Journal , Volume 55 , Issue 1 , March 1999 , pp. 37 - 59
Copyright
Copyright © Cambridge University Press 1999

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References

Acamovic, T. (1987) Analysis and nutritional evaluation for young chicks of some toxic factors in three novel legumes. PhD Thesis, University of EdinburghGoogle Scholar
Acamovic, T. and D'mello, J.P.F. (1990) HPLC analysis of canavanine and canaline in Canavalia ensiformis and in excreta and serum of chicks. Journal of the Science of Food and Agriculture 50: 63–77Google Scholar
Aguirre, J., Mora, M. and Carabano, J.M. (1989) Crecimiento de pollos de engorde recibiendo harina de granos de Canavalia ensiformis extrudada en la ración. Inform Anual, Universidad Central de Venezuela, Facultad de Agronom'a, Instituto de Producción Animal, Universidad Central de Venezuela, Maracay, Venezuela, 1987, pp. 49–50Google Scholar
Allende, C. and Allende, J. (1964) Purification and substrate specificity of arginyl-ribonucleic acid synthetase from rat liver. Journal of Biological Chemistry 239: 1102–1106CrossRefGoogle ScholarPubMed
Arora, S.K. (1995) Composition of legumes grains. In: Tropical Legumes in Animal Nutrition (D'Mello, J.P.F. and Devendra, C., Eds), CAB International, pp. 67–93Google Scholar
Attias, J., Shlesinger, M. and Shlesinger, S. (1969) The effect of amino acid analogues on alkaline phosphatase formation in Escherichia coli K-12. Journal of Biological Chemistry 244: 3810–3817CrossRefGoogle ScholarPubMed
Babar, V.S., Chavan, J.K. and Kadam, S.S. (1988) Effects of heat treatments and germination on trypsin inhibitor activity and polyphenols in Jack bean (Canavalia ensiformis L. DC). Plant Foods for Human Nutrition 38: 319–324CrossRefGoogle ScholarPubMed
Baich, A. and Nekola, M. (1988) Accumulation of ornithine by chick retinal pigment epithelium cells in culture. Biochemica et Biophysica Acta 970: 19–21CrossRefGoogle ScholarPubMed
Bell, E.A. (1958) Canavanine and related compounds in leguminosae. Biochemical Journal 70: 617–619Google Scholar
Bell, E.A. (1960) Canavanine in the leguminosae. Biochemical Journal 75: 618–620Google Scholar
Bell, E.A., Lackey, J.A. and Polhill, R.M. (1978) Systematic significance of canavanine in the Papillonoidae (Faboideae). Biochemical Systematics and Ecology 6: 201–212Google Scholar
Belmar, R. and Morris, T.R. (1994a) Effects of raw and treated jack beans (Canavalia ensiformis) and of canavanine on the short-term feed intake of chicks and pigs. Journal of Agricultural Science, Cambridge 123: 407–414CrossRefGoogle Scholar
Belmar, R. and Morris, T.R. (1994b) Effects of the inclusion of treated jack beans (Canavalia ensiformis) and the amino acid canavanine in chick diets. Journal of Agricultural Science, Cambridge 123: 393–405Google Scholar
Boorman, K.N. and Lewis, D. (1971) Protein metabolism. In: Physiology and Biochemistry of the Domestic Fowl (Bell, D.J. and Freeman, B.M., Eds), Academic Press, London, pp. 339–372Google Scholar
Bressani, R. and Sosa, J.L. (1990) Effects of processing on the nutritive value of Canavalia Jack beans (Canavalia ensiformis (L)). Plant Foods for Human Nutrition 40: 207–214CrossRefGoogle Scholar
Bressani, R., Braham, J.E. and Elias, L.G. (1983) Effects on nutritional effects of food legumes from chemical changes through processing and storage. In: Chemistry and World Food Supplies: The New Frontiers Chemrawn II (Shemilt, L.W., Ed.), Pergamon Press, Oxford, pp. 403–491Google Scholar
