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In the beginning: the multiple discovery of the first hormone herbicides

Published online by Cambridge University Press:  20 January 2017

James R. Troyer*
Affiliation:
Department of Botany, North Carolina State University, Raleigh, NC 27695-7612; [email protected]

Abstract

The discovery of the first systemic or hormone herbicides, 2,4-D, 2,4,5-T, and MCPA, initiated an agricultural revolution and modern weed science. The finding of these herbicides was a striking case of multiple independent discovery by four groups of workers in two countries, the United Kingdom and the United States: William G. Templeman and associates at Imperial Chemical Industries; Philip S. Nutman and associates at the Rothamsted Agricultural Experiment Station; Franklin D. Jones at the American Chemical Paint Company; and Ezra Kraus, John Mitchell, and associates at the University of Chicago and the U.S. Department of Agriculture. Because of wartime and commercial secrecy, the usual procedures of scientific publication and patent disclosure were not followed; instead, the first scientific report on these herbicides occurred in a publication by workers who were not original discoverers. Considerable confusion consequently resulted concerning the discovery and the discoverers. This confusion has not been completely dispelled in subsequent years. The present report summarizes the complete story, clarifies the chronology of the discoverers and their publications, and makes the case that all four groups of workers deserve credit for this revolutionary advance. The scientific background of the discovery and events in its immediate aftermath, especially the ticklish patent situation, are also briefly chronicled.

