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Molecular targets of dietary phytochemicals for the alleviation of heat stress in poultry

Published online by Cambridge University Press:  25 February 2013

K. SAHIN ,
C. ORHAN ,
M.O. SMITH  and
N. SAHIN
K. SAHIN*
Affiliation:
Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey
C. ORHAN
Affiliation:
Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey
M.O. SMITH
Affiliation:
Department of Animal Science, The University of Tennessee, TN, USA
N. SAHIN
Affiliation:
Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey
*
Corresponding author: [email protected]
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Abstract

Heat stress compromises performance and productivity through reducing feed intake, while decreasing nutrient utilisation, growth rate, egg production, egg quality and feed efficiency, leading to economic losses in poultry. High temperatures can lead to oxidative stress associated with a reduced antioxidant status in the bird in vivo, as reflected by increased oxidative damage and lowered plasma concentrations of antioxidants. Several strategies are currently available to alleviate the negative effects of high environmental temperature on the performance of poultry. However, as it is expensive to cool buildings in which animals are housed, many efforts are focused on dietary manipulation. In terms of reducing the negative effects of environmental stress, antioxidants are used in poultry feed because of the reported benefits of these supplements, including their anti-stress effects. In this review, the mode of action of these supplements is investigated, and evidence is presented showing that phytochemicals can alter several cell signalling pathways. The agents include epigallocatechin-3-gallate (EGCG; green tea), lycopene (tomato) and resveratrol (red grapes, peanuts and berries). The cell-signalling pathways inhibited by EGCG include transcription factors (nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)) and nuclear factors (erythroid-derived 2-like 2 (Nrf2)) and activator protein-1 (AP-1) that regulate cyclooxygenase-2 (COX-2). This review will also address some of the mechanisms proposed for the heat stress preventive activity of EGCG, lycopene and resveratrol focusing on the induction of antioxidant enzymes (phase II enzymes) through the activation of the antioxidant response element (ARE) transcription system.

Keywords

heat stressphytochemicalspoultry
Type
Reviews
Information
World's Poultry Science Journal , Volume 69 , Issue 1 , March 2013 , pp. 113 - 124
Copyright
Copyright © World's Poultry Science Association 2013

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