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Immunoactive, medicinal properties of mushroom and herb polysaccharides and their potential use in chicken diets

Published online by Cambridge University Press:  18 September 2007

F.C. Guo ,
H.F.J. Savelkoul ,
R.P. Kwakkel ,
B.A. Williams  and
M.W.A. Verstegen
F.C. Guo*
Affiliation:
Animal Nutrition Group, Wageningen University, PO Box 338, 6700, AH Wageningen, The Netherlands Institute of Animal Science and Veterinary Pharmaceutics, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China
H.F.J. Savelkoul
Affiliation:
Cell Biology and Immunology, Wageningen University, PO Box 338, 6700, AH Wageningen, The Netherlands
R.P. Kwakkel
Affiliation:
Animal Production Systems Group, Wageningen University, PO Box 338, 6700, AH Wageningen, The Netherlands
B.A. Williams
Affiliation:
Animal Nutrition Group, Wageningen University, PO Box 338, 6700, AH Wageningen, The Netherlands
M.W.A. Verstegen
Affiliation:
Animal Nutrition Group, Wageningen University, PO Box 338, 6700, AH Wageningen, The Netherlands
*
*Corresponding author: e-mail: [email protected]
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Abstract

Chinese natural medicinal products as feed supplements have been used as growth and health promoters in farm animals in China for centuries. A current estimation of the number of Chinese natural medicines ranges between 6,000 and 8,000, of which less than 5% has immuno-active properties. Most of these medicinal products originate from plants. Polysaccharides are considered to be the most important components, which may act as immune enhancers or immuno-modulators. The relationship between polysaccharide structure and bio-activity is, however, not well understood. In this review, immune activities of the polysaccharides from two mushrooms, Lentinus edodes and Tremella fuciformis, and a herb, Astragalus membranaceus radix, are reported, based on studies in chickens, mice, rats and humans. It can be concluded from these studies that polysaccharides derived from these products can play important roles in: (1) stimulating the growth of immune organs such as spleen, thymus and bursa; (2) increasing the number and activities of many interdependent cell types such as T, B lymphocytes, macrophages, natural killer (NK) cells and lymphokine-activated killer (LAK) cells; (3) enhancing T-cell mediated immune response, such as an increased rate of T-lymphocyte transformation and proliferation; (4) enhancing humoral immune response, such as spleen and serum antibody production, the number of haemolytic plague forming cells (PFC) and haemolysin production and (5) inducing secretion and production of cytokines and complements of T-cells and NK cells.

Today's poultry producers are confronted by numerous prophylactic techniques to prevent diseases. The immuno-active polysaccharides from mushrooms and herbs might be good candidates as health promoting feed additives in poultry diets. Further studies are needed to investigate the effects of such bioactive components to improve productive performance in chicken and to elucidate the possible modes of action related to the gut ecosystem and the immune response.

Keywords

mushroomherbpolysaccharidesphysico-chemicalimmunehealthchicken
Type
Reviews
Information
World's Poultry Science Journal , Volume 59 , Issue 4 , December 2003 , pp. 427 - 440
Copyright
Copyright © Cambridge University Press 2003

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References

De baets, S. and Vandamme, E.J. (2001) Extra-cellular Tremella polysaccharides: Structure, properties and applications. Biotechnology Letters 23 (17): 1361–1366.Google Scholar
Gibson, G.R. and Roberfroid, M.B. (1995) Dietary modulation of the human colonic microflora: introducing the concept of prebiotics. J. Nutr. 125: 1401.CrossRefGoogle Scholar