Bressani, R., Gomez, R.B., Garcia, A. and Elias, L.G. (1987) Chemical composition, amino acid content and protein quality of Canavalia spp. seed. Journal of the Science of Food and Agriculture 40: 17–23CrossRefGoogle Scholar
Carlini, C.R. (1988) Estructura, mecanismo de accion y aplicaciones potenciales de la canatoxina, una hemilectina toxica aislada de las semillas de Cannvalia ensiformis. In: Canavalia ensiformis (L.) DC Produción, Procesamientoy Utilización en Alimentación Animal (Vargas, R.E, León, A. and Escobar, A., Eds). Compilación de los trabajos presentados en el primer Seminario-Taller sobre Cannvalia ensiformis celebrado en Maracay, Venezuela, del 25 a1 28 de junio de 1991, Fundación Polar, Venezuela, pp. 169–178Google Scholar
Carlini, C.R. (1993) Estructura, necesidades de acción y aplicationes potenciales de la canatoxina, una hemilectina toxica aislada de la semilla de Canavalia ensiformis. In: Canavalia ensiformis (L.) DC Producción, Procesamiento y utilización en Alimentación Animal (Vargas, R.E, León, A. and Escobar, A., Eds). Compilación de los trabajos presentados en el primer Seminario-Taller sobre Canavalia ensiformis celebrado en Maracay, Venezuela, del 25 a1 28 de junio de 1991, Fundación Polar, Venezuela, pp. 169–178Google Scholar
Carlini, C.R. and Guimaraes, J.A. (1981) Isolation and characterization of a toxic protein from Canavalia ensiformis (jack bean) seeds, distinct from concanavalin-A. Toxicon 19: 667–675CrossRefGoogle ScholarPubMed
Cheeke, P.R. (1971) Nutritional and physiological implications of saponins: a review. Canadian Journal of Animal Science 51: 621–623CrossRefGoogle Scholar
Cheeke, P.R. (1976) Nutritional and physiological properties of saponins. Nutrition Reports International 13: 315–324Google Scholar
Crine, P. and Lemieux, E. (1982) Incorporation of canavanine into rats pars intermedia proteins inhibits the maturation of pro-opiomelanocortin, the common precursor to adrenocorticotrophin and β-lipotropin. Journal of Biological Chemistry 257: 832–838CrossRefGoogle ScholarPubMed
Dennison, C., Stead, U. and Quicke, G.V. (1971) A nonhaemagglutinating toxic factor from the Jack bean (Canavalia ensiformis). Agroplanta 3: 27–30Google Scholar
Dixon, N.E., Riddles, P.W., Gazzola, C., Blakeley, R.L. and Zerner, B. (1980) Jack bean urease (EC 3.5.1.5.) on the mechanism of action of urease and urea, formamide, acetamide, n-methyl urea and your related compounds. Canadian Journal of Biochemistry 58: 1534–1535CrossRefGoogle Scholar
Dixon, R. M., Escobar, A., Montilla, J., Viera, J., Carabaro, J., Mora, M., Risso, J., Parra, R. and Preston, T.R. (1983) Canavalia ensiformis: a legume for the tropics. In: Recent.Advances in Nutrition in Australia (Farrell, D.J. and Vohra, P., Eds), University of New England Publishing Unit, Armidale, pp. 129–140Google Scholar
D'mello, J.P.F. (1982) Toxic factors in some tropical legumes. World Review of Animal Production 18: 41–46Google Scholar
D'mello, J.P.F. (1989)Toxic amino acids. In: Anti-Nutritional Factors, Potentially Toxic Substances in Plants. Aspects of Applied Biology, Volume 19 (D'Mello, J.P.F., Duffus, C.M. and Duffus, J.H., Eds), Association of Applied Biologists, Wellesbourne, Warwick, pp. 29–50Google Scholar
D'mello, J.P.F.and Walker, A.G. (1991) Detoxification of jack beans (Canavalia ensiformis):studies with young chicks. Animal Feed Science and Technology 33: 117–127CrossRefGoogle Scholar