Type
Special Topics
Copyright
Copyright © Weed Science Society of America 

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References

Literature Cited

Adams, V. 1990. Chemical Warfare, Chemical Disarmament. Bloomington, IN: Indiana University Press. 276 p.Google Scholar
Allen, H. P., Brian, R. C., Downes, J. E., Mees, G. C., and Springett, R. H. 1978. Selective herbicides. Pages 3541 In Peacock, F. C., ed. Jealott's Hill: Fifty Years of Agricultural Research 1928–1978. Bracknell, Great Britain: Imperial Chemical Industries.Google Scholar
American Chemical Paint Co. v. Dow Chemical Co. 1947. Fed. Rep. 2nd Series 161:956960.Google Scholar
Anonymous. 1942. Synthetic plant hormones. Science (May 8 Suppl.):12.CrossRefGoogle Scholar
Anonymous. 1945a. A new weed-killer. Times (London) (March 28):8.Google Scholar
Anonymous. 1945b. Agricultural weed killer. A revolutionary discovery. Chem. Age 52:283.Google Scholar
Anonymous. 1945c. Revolutionary agricultural weed killer. Chem. Ind. (April 7):109110.Google Scholar
Anonymous. 1945d. Methoxone. Chem. Ind. (October 13):319.Google Scholar
Anonymous. 1945e. Methoxone. The new selective weedkiller. Chem. Age 53:331332.Google Scholar
Anonymous. 1945f. War against weeds. Time 45 (February 19): 6768.Google Scholar
Anonymous. 1945g. Briton claims new weed-killer. New York Times (October 9):8.Google Scholar
Anonymous. 1945h. A new selective weed killer. Ctry. Life 98:689.Google Scholar
Anonymous. 1946a. Science and life in the world. Science 103:662666.CrossRefGoogle Scholar
Anonymous. 1946b. 2,4-D—its future in weed control. Agric. Chem. 1 (May): 2022, 63.Google Scholar
Anonymous. 1946c. Blanket patent on synthetic weed killers. Science News Lett. 49:121.Google Scholar
Anonymous. 1946d. File 2,4-D patent suit. Agric. Chem. 1 (May): 21.Google Scholar
Anonymous. 1946e. 2,4-D patent holder in counter suit against Sherwin-Williams. Agric. Chem. 1 (June): 56.Google Scholar
Anonymous. 1947. 2,4-D patent suit settled out of court. Agric. Chem. 2 (November): 51.Google Scholar
Anonymous. 1953a. William Gladstone Templeman. Who's Who in British Science. London: Leonard Hill. p. 1258.Google Scholar
Anonymous. 1953b. Basic research lags application of growth regulators. J. Agric. Food Chem. 1:818.Google Scholar
Anonymous. 1958a. Royal Agricultural Society of England: award of research medal. Nature 181:15061507.Google Scholar
Anonymous. 1958b. Research medal for research work of benefit to agriculture. J. Roy. Agric. Soc. Engl. 118:181.Google Scholar
Anonymous. 1960. Ezra Kraus dies; plant scientist. New York Times (March 1):33.Google Scholar
Anonymous. 1964a. Franklin D. Jones, chemical inventor. New York Times (May 9):27.Google Scholar
Anonymous. 1964b. Died. Franklin Delavergne Jones. Time 83 (May 15): 110.Google Scholar
Anonymous. 1964c. Ag pioneer dies. Agric. Chem. 19 (June): 85.Google Scholar
Anonymous. 1979a. New year honours list of awards in full. Times (London) (January 1):9.Google Scholar
Anonymous. 1979b. Obituary. Dr. W. G. Templeman. Discovery of selective weed killers. Times (London) (November 27):12.Google Scholar
Ashby, E. 1960. Prof. E. J. Kraus. Nature 186:516.CrossRefGoogle Scholar
Bailey, S. 1960. Death takes noted horticulturist. Am. Fruit Grower 50 (4): 25.Google Scholar
Bausor, S. 1939. A new growth substance, β-naphthoxyacetic acid. Am. J. Bot. 27:415418.Google Scholar
Blackman, G. E. 1945a. Plant growth substances as selective herbicides. A comparison of certain plant growth substances and other selective herbicides. Nature 155:500501.Google Scholar
Blackman, G. E. 1945b. Recent developments in chemical methods for the selective control of weeds. J. Roy. Agric. Soc. Engl. 106:137150.Google Scholar
Blackman, G. E. 1946. Weed control in cereals by chemical means. J. Min. Agric. 53:1622.Google Scholar
Blaxter, K. and Robertson, N. 1995. From Dearth to Plenty. The Modern Revolution in Food Production. Cambridge: Cambridge University Press. 296 p.Google Scholar
Bovey, R. W. and Young, A. L. 1980. The Science of 2,4,5-T and Associated Phenoxy Herbicides. New York: J. Wiley. 462 p.Google Scholar
Boysen Jensen, P. 1910. Über die Leitung des phototropischen Reizes in Avenakeimpflanzen. Ber. Deutsch. Bot. Ges. 28:118120.Google Scholar
Boysen Jensen, P. 1911. La transmission de l'irritation phototropique dans l’Avena. Bull. Acad. R. Sci. Lett. Danemark 1:124.Google Scholar
Boysen Jensen, P. 1913. Über die Leitung des phototropischen Reizes in der Avenakoleoptile. Ber. Deutsch. Bot. Ges. 31:559566.Google Scholar
