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Application of egg yolk antibodies as replacement for antibiotics in poultry

Published online by Cambridge University Press:  18 March 2010

M. YEGANI
Affiliation:
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2P5, Canada
D.R. KORVER*
Affiliation:
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2P5, Canada
*
Corresponding author: [email protected]
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Abstract

The ban of sub-therapeutic antibiotic use in the European Union countries and elsewhere, and recent moves toward removal or reduced use of these compounds in other countries has put pressure on the poultry industry to look for viable alternatives. Available data suggest that specific egg yolk antibodies (EYA) have beneficial effects in prevention or treatment of bacterial and viral infections in humans and different animal species. The number of studies conducted in chickens, however, is quite low compared to other species and this may be a limiting factor in the current use of this technology in the poultry industry. The objectives of this review paper are to discuss how EYA are produced and work, to present examples of their applications in different pathological conditions in chickens, and to address challenges that this technology is currently facing.

Type
Review Article
Copyright
World's Poultry Science Association 2010

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References

ABDEL-MONEIM, A.S. and ABDEL-GAWAD, M.M.A. (2006) Genetic variations in maternal transfer and immune responsiveness to infectious bursal disease virus. Veterinary Microbiology 114: 16-24.CrossRefGoogle ScholarPubMed
AKITA, E.M. and NAKAI, S. (1992) Immunoglobulins from egg yolk: Isolation and purification. Journal of Food Science 57: 629-634.CrossRefGoogle Scholar
AMARAL, J.A., TINO DE FRANCO, M., CARNEIRO-SAMPAIO, M.M. and CARBONARE, S. (2002) Anti-enteropahtogenic Escherichia coli immunoglobulin Y isolated from eggs laid by immunized Leghorn chickens. Research in Veterinary Science 72: 229-234.CrossRefGoogle ScholarPubMed
BEDFORD, M. (2000) Removal of antibiotic growth promoters from poultry diets: implications and strategies to minimize subsequent problems. World's Poultry Science Journal 56: 347-365.CrossRefGoogle Scholar
BOX, P.G., STEDMAN, R.A. and SINGLETON, L. (1969) Newcastle disease. I. The use of egg yolk derived antibody for passive immunization of chickens. Journal of Comparative Pathology 79: 495-506.CrossRefGoogle ScholarPubMed
CARLANDER, D., KOLLBERG, H., WEJAKER, P.E. and LARSSON, A. (2000) Peroral immunotherapy with yolk antibodies for the prevention and treatment of enteric infections. Immunology Research 21: 1-6.CrossRefGoogle ScholarPubMed
CARLANDER, D., STALBERG, J. and LARSSON, A. (1999) Chicken antibodies: A clinical chemistry perspective. Upsala Journal of Medical Sciences 104: 179-189.CrossRefGoogle ScholarPubMed
CARLANDER, D., WILHELMSON, M. and LARSSON, A. (2001) Limited day to day variation of IgY levels in eggs from individual laying hens. Food and Agricultural Immunology 13: 87-92.CrossRefGoogle Scholar