D'mello, J.P.F., Acamovic, T. and Walker, A.G. (1985) Nutritive value of jack beans (Canavalia ensiformis (L.) DC) for young chicks. Tropical Agriculture (Trinidad) 62: 145–150Google Scholar
D'mello, J.P.F., Walker, A.G. and Acamovic, T. (1988) Concentration of total amino acids including canavanine during germination of Canavalia ensiformis (L) DC. Tropical Agriculture (Trinidad) 65: 376–378Google Scholar
D'mello, J.P.F., Acamovic, T. and Walker, A.G. (1989) Nutritive value of jack beans (Canavalia ensiformis (L.) DC) for young chicks: effects of amino acid supplementation. Tropical Agriculture (Trinidad) 66: 201–205Google Scholar
D'mello, J.P.F., Walker, A.G. and Noble, E. (1990) Effects of dietary supplements on the nutritive value of jack beans (Canavalia ensiformis) for the young chick. British Poultry Science 31: 759–768CrossRefGoogle Scholar
Duke, J.A. (1981) Handbook of Leguemes of WOrld Economic Importance, Plenum Press, London, pp. 39–40CrossRefGoogle Scholar
Eb, B.F and Belmer, R. (1987) Efecto del Hervido-Agitado de Canavalia ensiformis sobre el comportamiento de pollo de engorda. In: Memorias: II Reunion sobre la produccion y utilizacion del grano de Canavalio ensiformis en sistemas pecuarios de Yucatán, F.M.V.Z.-U.A.D.Y., Yucatán, MéxicoGoogle Scholar
Ellis, N. and Belmar, R. (1985) La composición qu'mica del grano de (Canavalia ensiformis): su valor nutritivo y sus factores tóxicos. In: Memorias: I Reunion sobre la produccion y utilizacion del grano de Canavalia ensiformis en sistemas pecuarios de Yucatán, F.M.V.Z.-U.A.D.Y., Yucatán, MéxicoGoogle Scholar
Ellis, N., Belmar, R. and Laviada, E. (1985) Utilizacion del grano de Canavalia ensiformis en dietas para aves. In: Memorias: I Reunion sobre la producciony utilizacion del grano de Canavalia ensiformis en sistemas pecuarios de Yucatón F.M.V.Z.-U.A.D.Y., Yucatán, MéxicoGoogle Scholar
Escobar, A., Viera, J., Dixon, R., Mora, M. and Parra, R. (1983) Canavalia ensiformis: Una leguminosa para la producción animal en los trópicos. Informe Anual, Facultad de Ciencias, Uniuersidad Central de Venezuela, Universidad Central de Venezuela, Maracay, Venezuela, pp. 131–164Google Scholar
Forbes, M. (1986) The Voluntary Food Intake of Farm Animals, Butterworths, London, pp. 203–224Google Scholar
Glimp, H.A. and Tillman, A.D. (1964) Effects of Jack bean urease injections and chlortetracycline on rate of gain and feed efficiency in swine. Journal of Animal Science 23: 963Google Scholar
Gohl, B. (1981) Tropical feed. Feed information summaries and values. In: Animal Production and Health Series 12, FAO, Rome, pp. 143–144Google Scholar
Gomez-Sotillo, A., Carmona, A. and Seidi, S. (1993) Fractionation of Canavalia ensifomis proteins. Distribution of the proteic antinutritional factors. In: Recent Advances of Research in Antinutritional Factors in Legume Seeds: Proceedings of the Second lnternafional Workshop on Antinutritional Factors (ANFS) in Legume Seeds (van der Poel, A.F.B. and Saini, H.S., Eds), EAAP Publication No 70, Wageningen, The Netherlands, pp. 235–239Google Scholar
Gulati, A.K., Zalewski, A.A., Sharma, B.K. and Sohal, G.S. (1986) A comparison of lectin binding in rat and human peripheral nerve. Journal of Histochemistry and Cytochemistry 34: 1487–1493CrossRefGoogle ScholarPubMed
Hague, D.R. (1975) Studies of storage proteins of higher plants. Concanavalin-A from three species of the genus Canavalia. Plant Physiology 55: 636–642CrossRefGoogle ScholarPubMed