Brophy, L. P., Miles, W. D., and Cochrane, R. C. 1959. The Chemical Warfare Service: From Laboratory to Field. The United States Army in World War II. Volume 41. Washington, DC: Department of the Army. 498 p.Google Scholar
Burnet, I. M. 1967. The MCPA story. PANS, Section C, Weed Control 13:104110.Google Scholar
Canine, C. 1995. Dream Reaper. New York: Alfred A. Knopf. 300 p.Google Scholar
Carleton, R. M. 1945. New TCP kills toughest weeds. Better Homes Gard. 23 (February): 15, 93–95.Google Scholar
Cates, J. S. 1945. A knockout for weeds. Ctry. Gentleman 115 (1): 12, 33.Google Scholar
Cattell, J., ed. 1955. Hamner, Dr. Charles Leonard. American Men of Science. 9th ed., Volume 2. Lancaster, PA: R. R. Bowker. p. 463.Google Scholar
Cattell, J., ed. 1960. Jones, Franklin D(elavergne). American Men of Science. The Physical and Biological Sciences. 10th ed. Tempe, AZ: Jacques Cattell Press. p. 2041.Google Scholar
Ciesielski, T. 1872. Untersuchungen über die Abwärtskrümmung der Wurzel. Bei. Biol. Pflanz. 1:130.Google Scholar
Clark, R. W. 1965. Tizard. Cambridge, MA: MIT Press. 458 p.Google Scholar
Cozzens, S. E. 1989. Social Control and Multiple Discovery in Science. Albany, NY: State University of New York Press. 236 p.Google Scholar
Darwin, C. R. 1880. The Power of Movement in Plants. London: John Murray. 592 p.Google Scholar
Duncan, P. 1946. The British develop new weed killer. Agric. Chem. 1 (August): 37.Google Scholar
Fitting, H. 1909. Die Beeinflussung der Orchideenbluten durch die Bestäubing und durch andere Umstände. Ein entwicklunsphysiologische Studie aus den Tropen. Zeit. Bot. 1:186.Google Scholar
Fitting, H. 1910. Weitere entwicklungsphysiologische Untersuchungen an Orchideenbluten. Zeit. Bot. 2:225267.Google Scholar
Fletcher, W. W. and Kirkwood, R. C. 1982. Herbicides and Plant Growth Regulators. London: Granada. 408 p.Google Scholar
Fryer, J. D. 1980. Foreword. Pages 13 In C. Kirby. The Hormone Weedkillers. A Short History of Their Discovery and Development. Croyden, Great Britain: British Crop Protection Council.Google Scholar
Haagen Smit, A. J. and Went, F. W. 1935. A physiological analysis of the growth substance. Proc. Kon. Akad. Wet. Amst. 38:852857.Google Scholar
Hamner, C. L. and Tukey, H. B. 1944a. The herbicidal action of 2,4-dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid on bindweed. Science 100:154155.Google Scholar
Hamner, C. L. and Tukey, H. B. 1944b. Selective herbicidal action of midsummer and fall applications of 2,4-dichlorophenoxyacetic acid. Bot. Gaz. 106:232245.Google Scholar
Haynes, W., ed. 1949. American Chemical Paint Company. Pages 1719 In American Chemical Industry. The Chemical Companies. Volume 6. New York: D. Van Nostrand Company.Google Scholar
Hitchcock, A. E. 1935. Indole-3-n-propionic acid as a growth hormone and the quantitative measurement of plant response. Contr. Boyce Thompson Inst. 7:8795.Google Scholar
Hudson, H. G. 1946. Weed control in Norfolk. A new method. J. Min. Agric. 53:2227.Google Scholar
Irvine, V. 1938. Studies in growth promoting substances as related to xradiation and photoperiodism. Univ. Colo. Stud. 26 (1): 6970.Google Scholar
Jones, F. D. 1945a. New chemical weed killers. Am. Nurseryman 81 (March 1): 910.Google Scholar
Jones, F. D. 1945b. [Comments during discussion]. Pages 71, 72 in Proceedings of the 2nd Annual Meeting, North Central States Weed Control Conference.Google Scholar
Jones, F. D. 1945c. Methods and compositions for killing weeds. U.S. patent 2,390,941. Application in Canada June 2, 1944, in United States May 4, 1945, issued December 11, 1945.Google Scholar
Jones, F. D. 1946. Weed-killer 2,4-D. House and Garden 89:147149.Google Scholar
Jones, F. D. 1953. Priority claims on 2,4-D. J. Agric. Food Chem. 1:912.Google Scholar
Kennedy, C. 1993. ICI. The Company That Changed Our Lives. 2nd ed. London: Paul Chapman Publishing. 223 p.Google Scholar
Kephart, L. W. and Griffin, S. W. 1944. Chemical weed control after the war. Pages 7882 in Proceedings of the North Central States Weed Control Conference.Google Scholar
Kirby, C. 1980. The Hormone Weedkillers. A Short History of Their Discovery and Development. Croyden, Great Britain: British Crop Protection Council. 55 p.Google Scholar
Kögl, F., Haagen Smit, A. J., and Erxleben, H. 1934a. Über eine neues Auxin (’Hetero-auxin’) aus Harn. Zeit. Physiol. Chem. 228:90103.Google Scholar
Kögl, F., Haagen Smit, A. J., and Erxleben, H. 1934b. Über den Einfluss der Auxine auf das Wurzelwachstum und die chemische Natur des Auxins der Graskoleoptilen. Zeit. Physiol. Chem. 228:104–12, 121.Google Scholar