Guo, F.C. (2003)mushroom and herb polysaccharides as alternatives for antimicrobial growth promoters in poultry. PhD thesis, Wageningen University.Google Scholar
Hassan, H. (1988) Biosynthesis and regulation of superoxide dismutases. Free Radical Biol. Med. 5: 377.Google Scholar
Huisman, M.M.H., Schols, H.A. and Voragen, A.G.J. (1998) Cell wall polysaccharides from soybean meal; isolation and characterization. Carbohydr. Polym. 37: 87–95.Google Scholar
Jin, M.R., Bok, J.W., Shim, M.J., Choi, E.O. and Kim, B.K. (1991) Studies on constituents of the higher fungi of Korea (LXIX): Anti-tumor components of the cultured mycelia of Lentinus edodes . Seoul University Journal of Pharmaceutical Sciences 16(0): 66–96.Google Scholar
Jones, K. (1998) Shiitake: a major medicinal mushroom. Alternative and Complementary Therapies 2: 53–59.CrossRefGoogle Scholar
Lee, S.S., Hong, S.W., Kim, S.H. and Kim, B.C. (2001) Several genes expressed during morphogenesis of Lentinus edodes (ImHyup-1). Microbiology 29 (3): 135–141.Google Scholar
Len, R., Wolda, S., Moon, E., Esselstyn, J., Hertel, C. and Lerner, A. (2002) PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular CAMP. Cellular Signalling 14 (3): 277–284.Google Scholar
Li, H.F., Waisman, T., Maimon, Y., Shakhar, K., Rosenne, E. and Shamgar, B.E. (2001) The effects of a Chinese herb formula, anti-cancer number one (ACNO), on NK cell activity and tumor metastasis in rats. International Immunopharmacology 1(11): 1947–1956.Google Scholar
Li, X.Y. (2000) Immuno-modulating components from Chinese medicines. Pharmaceutical Biology 38 (Supplement): 33–40.Google Scholar
Lien, E.J. and Gao, H. (1990) Higher plant polysaccharides and their pharmacological activities. Int. J. Oriental Med. 15: 123.Google Scholar
Liu, F., Ooi, V.E.C. and Fung, M.C. (1999a). Analysis of immuno-modulating cytokine mRNAs in the mouse induced by mushroom polysaccharides. Life Sciences 64 (12): 1005–1011.Google Scholar
Lizuka, N., Miyamoto, K. and Hazama, S. (2000) Anticachectic effects of Coptidis rhizoma, an anti-inflammatory herb, on esophageal cancer cells that produce interleukin 6. Cancer Letters, 158 (1): 35–41.Google Scholar
Ma, X.Q., Shi, Q., Duan, J.A., Dong, T.T. and Tsim, K.W. (2002) Chemical analysis of Astragalus Radix (Huangqi) in China: a comparison with its adulterants and seasonal variations. J Agric Food Chem. 50(17): 4861–6.Google Scholar
Miles, P.G. and Chang, S.T. (1997) Mushroom Biology – Concise Basics and Current Developments. World Scientific. Singapore. pp 194.Google Scholar
Min, S.D. (1996) Medicinal value of fungi. Actu Edulis Fungi. 3(4): 55–64.Google Scholar
Ratcliffe, J. (2000) British supermarkets: forging changes in poultry nutrition. Proc. Australian Poultry Science Symposium 12: 25–31.Google Scholar
Rolfe, R.D. (2000) The role of probiotic cultures in the control of gastro-intestinal health. J. Nutr. 130 (2 suppl.): 396S–402S.Google Scholar
Royse, D.J., Schisler, L.C. and Diehle, D.A. (1985). Shiitake mushrooms – consumption, production and cultivation. Interdisciplinary Science Review 10 (4): 329.Google Scholar
Salyers, V.G., Park, Y.W. and Gray, C. (1977) Effects of mannan oligosaccharide (MOS) on aflatoxicosis, serum, liver, and egg cholesterol and egg production in chickens. Assoc. Res Dir. 11th Biennial Research Symposium.Google Scholar
Satonori, K., Yuki, A. and Fumio, E. (1999) Effects of Astragalus Radix extract on carcinogenesis, cytokine production, and cytotoxicity in mice treated with a carcinogen, N- butyl- N'- butanol- nitrosoamine. Cancer Iuvestigation 17 (1): 30–35.Google Scholar
Shon, Y.H., Kim, J.H. and Nam, K.S. (2002) Effect of Astragalus radix extract on lipopolysaccharide- induced inflammation in human amnion. Biological& Pharmaceutical Bullerin 25 (1): 77–80.CrossRefGoogle ScholarPubMed