CARLANDER, D., WILHELMSON, M. and LARSSON, A. (2003) Immunoglobulin Y levels in egg yolk from three chicken genotypes. Food and Agricultural Immunology 15: 35-40.CrossRefGoogle Scholar
CASADEVALL, A. and SCHARFF, M.D. (1994) Serum therapy revisited: animal models of infection and development of passive antibody therapy. Antimicrobial Agents and Chemotherapy 38: 1695-1702.CrossRefGoogle ScholarPubMed
CHANG H.M., OU-YANG, R.F., , CHEN, Y.T. and CHEN, C.C. (1999) Productivity and some properties of immunoglobulin specific against Streptococcus mutants serotype c in chicken egg yolk (IgY). Journal of Agricultural and Food Chemistry 47: 61-66.CrossRefGoogle Scholar
COATES, M.E., DAVIES, M.K. and KON, S.K. (1955) The effect of antibiotics on the intestine of the chick. British Journal of Nutrition 9: 110-119.CrossRefGoogle ScholarPubMed
COLLETT, S.R. (2004) Controlling gastrointestinal disease to improve absorptive membrane integrity and optimize digestion efficiency, in: TUCKER, L.A. & TAYLOR-PICKARD, J.A. (Eds) Interfacing Immunity, Gut Health and Performance, pp. 77-91 (Nottingham, Nottingham University Press).Google Scholar
CRAY, C. and VILLAR, D. (2008) Cross-reactivity of anti-chicken IgY antibody with immunoglobulins of exotic avian species. Veterinary Clinical Pathology 37: 328-331.CrossRefGoogle ScholarPubMed
DEMEULENAER, B. and HUYGHEBAERT, A. (2001) Isolation and Purification of Chicken Egg Yolk Immunoglobulins: A Review. Food and Agricultural Immunology 13: 275-288.CrossRefGoogle Scholar
ERHARD, M.H., SCHMIDT, P., ZINSMEISTER, P., HOFMANN, A. and MÜNSTER. U. et al., (2000) Adjuvant effects of various lipopeptides and interferon-γ on the humoral immune response of chickens. Poultry Science 79: 1264-1270.CrossRefGoogle ScholarPubMed
ETERRADOSSI, N., TOQUIN, D., ABBASSI, H., RIVALLAN, G., COTTEE, J.P. and GUITTET, M. (1997) Passive protection of specific pathogen free chicks against infectious bursal disease by in-ovo injection of semi-purified egg-yolk antiviral immunoglobulins. Journal of Veterinary Medicine B44: 371-383.CrossRefGoogle Scholar
FULTON, R.M., NERSESSIAN, B.N. and REED, W.M. (2002) Prevention of Salmonella enteritidis infection in commercial ducklings by oral chicken egg-derived antibody alone or in combination with probiotics. Poultry Science 81: 34-40.CrossRefGoogle ScholarPubMed
GAST, R.K., PORTER, R.E. JR and HOLT, P.S. (1997) Assessing the sensitivity of egg yolk antibody testing for detecting Salmonella enteritidis infections in laying hens. Poultry Science 76: 798-801.CrossRefGoogle ScholarPubMed
GHARAIBEH, S., MAHMOUD, K. and AL-NATOUR, M. (2008) Field evaluation of maternal antibody transfer to a group of pathogens in meat-type chickens. Poultry Science 87: 1550-1555.CrossRefGoogle ScholarPubMed
GIRARD, F., BATISSON, I., MARTINE, G., BRETON, C., HAREL, J. and FAIRBROTHER, J.M. (2006) Use of virulence factor-specific egg yolk-derived immunoglobulins as a promising alternative to antibiotics for prevention of attaching and effacing Escherichia coli infections. FEMS Immunology and Medical Microbiology 46: 340-350.CrossRefGoogle ScholarPubMed
GOTTSTEIN, B. and HEMMELER, E. (1985) Egg yolk immunoglobulin Y as an alternative antibody in the serology of echinococcosis. Zeitschrift for Parasitenkunde 71: 273-276.CrossRefGoogle ScholarPubMed