Hegarty, M.P. (1978) Toxic amino acids of plant origin. In: Effects of Poisonous Plants on Livestock (Keeler, R.F., Kampen, K.R.V., James, L.F., Eds), Academic Press, New York, pp. 575–585CrossRefGoogle Scholar
Herman, E.M. and Shannon, L.M. (1984) Immunocytochemical localization of concanavalin-A in developing Jack bean cotyledons. Planta 161: 97–104CrossRefGoogle ScholarPubMed
Herman, E.M., Shannon, L.M. and Chrispeels, M.J. (1985) Concanavalin-A is synthesized as glycoprotein precursor. Planta 165: 23–29CrossRefGoogle ScholarPubMed
Herrera, F. G. (1983) Effect of planting density on the seed yield of Canavalia ensiformis. Tropical Animal Production 8: 153–156Google Scholar
Herrera, F., GutiÉrrez, M., Cupul, S., Ferreiro, M., CarabaÑo, J. M. and Montilla, J.J. (1981) Efecto de la incorporación de semilla de Canavalia ensiformis a1 10y 20% sobre el comportamiento de gallinas de postura. Producción Animal Tropical 6: 408Google Scholar
Hoil, R.I. and Chel, G.I. (1987) Modificacion del valor nutritive del grano de Canavalia ensiformis mediante germinación. In: Memorias: II Reunion sobre la produccion y utilizacion del grano de Canavalia ensiformis en sistemas pecuarios de Yucatón, F.M.V.Z.-U.A.D.Y., Yucatón, MéxicoGoogle Scholar
Horowitz, N.H. and Asrab, A.M. (1948) Growth inhibition of neurospora by canavanine and its reversal. Journal of Biological Chemistry 174: 371–378Google Scholar
Instituto Nacional De Investigaciones Agricolas (Inia) (1983) Resumen de Investigaciones Forrajeras 1983, Secretaria de Agricultura y Recursos Hidráulicos, Gobierno de México, México, p. 7Google Scholar
Jaffe, W.G. (1980) Hemagglutinins (lectins). In: Toxic Constituents of Plant Foodstuffs (Liener, I.E., Ed.), Academic Press, New York, pp. 73–98Google Scholar
Jayne-Williams, D.J. (1973) Influence of dietary Jack bean (Canavalia ensiformis) and of concanavalin-A on the growth of conventional and gnotobiotic Japanese quail (Cofurnix japonica). Nature, New Biology 243: 150Google Scholar
Jayne-Williams, D.J. (1978) The significance of the intestinal microflora in relation to the oral toxicity of raw navy beans and Jack beans for Japanese quail. In: Plant Proteins (Norton, G., Ed.), Butterworths, London, pp. 141–152Google Scholar
Johnson, L.T., Gee, J.M., Price, K., Curl, C. and Fenwick, G.R. (1986) Influence of saponins in gut permeability and active nutrient transport in vitro. Journal of Nutrition 116: 2270–2272CrossRefGoogle ScholarPubMed
Kay, D.E. (1979) Food legumes. T.P.I. Crop and Product Digest 3, Tropical Products Institute, London, pp. 197–204Google Scholar
Kessler, M., Belmar, R. and Ellis, N. (1990) Effects of autoclaving on the nutritive value of the seeds of Canavalia ensiformis (jackbean) for chicks. Tropical Agriculture (Trinidad) 67: 16–20Google Scholar
Laviada, A.E. (1983) Estudios preliminares del efecto de diferentes tratamientos destoxificantes sobre la semilla de Canavalia ensiformis y su utilización en la alimentación de las aves. MSc Thesis, F.M.V.Z-U.A.D.Y.Google Scholar
Lee, D.J.W. (1977) Urease activity in the digestive tract of the chick and its role in the utilisation of urea as a source of non amino nitrogen. British Poultry Science, 18: 449–458CrossRefGoogle ScholarPubMed
leÓn, A., Reina, Y. and Vargas, R. (1986) Determinacion de la energia metabolizable de 10s granos de Canavalia ensiformis crudos o extruidos. Informe Anual, Facultad de Agronomia, Universidad Central de Venezuela, Universidad Central de Venezuela, Maracay, Venezuela, pp. 43–44Google Scholar