Singer, R. (1961) Mushrooms and Truffles. Interscience Publishers, Inc., New York, NY.Google Scholar
Stamets, P. (2000) Growing gourmet and medicinal mushrooms. Ten Speed Press, Berkeley, CA.Google Scholar
Wang, R.J., LI, D.F. and Bourne, S. (1998) Can 2000 years of herbal medicine history help us solve problems in the year 2000? pp 273–291. In: Biotechnology in the feed industry. Proceedings of Alltech’S 14th AnnuulSysmposium, Lyons, T.P. & Jacques, K.A., Nottingham University Press.Google Scholar
Wargovich, M.J., Woods, C., Hollis, D.M. and Zander, M.E. (2001) Herbals, cancer prevention and health. J. of Nutr. 131 (11 Suppl): 3034–3036.CrossRefGoogle ScholarPubMed
Williams, B.A., Tamminga, S. and Verstegen, M.W.A. (2000) Fermentation kinetics to assess microbial activity of gastro-intestinal microflora. Pages 97–100 in An EAAP Satellite Symposium on Gas Production: Fermentation Kinetics for Feed Evaluation and to Assess Microbial Activity. British Society of Animal Science. 08. 18–19. Wageningen, Netherlands.Google Scholar
Xia, E.N. and Cheng, Q.H. (1988) Isolation, analysis and bioactivities of Trcmella fuciformis fruit body polysaccharides. Acta Mycologica Sinica. 7(3): 166–174.Google Scholar
Zhou, R.H. (1993) Resource science of Chinese medicinal materials (in Chinese), pp. 19–32. Bejing: China Medicinal & Pharmaceutical Science Press.Google Scholar
Zhou, Y.P. (1998) Guidelines for application of Chinese material medica. pp. 27–653. Chinese Muterial Medica (chemistry, pharmacology and applications) Nedichin, B.V. China-Netherlands. Medical and pharmaceutical center Groningen, The Netherlands.Google Scholar
Cheng, F.S., Hu, T.J. and Liang, J.L. (1998) Enhancement of Marek's disease vaccine by 8301 polysaccharide in chickens. J. of Traditional Chinese Vet. Medicine (in Chinese) 1: 8–9.Google Scholar
Chi, Y.J., Li, Q.Z. and Yu, H.X. (1998) Effect of Astragalus mungholicus Bga polysaccharide on superoxide dismutase (SOD) activity in avian myelocytic leukemia virus (VAMV) infected chicks. Helungjiung Animal Science and Vet. Medicine (in Chinese) 2: 3–5.Google Scholar
Fan, B.T., Yuan, Y.L. and Liang, J.L. (1993) Study of mechanism of enhanced efficacy of avian cholera vaccine by 8301 polysaccharide. J. of Traditional Chinese Vet. Medicine (in Chinese) 1: 5–10.Google Scholar
Hu, T.J., Fan, B.T. and Huang, Q.Z. (1995) Effect of 8301 polysaccharide on spleen IL-2 production in rats. Chinese J of Vet. Science and Technology (in Chinese) 25(1): 28.Google Scholar
Hu, T.J., Liang, J.L. and Cheng, F.S. (1998) The use of 8301 polysaccharide as an adjuvant in coccidial infected chickens. J. of Grass und Livestock (in Chinese) 6: 5–7.Google Scholar
Hu, T.J., Liang, J.L. and Dong, M.X. (1996) Effect of 8301 polysaccharide on serum IFN-γ titers in chickens. Endemic Disease Bulletin (in Chinese) 11: 6–7.Google Scholar
Huang, N.L. (1982) Cultivation of Trentella fuciformis in Fujian, China. Mushroom Newsl. Trop. (in Chinese) 2(3): 2–5.Google Scholar
Huang, Q.S., Lu, G.B., LI, Y.C. and Guo, J.H. (1982) Study on the polysaccharides of “Huang Qi’ (Astragalus mongholicus Bung). Acta Pharmaceutica Sinica (in Chinese) 17(3): 200–206.Google Scholar
Li, C.M. (1998) Chinese Herb Medicine Feed Additives (in Chinese), pp. 11–235, Beijing: Chinese Agricultural University Press.Google Scholar
Li, X.Y. (1989) Pharmacological study of Astragalus radix polysaccharides 2: An immuno- pharmacology study. Chinese Medicine (in Chinese) ll(5): 26–38.Google Scholar
Liang, H.P. (1996) Mechanism of the cellular immune function suppression and study on immune regulation by herbs in injured rats. Journal of Third Army Medical University (in Chinese) 18: 352.Google Scholar
Liang, H.P., Zhang, Y. and Geng, B. (1994) Effect of Astragalus membranacea radix on cellular immunity in burn rats. Journal of China Plastic and Burn Surgery (in Chinese) 10(2): 138–141.Google Scholar