GORBACH, S.L. (2001) Antimicrobial use in animal feed-time to stop. New England Journal of Medicine 345: 1202-1203.CrossRefGoogle ScholarPubMed
GRAHAM, J.P., BOLAND, J.J. and SIRBERGELD, E. (2007) Growth promoting antibiotics in food animal production: An Economic Analysis. Public Health Reports 122: 79-87.CrossRefGoogle ScholarPubMed
GURTLER, M., METHNER, U., KOBILKE, H. and FEHLHABER, K. (2004) Effect of orally administered egg yolk antibodies on Salmonella enteritidis contamination of hen's eggs. Journal of Veterinary Medicine B Infectious Disease Veterinary Public Health 51: 129-134.CrossRefGoogle ScholarPubMed
HAGAN, J.C., ASHTON, N.J., BRADBURY, J.M. and MORGAN, K.L. (2004) Evaluation of an egg yolk enzyme-linked immunosorbent assay antibody test and its use to assess the prevalence of Mycoplasma synoviae in UK laying hens. Avian Pathology 33: 93-97.CrossRefGoogle ScholarPubMed
HAMAL, K.R., BURGESS, S.C., PEVZNER, I.Y. and ERF, G.F. (2006) Maternal antibody transfer from dams to their egg yolks, egg whites, and chicks in meat lines of chickens. Poultry Science 85: 1364-1372.CrossRefGoogle ScholarPubMed
HATTA, H., OZEKI, M. and TSUDA, K. (1997) Egg yolk antibody Ig Y and its application, in: YAMAMOTO, T., JUNEJA, L.R., HATTA, H. & KIM, M. (Eds) Hen Eggs: Their Basic and Applied Science, pp. 151-178 (Florida, CRC Press).Google Scholar
HOLT, P.S., STONE, H.D., GAST, R.K. and GREENE, C.R. (2000) Application of the agar gel precipitin test to detect antibodies to Salmonella enterica serovar enteritidis in serum and egg yolks from infected hens. Poultry Science 79: 1246-1250.CrossRefGoogle ScholarPubMed
KARIYAWASAM, S., WILKIE, B.N. and GYLES, C.L. (2004) Resistance of broiler chickens to Escherichia coli respiratory tract infection induced by passively transferred egg-yolk antibodies. Veterinary Microbiology 98: 273-284.CrossRefGoogle ScholarPubMed
KARLSSON, M., KOLLBERG, H. and LARSSON, A. (2004) Chicken IgY: utilizing the evolutionary advantage. World's Poultry Science Journal 60: 341-348.CrossRefGoogle Scholar
KITAGUCHI, K., MINOURA, M., NORITAKE, M., MIZUTANI, M., KINOSHITA, K., HORIO, F. and MURAI, A. (2008) Determination of immunoglobulin Y concentration in yolk extract prepared by water dilution method: Comparisons among three strains of chickens. The Journal of Poultry Science 45: 82-87.CrossRefGoogle Scholar
KO, K.Y. and AHN, D.U. (2007) Preparation of immunoglobulin Y from egg yolk using ammonium sulfate precipitation and Ion exchange chromatography. Poultry Science 86: 400-407.CrossRefGoogle ScholarPubMed
KWEON, C.H., KWON, B.J., WOO, S.R., KIM, J.M., WOO, G.H., SON, D.H., HUR, W. and LEE, Y. S. (2000) Immunoprophylactic effect of chicken egg yolk immunoglobulin (Ig Y) against porcine epidemic diarrhea virus (PEDV) in piglets. Journal of Veterinary Medical Sciences 62: 961-964.CrossRefGoogle Scholar
LARSSON, A., BALOW, R.M., LINDAHL, T.L. and FORSBERG, P.O. (1993) Chicken antibodies: taking advantage of evolution--a review. Poultry Science 72: 1807-1812.CrossRefGoogle ScholarPubMed
LEE, E.N., SUNWOO, H.H., MENNINEN, K. and SIM, J.S. (2002) In vitro studies of chicken egg yolk antibody (IgY) against Salmonella enteritidis and Salmonella typhimurium . Poultry Science 81: 632-641.CrossRefGoogle ScholarPubMed