LeÓn, A., Vargas, R.E., Michelangeli, C., CarabaÑo, J. M., Risso, J. and Montilla, J.J. (1993) Valor nutricional de los granos de Canavalia ensiformis en dietas para avesy cerdos. In: Canavalia ensiformis (L.) DC Producción, Procesamientoy Utilización en Alimentmión Animal (Vargas, R.E, León, A. and Escobar, A., Eds). Compilación de los trabajos presentados en el primer Seminario-Taller sobre Canavalia ensiformis celebrado en Maracay, Venezuela, del 25 a1 28 de junio de 1991, Fundación Polar, Venezuela, pp. 213–227Google Scholar
LeÓn, A., Angulo, Y., Picard, M., CarrÉ, B., Deurouet, L. and Harscoat, J.P. (1989a) Proximate and amino acid composition of seed of Canavalia ensiformis. Toxicity of the kernel fraction for chicks. Annales de Zootechnie 38: 209–218CrossRefGoogle Scholar
LeÓn, A., CarrÉ, B., Larbier, M., Lim, F., Ladjali, T. and Picard, M. (1990) Amino acids and starch digestibility and true metabolizable energy content of raw and extruded jackbeans (Canavalia ensiformis) in adult cockerels. Annuls de Zootechnie 39: 53–61Google Scholar
LeÓn, A.M., Caffin, J.P., Plassart, M. and Picard, M.L. (1991) Effect of concanavalin A from jackbean seeds on short-term food intake regulation in chicks and laying hens. Animal Feed Science and Technology 32: 297–311CrossRefGoogle Scholar
LeÓn, T., Reina, Y. and Vargas, R. (1987a) Evaluación nutricional de cuatro cultivares de Canavalia ensiformis cruda en raciones para pollos de engorde. Informe Anual, Facultad de Agronomia, Universidad Central de Venezuela, Universidad Central de Venezuela, Maracay, Venezuela, pp. 47–48Google Scholar
leÓn, T., Reina, Y. and Vargas, R. (1987b) Respuesta en pollos de engorde a harinas de Canavalia ensiformis de diferentes cultivares tratados en autoclave y remojo. Informe Anual, Facultad de Agronomia, Universidad Central de Venezuela, Universidad Central de Venezuela, Maracay, Venezuela, pp. 51–52Google Scholar
leÓn, T., Reina, Y., Montilla, J., Ramis, C. and Viera, J. (1989b) Respuesta en pollos de engorde a harinas de Canavalia ensiformis de diferentes cultivares tratados en autoclave y remojo. Informe Anual, Facultad de Agronomia, Universidad Centrul de Venezuela, Universidad Central de Venezuela, Maracay, Venezuela, pp. 51–52Google Scholar
Liener, I.E. (1974) Phytohemagglutinins: their nutritional significance. Journal of Agriculture and Food Chemistry 22: 17–22CrossRefGoogle ScholarPubMed
Liener, I.E. (1979) Phytohemagglutinins. In: Herbivores: Their Interaction With Secondary Plant Metabolites (Rosenthal, G.A., Ed.), Academic Press, New York, pp. 567–597Google Scholar
Liener, I.E. (1980) Heat-labile antinutritional factors. In: Advances in Legume Science (Summerfield, R.J. and Bunting, A.H., Eds), Royal Botanical Gardens, Kew, London, pp. 157–170Google Scholar
Liener, I.E. (1981) The nutritional significance of the plant lectins. In: Antinutrients and Natural Toxicants in Foods (Ory, R.L., Ed.), Food & Nutrition Press, Westport, Connecticut, pp. 143–157Google Scholar
Liener, I.E. (1983a) Toxic constituents in legumes. In: Chemistry and Biochemistry of Legumes (Arora, S.K., Ed.), Edward Arnold, London, pp. 217–257Google Scholar
Liener, I.E. (1983b) Removal by processing of naturally occurring toxicants and antinutrients. In: Chemistry and World Food Supplies: The New Frontiers Chemrawn II (Shemilt, L.W., Ed.), Pergamon Press, Oxford, pp. 143–161Google Scholar