Liang, J.L., Hu, T.J. and Fan, B.T. (1995) Experiment of 8301 polysaccharide inducing IFN production in rats. J. of Traditional Chinese Vet. Medicine (in Chinese) 4: 12–13.Google Scholar
Liu, J.X., Wang, C.Y. and Bai, Y.M. (1999c). Preparation of immuno-active Chinese herbal formulation and safe efficacy test. Chinese J. of Veterinary Science and Technology (in Chinese) 29(8): 23–25.Google Scholar
Liu, Y.J., Li, Q.Z. and Hao, Y.H. (1999b) Effects of Lentinan and Astragalan on IL-2 inductive activity and lymphocyte proliferative reaction in chicks infected with Marek's disease. J. of China Vet. Medicine (in Chinese) 25(7): 3–5.Google Scholar
Mao, X.J. (1988) Effect of Astragalus membranacea Radix polysaccharide on humoral immunity in rats. J. of China Immunology (in Chinese) 4(3): 158.Google Scholar
Mao, X.J. (1989) Immune opsonic action of Astragalus membranacea radix polysaccharide. China Pharmacology Bulletin (in Chinese) 5: 367.Google Scholar
Pang, F.H., Xie, M.Q. and Ling, H.H. (2000) The investigation of immuno-dulators tested for the results on the control of a coccidial infection. Chinese J. of Vet. Parasitology (in Chinese) 8(3): 1–3.Google Scholar
Qi, Z.S. (1987) Review on chemical study of Astragalus membranacea Radix . Chinese Traditional and Herbal Drugs (in Chinese) 18(5): 41–29.Google Scholar
Qu, Q.H., Chi, Y.J., Li, Q.Z. and Xu, B.R. (1997) Effect of Astragulus mongholicus Bga and Lentinus edodes polysaccharides on Se-GSHPX activity in chicks. Helongjiang Animal Science and Vet. Medicine (in Chinese) 5: 8–9.Google Scholar
Qu, Q.H., Li, Q.Z. and Xu, B.R. (1998) Effect of Astragalus mongholicus Bga and Lentinus edodes polysaccharide on Se-GSHPX activity in avian myelocytic leukemia virus (VAMV) infected chicks. Helongjiang Animal Science and Vet. Medicine (in Chinese) 4: 1–2.Google Scholar
Qun, L., Luo, Q. and Zhang, Z.Y. (1999) Effects of Astragalus membranacea radix on IL-2/1L-2R system in patients with maintained hemodialysis. Clin Nephrol. (in Chinese) 52: 333–4.Google Scholar
Shinya, A., Nobuya, K., Kiyoshi, T., Shigern, N., Hiroshi, I., Masaaki, N., Hiroaki, U. and Tsuyoshi, A. (1991) Reinforcement of inducing activity of lymphocyte activators by Lentinus polysaccharides in gastric carcinoma patient. Surgery (in Chinese) 1: 874.Google Scholar
Tang, X.M., Liu, J.G. and Sun, D.L. (1997) Effect of Astragalus membranacea radix polysaccharide on activity of NK cells in peripheral blood in chicks. J of China Vet. Medicine (in Chinese) 23(1): 44–45.Google Scholar
Wang, G. (1992) Effect of Astragalus membranacea radix polysaccharide on activities of lymphocyte- activated killer (LAK) cells. China Hygiene. Journal (in Chinese) 11: 233.Google Scholar
Wang, L.R., Liang, Z.H. and Feng, W. (1997). lmmunodulation of Astrngalus memhranacea radix and Acanthopanax gracilistylus. Journal of China Experimental Clinic Immunology (in Chinese) 9(4): 61–66.Google Scholar
Wei, P., Li, Q.Z. and Hao, Y.H. (1997) Effect of Astragalus mongholicus Bga and Lentinus edodes polysaccharide on lipid peroxide (LPO) content in Marek's disease infected chicks. J. of Traditional Chinese Vet. Medicine (in Chinese) 4: 3–4.Google Scholar
Wu, S., Zhou, Z.Y. and Pan, L.X. (1996). Effect of China Lentinus edodes polysaccharide on activity of NK cells in cancerous patients. Jiangsu Chinese Medicine (in Chinese) 17(9): 41.Google Scholar
Wu, W.T., Yu, P.H., Xia, E.N., Shi, W.X., Xu, B.R. and Cheng, Q.H. (1984) lsolation and purification of polysaccharides TF-A, TF-B and TF-C from the spores of Tremella fuciformis Berk and determination of their molar ratios. Acta Biochimica et Biophysica Sinica (in Chinese with English summary) 16(4): 393–398.Google Scholar
Wu, Y.H. and Wang, F. (1999) Research status on two-way immune regulating functions of herbs. J. of Traditional Chinese Vet. Medicine (in Chinese) 4: 19–22.Google Scholar