LEE, S.B., MINE, Y. and STEVENSO, R.M. (2000) Effects of hen egg yolk immunoglobulin in passive protection of rainbow trout against Yersinia ruckeri. Journal of Agricultural and Food Chemistry 48: 110-115.CrossRefGoogle ScholarPubMed
LESLIE, G.A. and CLEM, L.W. (1969) Phylogeny of immunoglobulin structure and function. III. Immunoglobulins of the chicken. The Journal of Experimental Medicine 130: 1337-1352.CrossRefGoogle Scholar
LESLIE, G.A., WILSON, H.R. and CLEM, L.W. (1971a) Studies on the secretory immunologic system of fowl. I. Presence of immunoglobulins in chicken secretions. Journal of Immunology 106: 1441-1446.CrossRefGoogle ScholarPubMed
LESLIE, G.A., CRANDALL, R.B. and CRANDALL, C.A. (1971b) Studies on the secretory immunologic system of fowl. II. Immunoglobulin-producing cells associated with mucous membranes. Immunology 21: 983-987.Google ScholarPubMed
LEVESQUE, S., MARTINEZ, G. and FAIRBROTHER, J.M. (2007) Improvement of adjuvant systems to obtain a cost-effective production of high levels of specific IgY. Poultry Science 86: 630-635.CrossRefGoogle ScholarPubMed
LI, X., NAKANO, T., SUNWOO, H.H., PAEK, B.H., CHAE, H.S. and SIM, J.S. (1998) Effects of egg and yolk weights on yolk antibody (IgY) production in laying chickens. Poultry Science 77: 266-270.CrossRefGoogle ScholarPubMed
LOEKEN, M.R. and ROTH, T.F. (1983) Analysis of maternal IgG subpopulations which are transported into the chicken oocyte. Immunology 49: 21-28.Google ScholarPubMed
MALIK, M.W., AYUB, N. and QURESHI, I.Z. (2006) Passive immunization using purified IgYs against infectious bursal disease of chickens in Pakistan. Journal of Veterinary Science 7: 43-46.CrossRefGoogle ScholarPubMed
MALMARUGAN, S., RAMAN, M., JAISREE, S. and ELANTHALIR, P. (2005) Egg immunoglobulins - an alternative source of antibody for diagnosis of infectious bursal disease. Veterinarski Arhiv 75: 49-56.Google Scholar
MILES, R.D., BUTCHER, G.D., HENRY, P.R. and LITTELL, R.C. (2006) Effect of antibiotic growth promoters on broiler performance, intestinal growth parameters, and quantitative morphology. Poultry Science 85: 476-485.CrossRefGoogle ScholarPubMed
NILSSON, E., LARSSON, A., OLESEN, H.V., WEJAKER, P. and KOLLBERG, H. (2008) Good effect of IgY against Pseudomonas aeruginosa infections in cystic fibrosis patients. Pediatric Pulmonology 43: 892-899.CrossRefGoogle ScholarPubMed
NILSSON, E. and LARSSON, A. (2007) Stability of chicken IgY antibodies freeze-dried in the presence of lactose, sucrose and threalose. The Journal of Poultry Science 44: 58-62.CrossRefGoogle Scholar
O'FARRELLY, C., BRANTON, D. and WANKE, C.A. (1992) Oral ingestion of egg yolk immunoglobulin from hens immunized with an enterotoxigenic Escherichia coli strain prevents diarrhea in rabbits challenged with the same strain. Infection and Immunity 60: 2593-2597.CrossRefGoogle ScholarPubMed
OPITZ, H.M., El-BEGEARMI, M., FLEGG, P. and BEANE, D. (1993) Effectiveness of five feed additives in chicks infected with Salmonella enteritidis phage type 13a. Journal of Applied Poultry Research 2: 147-153.CrossRefGoogle Scholar