Liener, I.E. and Kakade, M.L. (1980) Protease inhibitors. In: Toxic Constituents of Plants Foodstuffs (Liener, I.E., Ed.), Academic Press, New York, pp. 7–71Google Scholar
Lopez, L., Vargas, A. and Segura, J. (1989) Utilizacion de la canavalia (Canavalia ensiformis) en la dieta de gallinas de postura. Informe Annual, Facultad de Medicina Veterinaria y Zootecnia, U.A.D.Y., Mérida, Yucatán, México, pp. 61–63Google Scholar
Melcion, J.P., Michelangeli, C. and Picard, M. (1994) Evaluation of the effect of extrusion cooking of jackbean (Canavalia ensiformis L.) seed on short-term feed intake in chicks. Animal Feed Science and Technology 46 197–213CrossRefGoogle Scholar
Merck, (1989) The Merck Index: an Encyclopedia of Chemicals, Drugs and Biologicals (Budavari, S., O'Neal, M.J., Smith, A, Heckelman, P.E., Eds), Merck & Co., Rahway, NJ, USA, p. 263Google Scholar
Michelangeli, C. and Vargas, R.E. (1994) L-Canavanine influences feed intake, plasma basic amino acid concentrations and kidney arginase activity in chicks. Journal of Nutrition 124: 1081–1087CrossRefGoogle ScholarPubMed
Milner, J.A. (1985) Metabolic aberrations associated with arginine deficiency. Journal of Nutrition 115: 516–523Google Scholar
Molina, M.R. and Bressani, R. (1975) Protein starch extraction and nutritive value of Jack bean and Jack bean protein isolate. In: Nutritional Aspects of Common Beans and Other Legume Seeds as Animal and Human Foods, Archivos Latinoamericanos de Nutricion (Jaffe, W.G., Dutra de Oliveira, J.E., Eds), Caracas, Venezuela, pp. 153–163Google Scholar
Molina, M.R., Argueta, C.E. and Bressani, R. (1974) Extraction of nitrogenous constituents from the Jack bean (Canavalia ensiformis). Journal of Agriculture and Food Chemistry 22: 309–312Google Scholar
Molina, M.R., Bressani, R. and Elias, L.G. (1977) Non conventional legume grains as protein sources. Food Technology 31: 188–190Google Scholar
Montilla, J.J., Ferreiro, M., Cupul, S., Gutierrez, M. and Preston, T.R. (1981) Observaciones preliminares sobre el efecto del ensilaje y el tratamiento termico del grano de Canavalia ensiformis en dietas para aves. Producción Animal Tropical 6: 408–409Google Scholar
National Academy of Sciences (1979) Tropical Legumes: Resources for the Future, National Academy of Sciences, Washington DC, pp. 54–59Google Scholar
Neurath, A.R., Wiener, F.P., Rubin, B.A. and Hartzeu, R.W. (1970) Inhibition of adenovirus replication by canavanine. Biochemical and Biophysical Research Communications 41: 1509–1517Google Scholar
Novus (1994) Raw Material Compendium. A Compilation of Worldwide Data Sources. 2nd edn, NOVUS, Brusse1sGoogle Scholar
Ologhobo, A.D., Apata, D.F. and Oyejide, A. (1993) Utilisation of raw jackbean (Canavalia ensiformis) and jackbean fractions in diets for broilers chicks. British Poultry Science 34: 323–337CrossRefGoogle Scholar
Perez, M.M. (1984)Canavalia ensiformis en la alimentación de pollos de engorda. EQ Thesis, F.M.V.Z- U.A.D.Y.Google Scholar
Price, K.R., Curl, C.L. and Fenwick, G.R. (1986) The saponin content and sapogenol composition of the seed of 13 varieties of legume. Journal of the Science of Food and Agriculture 37: 1185–1191CrossRefGoogle Scholar
Pusztai, A. (1989) Biological effects of dietary lectins. In: Recent Advances of Research in Anti-Nutritional Factors in Legume Seeds. Proceedings of the First International Workshop on Anti-Nutritional Factors (ANFs) in Legume Seeds (Huisman, J., van der Poel, T.F.B. and Liener, I.E., Eds), Pudoc, Wageningen, The Netherlands pp. 17–29Google Scholar
