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Black vomit, gizzard erosion and gizzerosine

Published online by Cambridge University Press:  18 September 2007

M. Sugahara
M. Sugahara
Affiliation:
2-5-9 Terabun, Kamakura, Kanagawa 247, Japan1
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Abstract

Gizzerosine [2-amino-9-(4-imidazoyl)-7-azanonanoic acid] was isolated from a fish meal which caused black vomit in broiler chicks. Those given a diet containing fish meal which caused black vomit or synthetic DL-gizzerosine secreted excess gastric juice. The excess juice resulted in gizzard erosion and black vomit. In all the experiments, amongst chicks that died, those without gizzard perforation were greater in number than those with such lesions. It is considered that gizzard perforation by excess gastric juice is not the most serious lethal effect of gizzerosine. Chicks have been found to exhibit wide variation in sensitivity to gizzerosine. In a 4-week feeding trial of a fish meal that caused black vomit, 25 out of 100 died but nine grew normally. It should therefore be possible to estimate the maximum permissible concentration of gizzerosine in practical broiler diets. In the case of manufacturing facilities in which vapour is used to dry the fish meal indirectly, the conditions which avoid gizzerosine formation are known. It is desirable to determine safe conditions for fish meal drying when the process uses hot air heated by a flame.

Keywords

Black vomitbroilersfish mealgizzard erosiongizzerosine
Type
Research Article
Information
World's Poultry Science Journal , Volume 51 , Issue 3 , November 1995 , pp. 293 - 306
Copyright
Copyright © Cambridge University Press 1995