OWUSU-ASIEDU, A., NYACHOTI, C.M., BAIDOO, S.K., MARQUARDT, R.R. and YANG, X. (2003) Response of early-weaned pigs to an enterotoxigenic Escherichia coli (K88) challenge when fed diets containing spray-dried porcine plasma or pea protein isolate plus egg yolk antibody. Journal of Animal Science 81: 1781-1789.CrossRefGoogle ScholarPubMed
ÖZPINAR, H., ERHARD, M.H., AYTUG, N., ÖZPINAR, A. and BAKLACI, C. et al. (1996) Dose-dependent effects of specific egg-yolk antibodies on diarrhea of newborn calves. Preventive Veterinary Medicine 27: 67-73.CrossRefGoogle Scholar
PIELA, T.H., GULKA, C.M., YATES, V.J. and CHANG, P.W. (1984) Use of egg yolk in serological tests (ELISA and HI) to detect antibody to Newcastle disease, infectious bronchitis, and Mycoplasma gallisepticum. Avian Diseases 28: 877-883.CrossRefGoogle ScholarPubMed
REILLY, R.M., DOMINGO, R. and SANDHU, J. (1997) Oral delivery of antibodies. Future pharmacokinetic trends. Clinical Pharmacokinetics 32: 313-323.CrossRefGoogle ScholarPubMed
ROSE, M.E., ORLANS, E. and BUTTRESS, N. (1974) Immunoglobulin classes on the hen's egg: their segregation in yolk and white. European Journal of Immunology 4: 521-523.CrossRefGoogle ScholarPubMed
ROSE, M.E. and ORLANS, E. (1981) Immunoglobulins in the egg, embryo and young chick. Developmental and Comparative Immunology 5: 15-20.CrossRefGoogle ScholarPubMed
SARKER, S.A., CASSWALL, T.H., JUNEJA, L.R., HOQ, E., HOSSAIN, I., FUCHS, G.J. and HAMMARSTROM, L. (2001) Randomized, placebo-controlled, clinical trial of hyperimmunized chicken egg yolk immunoglobulin in children with rotavirus diarrhea. Journal of Pediatric Gastroenterology and Nutrition 32: 19-25.Google ScholarPubMed
SCHADE, R., STAAK, C., HENDRIKSEN, C., ERHARS, M. and HUGL, H. et al. (1996) The production of avian (egg yolk) antibodies: IgY. ATLA 24: 925-934.Google Scholar
SHIMIZU, M., NAGASHIMA, H., HASHIMOTO, K. and SUZUKI, T. (1994) Egg yolk antibody (IgY) stability in aqueous solution with high sugar concentrations. Journal of Food Science 59: 763-765.CrossRefGoogle Scholar
SHIN, J.H., YANG, M., NAM, S.W., KIM, J.T., MYUNG, N.H., BANG, W.G. and Roe, I.H. (2002) Use of egg yolk-derived immunoglobulin as an alternative to antibiotic treatment for control of Helicobacter pylori infection. Clinical and Diagnostic Laboratory Immunology 9: 1061-1066.Google ScholarPubMed
STEDMAN, R.A., SINGLETON, L. and BOX, P.G. (1969) Purification of Newcastle disease virus antibody from the egg yolk of the hen. Journal of Comparative Pathology 79: 507-516.CrossRefGoogle ScholarPubMed
SUGITA-KONISHI, Y., SHIBATA, K., YUN, S.S., HARA-KUDO, Y., YAMAGUCHI, K. and KUMAGAI, S. (1996) Immune functions of immunoglobulin Y isolated from egg yolk of hens immunized with various infectious bacteria. Bioscience, Biotechnology and Biochemistry 60: 886-888.CrossRefGoogle ScholarPubMed
SUNWOO, H.H., LEE, E.N., MENNINEN, K., SURESH, M.R. and SIM, J.S. (2002) Growth inhibitory effect of chicken egg yolk antibody (IgY) on Escherichia coli O157: H7. Journal of Food Science 67: 1486-1494.CrossRefGoogle Scholar
SUNWOO, H.H., NAKANO, T., DIXON, W.T. and SIM, J.S. (1996) Immune responses in chickens against lipopolysaccharide of Escherichia coli and Salmonella typhimurium. Poultry Science 75: 342-345.CrossRefGoogle ScholarPubMed