Rahiala, E. (1973) Canaline. Characterization of enzyme pyridoxal phosphate complex. Acta Chemica Scandinavica 27: 3861–3867CrossRefGoogle ScholarPubMed
Ramirez, A.L., Armendariz, Y.I. and Kessler, C.D.J., (1987) Estrategias en el manejo agronómico del frijol Canavalia ensiformis. In: Memorias: II Reunion sobre In produccion y utilizacion del grano de Canavalia ensiformis en sisternus pecuarios de Yucatón F.M.V.Z-U.A.D.Y., Yucatán, MéxicoGoogle Scholar
Rao, C.N. and Rao, B.S.N. (1978) Influence of starches from different sources on protein utilization in rats. British Journal of Nutrition 40: 1–8CrossRefGoogle Scholar
Raychaudhuri, M. and Singh, M. (1986) A concanavalin-A like lectin in the developing seeds of Canavalia, ensiformis. Phytochemistry 25: 793–797CrossRefGoogle Scholar
Reina, Y., LeÓn, T., Montilla, J., Vierma, C., Viera, J. and Vargas, R. (1989) Efecto del autoclavado o remojo sobre el valor nutricional de Canavalia ensiformis para pollos de engorde. Informe Anual, Facultad de Agronomia, Universidad Central de Venezuela, Universidad Central de Venezuela, Maracay, Venezuela, pp. 48–49Google Scholar
Rinderknecht, H. (1960) Chemical degradation of canavanine to canaline. Nature 186: 1047–1048CrossRefGoogle Scholar
Risso, J.F.C., CarabaÑo, J.M. and Montilla, J.J. (1982) Canavalia ensiformis una alternative en el components proteico de las raciones para monogástricos. In: Memorias seminario sobre el Uso de Leguminosas Tropicales en la Alimentacion Animal XXXII Reunion Anual de la Asouac, Universidad Simón Bolivar, VenezuelaGoogle Scholar
Rivera, L.J. (1987) La utilización del grano de Canavalia ensiformis como suplemento para rumiantes. In: Memorias II: Reunion sobre la produccion y utilizacion del grano de Canaualia ensiformis en sisternus pecuarios de Yucatán, F.M.V.Z.-U.A.D.Y., Yucatán, MéxicoGoogle Scholar
Rosenthal, G.A. (1970) Investigations of canavanine biochemistry in the Jack bean plant, Canavalia ensiformis (L) DC. Plant Physiology 46: 273–276CrossRefGoogle Scholar
Rosenthal, G.A. (1972a) Investigations of canavanine biochemistry in the Jack bean plant, Canavalia ensiformis (L) DC. Plant Physiology 50: 328–311CrossRefGoogle ScholarPubMed
Rosenthal, G.A. (1972b) amino canavanine formation from canavanine. Phytochemistry 2: 2827–2832CrossRefGoogle Scholar
Rosenthal, G.A. (1974) The interrelationship of canavanine and urease in seeds of the lotoideae. Journal of Experimental Botany 25: 609–613Google Scholar
Rosenthal, G.A. (1977a) Nitrogen allocation for L-canavanine synthesis and its relationship to chemical defence of the seed. Biochemical Systematics and Ecology 5: 219–220CrossRefGoogle Scholar
Rosenthal, G.A. (1977b) The biological effects and mode of action of L-canavanine, a structural analogue of L-arginine. Quarterly Review of Biology 52: 155–178CrossRefGoogle ScholarPubMed
Rosenthal, G.A. (1981) A mechanism of L-canaline toxicity. European Journal of Biochemistry 114: 301–304CrossRefGoogle ScholarPubMed
Rosenthal, G.A. (1982) L-canavanine metabolism in Jack bean, Canavalia ensiformis (L.) DC (Leguminosae). Plant Physiology, 69: 1066–1069Google Scholar
Rosenthal, G.A. and Bell, E.A. (1979) Naturally occurring, toxic non-protein amino acids. In: Herbivores: their Interaction with Secondary Plant Metabolites (Rosenthal, G.A., Ed.), Academic Press, New York, pp. 353–381Google Scholar