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References

Avila, G. and Balloun, S.L. (1974) Effect of anchovy fish meal in broiler diets. Poultry Science 53: 1372–1379CrossRefGoogle Scholar
Bierer, B.W., Carll, W.T., Eleazer, T.H. and Barnett, B.D. (1966) Gizzard erosion and lower intestinal congestion and ulceration due to feed and water deprivation in chickens of various ages. Poultry Science 45: 1408–1411CrossRefGoogle ScholarPubMed
Bird, H.R., Oleson, J.J., Elvehjem, C.A. and Hart, E.B. (1938) Effectiveness of chondroitin in preventing gizzard erosion in chicks. Journal of Biological Chemistry 126: 671–681CrossRefGoogle Scholar
Cover, M.S. and Paredes, F. (1971) Perforating ventricular ulceration in young chickens. Avian Disease 15: 609–610CrossRefGoogle ScholarPubMed
Harry, E.G., Tucker, J.F. and Laursen-Jones, A.P. (1975) The role of histamine and fish meal in the incidence of gizzard erosion and proventricular abnormalities in the fowl. British Poultry Science 16: 69–78CrossRefGoogle Scholar
Harry, E.G. and Tucker, J.F. (1976) Effect of orally administered histamine on the weight gain and the development of gizzard erosion in chicks. Veterinary Research 99: 206–207Google ScholarPubMed
Hino, T., Noguchi, T. and Naito, H. (1987) Effect of gizzerosine on acid secretion by isolated mucosal cells of chicken proventriculus. Poultry Science 66: 548–551CrossRefGoogle ScholarPubMed
Horaguchi, H., Masumura, T., Horikawa, H. and Sugahara, M. (1980) Gizzard erosion and ulceration in broiler chicks. 2. Effect of fish meal. Japanese Poultry Science 17: 351–357 (Japanese)CrossRefGoogle Scholar
Horikawa, H., Masumura, T., Hirano, S., Watanabe, E. and Ishibashi, T. (1992a) Effect of dietary gizzerosine on calcium content in the femur of chicks. Japanese Poultry Science 29: 221–227CrossRefGoogle Scholar
Horikawa, H., Masumura, T., Hirano, S., Watanabe, E. and Ishibashi, T. (1992b) Optimum dietary level of gizzerosine for maximum calcium content in the femur of chicks. Japanese Poultry Science 29: 361–367CrossRefGoogle Scholar
Horikawa, H., Masumura, T., Watanabe, E. and Ishibashi, T. (1993) Effect of dietary gizzerosine on contents of ash and calcium in the femur of young and ovariectomized mice. Animal Science and Technology (Japan) 64: 8–12Google Scholar
Ito, Y. and Noguchi, T. (1988) Physiological functions of gizzerosine, natural substance causes gizzard erosion for chicks. Seikagaku 60: 1168–1172 (Japanese)Google Scholar
Ito, Y., Noguchi, T. and Naito, H. (1985) Fluorometric determination of gizzerosine, a histamine H2-receptor antagonist discovered in feedstuffs, employing high-performance liquid chromatography. Analytical Biochemistry 15: 28–31CrossRefGoogle Scholar
Ito, Y., Terao, H., Noguchi, T. and Naito, H. (1988) Gizzerosine raises the intercellular cyclic adenosine-3′,5′-monophosphate level in isolated chicken proventriculus. Poultry Science 67: 1290–1294CrossRefGoogle Scholar
Janssen, W.M.M.A. (1971) The influence of feeding on gizzard erosion in broilers. Archiv für Geflügelkunde 35: 137–141Google Scholar
Jansen, W.M.M.A. and Germs, A.C. (1973) Gizzard erosion, meat flavour and vitamin E in broilers. Acta Agriculturae Scandinavica (Suppl.) 19: 72–73Google Scholar
Johnson, D.C. and Piendo, D.C. (1971) Gizzard erosion and ulceration in Peru broilers. Avian Disease 15: 835–837CrossRefGoogle ScholarPubMed
Kazama, T., Makino, A., Abe, M., Akaike, Y., Sugahara, M. and Taniguchi, T. (1980) Gizzard erosion and ulceration in broiler chicks. 1. Field outbreaks and reproduction of the disease. Japanese Poultry Science 17: 344–350 (Japanese)CrossRefGoogle Scholar
Kajie, A., Kajioka, S., Kurose, K. and Odakiri, M. (1980) Induction of gizzard erosion in broiler chickens by excess feeding of fish meal. Journal of the Japanese Society on Poultry Diseases 16: 132–138 (Japanese)Google Scholar
Kubena, L.F., Sadler, C.R., Haynes, R.L., Vardaman, T.H. and Deaton, J.W. (1976) Effect of fish meal and poultry byproduct meal on the small intestine and gizzard of broilers. Poultry Science 55: 30–33CrossRefGoogle ScholarPubMed
Masumura, T. (1980) Gizzard erosion and ulceration in broiler chicks. Relation to fish meal in diets. Journal of the Japanese Society on Poultry Diseases 16: 1–8 (Japanese)Google Scholar
Masumura, T. and Sugahara, M. (1982) The influence of heated fish meal inducing poultry gizzard erosion on rats. Japanese Journal of Zootechnical Science 53: 743–746 (Japanese)Google Scholar
Masumura, T. and Sugahara, M. (1984a) Physiological functions of gizzerosine (toxic substance of gizzard erosion in broiler chicks). Proceedings of Japanese Society for Animal Nutrition and Metabolism 28: 17–30Google Scholar
