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Mechanisms regulating drug and pesticide residue uptake by egg yolks: development of predictive models

Published online by Cambridge University Press:  18 September 2007

Dan J. Donoghue
Dan J. Donoghue
Affiliation:
Department of Poultry Science, University of Arkansas, Fayetteville, Arkansas 72701, USA
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Abstract

Drug and pesticide residues in edible poultry tissues and eggs are a human food safety concern. Quantifying and predicting the concentrations of residues in eggs is a particular challenge because of the unique aspects of egg development and compartmentalisation of the yolk and white. For a number of years, research efforts have been directed at examining residue incorporation nto eggs and developing models to predict residue incursion. This paper will review the physiology of egg yolk formation as it relates to residue incursion, the models developed to understand and quantify residue patterns, and the use of magnetic resonance imaging to detect residue incorporation into eggs.

Keywords

Drugsegg yolkmodelpharmacokineticspesticidesresidues
Type
Research Article
Information
World's Poultry Science Journal , Volume 57 , Issue 4 , December 2001 , pp. 373 - 380
Copyright
Copyright © Cambridge University Press 2001

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References

Davison, K.L., Lamoureux, C.H. and Feil, V.J. (1984) Methoxychlor metabolism in chickens. Journal of AgricuIture and food Chemistry 32: 900–908CrossRefGoogle Scholar
Donoghue, D.J. and Hairston, H. (1999) Oxytetracycline transfer into chicken egg yolk or albumen. Poultry Science 78: 343–345CrossRefGoogle ScholarPubMed
Donoghue, D.J. and Hairston, H. (2000) Food safety concern: Antibiotics may rapidly contaminate egg albumen during the process of formation. British Poultry Science 41: 174–177CrossRefGoogle Scholar
Donoghue, D.J. and Myers, K. (2000) Imaging residue transfer into eggs. Journal of Agriculture and Food Chemistry 48: 6428–6430CrossRefGoogle Scholar
Donoghue, D.J., Hairston, H., Cope, C.V., Bartholomew, M.J. and Wagner, D.D. (1994) Incurred arsenic residues in chicken eggs. Journal of Food Protection 57: 18–223CrossRefGoogle ScholarPubMed
Donoghue, D.J., Hairston, H., Gaines, S., Bartholmew, M.J. and Donoghue, A.M. (1996) Modeling residue uptake in eggs: 1 similar drug residue patterns in developing yolks following injection with ampicillin or oxytetracycline. Poultry Science 75: 321–328CrossRefGoogle ScholarPubMed
Donoghue, D.J., Hairston, H., Henderson, M., Mcdonald, M., Gaines, S.A. and Donoghue, A.M. (1997a) Modeling residue uptake by eggs: yolks contain ampicillin residues even after drug withdrawal and non-delectability in the plasma. Poultry Science 76: 458–462CrossRefGoogle ScholarPubMed
Donoghue, D.J., Schenck, F., Hairston, H. and Podhorniak, L.V. (1997b) Modeling drug residue uptake by eggs: evidence of a consistent daily pattern of contaminant transfer into developing preovulatory yolks. Journal of Food Protection 60: 1251–1255CrossRefGoogle ScholarPubMed
Fiddler, W., Pensabene, J.W., Gates, R.A. and Donoghue, D.J. (1999) Supercritical fluid extraction of organochlorine pesticides in eggs. Journal of Agriculture and food Chemistry 47: 206–211CrossRefGoogle ScholarPubMed
Grau, C.R. (1976) Ring structure of avian egg yolk. Poultry Science 55: 1418–1422CrossRefGoogle Scholar
Griffin, H. D., Perry, M. M. and Gilbert, A.B. (1984) Yolk formation. In: Physiology arid Biochemistry of the Domestic Fowl, Volume 5 (Freeman, B.M., Ed.), Academic Press, New York, pp. 345–380Google Scholar
Hutchison, M. J., Lirette, A., Etches, R.J., Towner, R.A. and Janzen, E.G. (1992) Research note: an assessment of egg yolk structure using magnetic resonance imaging. Poultry Science 71: 2117–2121CrossRefGoogle ScholarPubMed
Johnson, A.L. (2000) Reproduction in the female. In: Sturkie's Avian Physiology (Whittow, G.C., Ed.), Academic Press, San Diego, pp. 569–596CrossRefGoogle Scholar
Kan, C.A. (1978) Accumulation of organochlorine pesticides in poultry: A review. Journal of Agriculture and Food Chemistry 26: 1051–1055CrossRefGoogle ScholarPubMed
Kan, C.A. and Petz, M. (2000) Residues of veterinary drugs in eggs and their distribution between yolk and white. Journal of Agricultiue and Food Chemistry 48: 6397–6403CrossRefGoogle ScholarPubMed
Katz, S.E., Fassbender, C.A. and Dowling, J.J. (1973) Oxytetracycline residues in tissue, organs, and eggs of poultry fed supplemented rations. Journal of Associated and Analytical Chemistry 56: 77–81Google ScholarPubMed
Nagata, T., Saeki, M., Iida, T., Kataoka, M. and Shikano, S. (1992) Determination of pyrimethamine and sulphadimethoxine residues in eggs by high performance liquid chromatography. British Poultry Science 33: 953–961CrossRefGoogle ScholarPubMed
Ridley, W.P., Fujiwara, H., Cheng, T. and Honegger, J.L. (1998) Metabolism of thiazopyr in laying hens. Journal of Agriculture and Food Chemistry 46: 4398–4405CrossRefGoogle Scholar
Roudaut, B., Moretain, J.P. and Boisseau, J. (1987a) Excretion of oxytetracycline in eggs after medication of laying hens. Food Additive contamination 4: 297–307CrossRefGoogle ScholarPubMed
Roudaut, B., Moretain, J.P. and Boisseau, J. (1987b) Résidus d'ampicilline dans les oeufs apr'es administration orale et parenterale. Record of Medial Veterinarian 163: 43–47Google Scholar
Schenck, F. J. and Donoghue, D.J. (2000) Determination of organochlorine and organo-phosphorus pesticide residues in eggs using a solid phase extraction cleanup. Journal of Agriculture and Food Chemistry 48: 6431–6434CrossRefGoogle Scholar
Warren, D. C. and Conrad, R.M. (1939) Growth of the hen's ovum. Journal of Agriculture and Research 58: 875–893Google Scholar