Rosenthal, G.A. and Dahlman, D.C. (1982) A cautionary note on pentacyanoaminoferrate use for determining L-canavanine occurrence in biological materials. Experientia 38: 1034–1035CrossRefGoogle Scholar
Rosenthal, G.A. and Rhodes, D. (1984) L-canavanine transport and utilization in developing Jack bean, Canavalia ensiformis (L.) DC. Plant Physiology 76: 541–544Google Scholar
Rosenthal, G.A., Berge, M.A., Bleiler, J.A. and Rudd, T.P. (1987) Aberrant canavaline protein formation and the ability to tolerate or utilize L-canavanine. Experientia 43: 558–561Google Scholar
Rosenthal, G.A., BERGE, M.A., OZINSKAS, A.J. and HUGHES, C.G. (1988) Ability of L-canavanine to support nitrogen metabolism in the Jack bean, Canavalia ensiformis (L.) DC. Journal of Agricultural and Food Chemistry 36: 1159–1163CrossRefGoogle Scholar
Rosenthal, G.A., Gulati, D.K. and Sabharval, P.S. (1975) Studies on the growth effects of the canaline urea cycle amino acids with Lemma minor L. Plant Physiology 56: 420–424CrossRefGoogle Scholar
Secab, (1990) Haba Criolla Cannvalia ensiformis (L.) DC, (Fabaceae – faboideae). Monografia No. 2. Programa de Recursos vegetates del convenio Andrés Bello (PREVECAB). Secretaria Ejecutiva del Convenio Andrés Bello, SECAB, Bogota, Colombia, pp. 177–192Google Scholar
Sharon, N. and Lis, H. (1972) Lectins: cell agglutinating and sugar specific proteins. Science 177: 949–959CrossRefGoogle ScholarPubMed
Shqueir, A.A., Brown, D.L. and Klasing, K.C. (1989) Canavanine content and toxicity of sesbania leaf meal for growing chicks. Animal Feed Science and Technology 25: 137–147Google Scholar
Smartt, J. (1985) Evolution of grain legumes II. Old and new world pulses of lesser economic importance. Experimental Agriculture 21: 1–18CrossRefGoogle Scholar
Staples, S.J. and Reithel, F.J. (1976) Evidence for an active-inactive subunit complex in jack bean urease. Archives of Biochemistry and Biophysics 174: 651–657Google Scholar
Tepal, J., Castellanos, R. and Larios, A. (1994) Detoxification of Jack beans (Canavalia ensiformis):1.Extrusion and canavanine elimination. Journal of the Science of Food and Agriculture 66: 373–379CrossRefGoogle Scholar
Thomas, D.A. and Rosenthal, G.A. (1987) Metabolism of L-[guanidino-oxy-146] canavanine in the rat. Toxicology and Applied Pharmacology 91: 406–414CrossRefGoogle ScholarPubMed
Udedibie, A.B.I., (1993) Utilización de granos de Canavalia (ensiformis y gladiata) en dietas para aves en Nigeria. In: Canavalin ensiformis (L.) DC Producción, Procesamiento y Utilización en Alimentación Animal (Vargas R.E, León A. and Escobar A., Eds), Compilación de los trabajos presentados en el primer Seminario-Taller sobre Canavalia ensiformis celebrado en Maracay, Venezuela, del 25 a1 28 de junio de 1991, Fundación Polar, Venezuela, pp. 229–240Google Scholar
Udedibie, A.B.I., Nwaiwu, J., Madubuike, EN., Nkwocha, C.O. and Imo, I.O. (1988) lackbean (Canavalin ensiformis): poison turned to good protein feed. Owerri, Nigeria, Federal University of TechnologyGoogle Scholar
Udedibie, A.B.I., Esonu, B.O., Obaii, C.N. and Durunna, C.S. (1994) Dry urea treatment urior to toasting as a method of improving the nutritive value of jackbeans (Canavalia ensiformis) for broilers. Animal Food Science and Technology 48: 335–345Google Scholar
Wong, P.P. (1980) Interactions between rhizobia and lectins of lentil pea, broad bean and Jack bean. Plant Physiology 65: 1049–1052CrossRefGoogle Scholar