Masumura, T. and Sugahara, M. (1984b) Effect of supplemental lysine on gizzard erosion in broiler chicks. Japanese Poultry Science 21: 215–218 (Japanese)CrossRefGoogle Scholar
Masumura, T. and Sugahara, M. (1985) The effect of gizzerosine, a recently discovered compound in overheated fish meal, on the gastric acid secretion in chicken. Poultry Science 64: 356–361CrossRefGoogle ScholarPubMed
Masumura, T., Horaguchi, H., Horikawa, H. and Sugahara, M. (1981) Gizzard erosion and ulceration in broilers. 3. Toxic substance(s) in fish meal. Japanese Poultry Science 19: 98–104 (Japanese)CrossRefGoogle Scholar
Mori, K., Okazaki, T., Noguchi, T. and Naito, H. (1983) Synthesis of (±) gizzerosine, an inducer of gizzard erosion in broiler chicks. Agricultural Biological Chemistry 47: 2131–2132Google Scholar
Mori, K., Sugai, T., Maeda, Y., Okazaki, T., Noguchi, T. and Naito, H. (1985) Synthesis of the racemic and optically active forms of gizzerosine, the inducer of gizzard erosion in chicks. Tetrahedron 41: 5307–5311CrossRefGoogle Scholar
Ohta, Y., Ohashi, H., Enomoto, S. and Machida, Y. (1988) Simple measurement of gizzerosine in fish meals by high-performance liquid chromatography. Agricultural Biological Chemistry 52: 2817–2821Google Scholar
Okazaki, T., Noguchi, T., Igarashi, K., Sakagami, Y., Seto, H., Mori, K. et al. (1983) Gizzerosine, a new toxic substance in fish meal, causes severe gizzard erosion in chicks. Agricultural Biological Chemistry 47: 2949–2952Google Scholar
Senda, H., Okuda, M., Ida, K., Yamashita, H. and Yamaguchi, M. (1980) Gizzard erosion and ulceration of broilers induced by fish meal in the feed. Journal of the Japanese Society on Poultry Diseases 16: 69–75 (Japanese)Google Scholar
Shifrine, M., Adler, H.E. and Ousterhout, E. (1960) The pathology of chicks fed histamine. Avian Disease 4: 12–21CrossRefGoogle Scholar
Sugahara, M. (1984) Purification and structure determination of gizzerosine (toxic substance caused gizzard erosion in broiler chicks) and its physical activities. Journal of the Japanese Society on Poultry Diseases 20: 59–62 (Japanese)Google Scholar
Sugahara, M. (1993a) The quality of fishmeal produced in South America. Feeding 33: 57–61 (Japanese)Google Scholar
Sugahara, M. (1993b) The quality of fishmeal produced in South America. Feeding 33: 62–65 (Japanese)Google Scholar
Sugahara, M., Hattori, T. and Nakajima, T. (1987a) An early detection method for gizzerosine in fish meal using chick assay. Japanese Poultry Science 24: 348–353 (Japanese)CrossRefGoogle Scholar
Sugahara, M., Hattori, T. and Nakajima, T. (1987b) Relationship between growth rate and gastric acid secretion on gizzerosine administration to broiler chicks. Agricultural Biological Chemistry 51: 3137Google Scholar
Sugahara, M., Hattori, T. and Nakajima, T. (1987c) Lethal toxicity of gizzerosine for broiler chicks. Agricultural Biological Chemistry 51: 3423–3424Google Scholar
Sugahara, M., Hattori, T. and Nakajima, T. (1988a) Suppressing effect of cimetidine, sodium bicarbonate and magnesium-trisilicate for gizzard erosion in broiler chicks. Japanese Journal of Zootechnical Science 59: 306–310 (Japanese)Google Scholar
Sugahara, M., Hattori, T. and Nakajima, T. (1988b) Effect of synthetic gizzerosine on growth, mortality and gizzard erosion in broiler chicks. Poultry Science 67: 1580–1584CrossRefGoogle ScholarPubMed
Sugahara, M., Hattori, T. and Nakajima, T. (1992a) Effect of heating hours and temperature for the production of gizzerosine in fishmeal. Animal Science and Technology (Japan) 63: 1028–1031Google Scholar
Sugahara, M., Hattori, T. and Nakajima, T. (1992b) Effect of dietary gizzerosine from fishmeal on mortality and growth of broiler chicks. Animal Science and Technology (Japan) 63: 1234–1239Google Scholar
Sugahara, M., Hattori, T. and Nakajima, T. (1993c) Effect of low concentrations of gizzerosine in broiler chick diets. Japanese Poultry Science 30: 389–395CrossRefGoogle Scholar
Tepper, A.E. and Bird, H.R. (1942a) Gizzard lesions in day-old chicks. 1. Their relationship to subsequent growth and mortality and their prevalence. Poultry Science 21: 47–51CrossRefGoogle Scholar
Tepper, A.E. and Bird, H.R. (1942b) Gizzard lesions in day-old chicks. 2. The time of origin and factors influencing the cause of gizzard lesions in chicks. Poultry Science 21: 52–57CrossRefGoogle Scholar
Tepper, A.E. and Bird, H.R. (1942c) Gizzard lesions in day-old chicks. 3. Can severity of incidence be reduced by dietary control? Poultry Science 21: 108–110CrossRefGoogle Scholar
Wada, T., Hishiyama, T. and Ueno, J. (1987) Simple method of chemical analysis of a small quantity of gizzerosine. Scientific Feeds 32: 342–348 (Japanese)Google Scholar