TELLEZ, G., PETRONE, V.M., ESCORCIA, M., MORISHITA, T.Y., COBB, C.W., VILLASENOR, L. and PROMSOPONE, B. (2001) Evaluation of avian-specific probiotic and Salmonella enteritidis-, Salmonella typhimurium-, and Salmonella Heidelberg-specific antibodies on cecal colonization and organ invasion of Salmonella enteritidis in broilers. Journal of Food Protection 64: 287-291.CrossRefGoogle ScholarPubMed
THOMAS, E., BOUMA, A., VAN EERDEN, E., LANDMAN, W.J.M., VAN KNAPEN, F., STEGEMAN, A. and BERGWERFF, A.A. (2006) Detection of egg yolk antibodies reflecting Salmonella enteritidis infections using a surface plasmon resonance biosensor. Journal of Immunological Methods 315: 68-74.CrossRefGoogle ScholarPubMed
TSUBOKURA, K., BERNDTSON, E., BOGSTEDT, A., KAIJSER, B., KIM, M., OZEKI, M. and L. HAMMARSTROM, L. (1997) Oral administration of antibodies as prophylaxis and therapy in Campylobacter jejuni-infected chickens. Clinical and Experimental Immunology 108: 451-455.CrossRefGoogle ScholarPubMed
WILKIE, D.C. (2006) Non-antibiotic approaches to control pathogens in the gastrointestinal tract of the broiler chicken. Ph.D. Thesis, University of Saskatchewan.Google Scholar
WILKIE, D.C., VAN KESSEL, A.G., DUMONNCEAUX, T.J. and DREW, M.D. (2006) The effect of hen-egg antibodies on Clostridium perfringens colonization in the gastrointestinal tract of broiler chickens. Preventive Veterinary Medicine 74: 279-292.CrossRefGoogle ScholarPubMed
WILLS, F.K. and LUGINBUHL, R.E. (1963) The use of egg yolk for passive immunization of chickens against Newcastle disease. Avian Diseases. 7: 5-12.CrossRefGoogle ScholarPubMed
WORLD HEALTH ORGANIZATION, (1997) The medical impact of antimicrobial use in food animals. Proceedings of WHO meeting, Berlin. pp. 1-21.Google Scholar
YOKOYAMA, H., HASHI, T., UMEDA, K., ICATLO, F.C. JR, KUROKI, M., IKEMORI, Y. and KODAMA, Y. (1997) Effect of oral egg antibody in experimental F18+ Escherichia coli infection in weaned pigs. Journal of Veterinary Medical Science 59: 917-921.CrossRefGoogle ScholarPubMed
YOKOYAMA, H., PERALTA, R.C., DIAZ, R., SENDO, S., IKEMORI, Y. and KODAMA, Y. (1992) Passive protective effect of chicken egg yolk immunoglobulins against experimental enterotoxigenic Escherichia coli infection in neonatal piglets. Infection and Immunity 60: 998-1007.CrossRefGoogle ScholarPubMed
YOKOYAMA, H., PERALTA, R.C., UMEDA, K., HASHI, T., ICATLO, F.C. JR, KUROKI, M., IKEMORI, Y. and KODOMA, Y. (1998) Prevention of fatal salmonellosis in neonatal calves, using orally administered chicken egg yolk Salmonella-specific antibodies. American Journal of Veterinary Research 59: 416-420.CrossRefGoogle ScholarPubMed
YOUNG, C.A., SILVERSIDES, F.G. and JONES, S.R.M. (2007) Chicken-derived IgY recognizes developing and mature stages of Loma salmonae (Microsporidia) in Pacific salmon, Oncorhynchus spp. Aquaculture 273: 398-404.CrossRefGoogle Scholar
ZHEN, Y.H., JIN, L.J., GUO, J., LI, X.Y., LU, Y.N., CHEN, J. and XU, Y.P. (2008) Characterization of specific egg yolk immunoglobulin (IgY) against mastitis-causing Escherichia coli. Veterinary Microbiology 130: 126-133.CrossRefGoogle ScholarPubMed