Xia, D. and Lin, Z.B. (1989) Effects of Tremella polysaccharides on immune function in mice. Acta Pharmucologica Sinica (in Chinese with English summary) 10(5): 453–456.Google Scholar
Xue, M. and Meng, X.S. (1996) Review on research progress and prosperous of immune activities of bio-active polysaccharides. J. of Traditionul Chinese Vet. Medicine (in Chinese) 3: 15–18.Google Scholar
Yang, H.C., Lu, G. and Lu, G. (1998) Effect of pollen polysaccharide from corns on immunological efficacy of Newcastle disease vaccine and egg drop syndrome vaccine in chickens. J. of Chinese Vet. Medicine (in Chinese) 24(6): 43.Google Scholar
Yang, J., Wu, M.C. and Zhang, S.H. (1999) Study on isolation, purification and characteristics of polysaccharide Le-III from the fruit body of Lentinus edodes. J. of Huazhong Agricultural University (in Chinese with English summary) 18(2): 188–190.Google Scholar
Yang, J., Wu, M.C. and Zhang, S.H. (2001) Isolation, purification and characterization of polysaccharides from the fruit body of Lentinus edodes (Berk.) Journal of Plant resources and Environment (in Chinese with English summary) 10(2): 4–6.Google Scholar
Yang, Y. and Feng, W.S. (1998) Brochures of isolation and extraction of chemical components from herbs (in Chinese), China Chinese Herb Medicine Press. Beijing.Google Scholar
Yu, J.G. and Zhu, L.Y. (2000) The use of Astragalus membranaceu Radi polysaccharide extract against infectious bursa disease in chickens. J. of Traditional Chinese Vet. Medicine (in Chinese with English summary) 6: 3–4.Google Scholar
Yuan, W.S. and Shi, S.M. (2000) Pharmacological functions of Chinese medicinal fungus Cordyceps sinensis and related species. J. of Food and Drug Analysis (in Chinese and English summary) 8(4): 248–257.Google Scholar
Yuan, Y.L., Fan, B.T. and Zhang, Y.X. (1993) Efficacy of 8301 polysaccharides as an adjuvant against avian Pusteurellosis in chickens. J. of Traditional Chinese Vet. Medicine (in Chinese) 3: 6–10.Google Scholar
Zhang, F.Y. (1991) Effect of Astragalus membranacea radix on CMSC in elders. Journal of lmmunology (in Chinese) 8(2): 3.Google Scholar
Zhang, L.C., Wang, J.B., Sun, Y.P., MA, D.Z., Shi, M.L. and Wang, Z.H. (1998a) Effect of a herb polysaccharide complex on immune organs morphology in chickens. Chinese J. of Vet. Science and Technology (in Chinese) 28(8): 26–28.Google Scholar
Zhang, L.C., Wang, J.B., Sun, Y.P., Ma, D.Z., Shi, M.L. and Wang, Z.H. (1998b) Effect of adding Chinese herb polysaccharide preparations to a Newcastle disease inactivated vaccine on the development of the immune organs in chickens. Chinese Journal of Vet. Science and Technology (in Chinese) 18(4): 378–381.Google Scholar
Zhang, Z.Z., Liang, X.M., Zhang, Q., Qing, and Lu, P.Z. (2001) Characterization and recognition key components in stragalus membranaceus . Acta Pharmaceutica Sinica (in Chinese with English summary) 36(7): 523–527.Google Scholar
Zhao, R.H., Zhang, H.Y. and Tiao, T. (1995) The resources and stock of the common use Chinese herb medicine in China. J. of Chinese Medicine (in Chinese) 20(12): 712.Google Scholar
Zhong, M., Zhang, D.S., Murata, J., Saiki, I. and Itaru, Y. (2001) Effects of Astragalus polysaccharide (APS) and Astragalus flavonoids (AF) on the cytotoxicity of LAK and NK cells in normal and tumor bearing mice. Sichuan Pharmaceutical Bulletin (in Chinese with English summary) 38(5): 718–722.Google Scholar
Zhong, P., Li, Q.Z., Ge, M., Gao, X.J. and Mao, F.J. (1998) Effect of Lentinus edodes and Astragalus membranace Radix polysacchilrides on lymphocytes' chemiluminescence. J. of Traditional Chinese Vet. Medicine (in Chinese) 3: 5–7.Google Scholar
Zhou, R.H. (1993) Resource science of Chinese medicinal materials (in Chinese), pp. 19–32. Bejing: China Medicinal & Pharmaceutical Science Press.Google Scholar