Kögl, F. and Kostermans, D.G.F.R. 1934. Hetero-auxin als Stoffwechselprodukt niederer pflanzlicher Organismen. Isolierung aus Hefe. Zeit. Physiol. Chem. 228:113–21.Google Scholar
Kraus, E. J. 1945. Discussion of new chemicals for weed control. Page 72 in Proceedings of the 2nd Annual Meeting of the North Central States Weed Control Conference.Google Scholar
Kraus, E. J. and Mitchell, J. W. 1947. Growth-regulating substances as herbicides. Bot. Gaz. 108:301350.Google Scholar
Lamb, D. and Easton, S. M. 1984. Multiple Discovery. The Pattern of Scientific Progress. London: Avebury Publishing. 248 p.Google Scholar
Lockhart, J.A.R., Samuel, A., and Greaves, M. P. 1990. The evolution of weed control in British agriculture. Pages 4374 In Hance, R. J. and Holly, K., eds. Weed Control Handbook. 8th ed. Oxford: Blackwell Scientific.Google Scholar
Lontz, J. F. 1943. Plant regulant composition and method. U.S. patent 2,322,761. Application February 20, 1942, issued June 29, 1943, application for reissue, June 26, 1948, reissued as 23,115 May 24, 1949.Google Scholar
Markham, E. 1899. The man with the hoe. Pages 1518 In The Man with the Hoe and Other Poems. New York: Doubleday and McClure.Google Scholar
Marth, P. C. and Mitchell, J. W. 1944. 2,4-Dichlorophenoxyacetic acid as a differential herbicide. Bot. Gaz. 106:224232.Google Scholar
Mendelssohn, K. 1977. The Quest for Absolute Zero. The Meaning of Low Temperature Physics. 2nd ed. London: Taylor and Francis. 281 p.Google Scholar
Merck, G. W. 1946a. Peacetime implications of biological warfare. Chem. Eng. News 24:13461349.Google Scholar
Merck, G. W. 1946b. Peacetime implications of biological warfare. Pages 129146 In Science and Life in the World. Volume 2. New York: McGraw-Hill.Google Scholar
Merton, R. 1961. Singletons and multiples in scientific discovery: a chapter in the sociology of science. Proc. Am. Phil. Soc. 105:470486.Google Scholar
Minarik, C. E. 1946. Development of new herbicides by the Chemical Corps. Pages 113119 in Proceedings of the 3rd Annual Meeting of the North Central Weed Control Conference.Google Scholar
Mitchell, J. W., Davis, F. F., and Marth, P. C. 1944. Clover and weed control in turf with plant growth regulators. Golfdom 18 (October): 3436.Google Scholar
Mitchell, J. W. and Hamner, C. L. 1944. Polyethylene glycols as carriers for growth-regulating substances. Bot. Gaz. 105:474483.Google Scholar
Murneek, A. E. 1960. Ezra Jacob Kraus 1885–1960. Plant Physiol. 35:543544.Google Scholar
Murphy, S., Hay, A., and Rose, S. 1984. No Fire, No Thunder. The Threat of Chemical and Biological Weapons. New York: Monthly Review Press. 145 p.Google Scholar
Norman, A. G. 1946. Studies on plant growth regulating substances. Bot. Gaz. 107:475.Google Scholar
Nutman, P. S., Thornton, H. G., and Quastel, J. H. 1945. Plant growth substances as selective weed killers. Inhibition of plant growth by 2,4-D and other plant growth substances. Nature 155:498500.Google Scholar
Peterson, G. E. 1967. The discovery and development of 2,4-D. Agric. Hist. 41:243253;Google Scholar
Pokorny, R. 1941. Some chlorophenoxyacetic acids. J. Am. Chem. Soc. 63:1768.CrossRefGoogle Scholar
Rothamsted Agricultural Experiment Station. 1946. Report for the War Years 1939–1945. Harpendon, Great Britain: Rothamsted Agricultural Experiment Station. 271 p.Google Scholar
Russell, E. J. 1966. A History of Agricultural Science in Great Britain. 1620–1954. London: George Allen and Unwin. 493 p.Google Scholar
Sanders, H. J. and Prescott, R. F. 1959. 2,4-D, weed killer and derivatives. Ind. Eng. Chem. 51:974980.Google Scholar
Sexton, W. A., Slade, R. E., and Templeman, W. G. 1945. Prevention and destruction of weeds. British Patent 573,929, application April 7, 1941, complete specification April 10, 1942, issued December 13, 1945.Google Scholar
Sexton, W. A., Slade, R. E., and Templeman, W. G. 1948. Prevention and destruction of weeds. U.S. patent 2,453,983, in Great Britain April 7, 1941, application August 27, 1945, issued November 16, 1948.Google Scholar
Sherwin-Williams Co. v. American Chemical Paint Co. 1947. Fed. Suppl. 68:594595.Google Scholar
Skoog, F. and Thimann, K. V. 1934. Further experiments on the inhibition of the development of lateral buds by growth hormone. Proc. Natl. Acad. Sci. 20:480485.Google Scholar
Slade, R. E., Templeman, W. G., and Sexton, W. A. 1945. Plant growth substances as selective weed killers. Differential effects of plant-growth substances on plant species. Nature 155:497498.Google Scholar
Snyder, K. M. 1945. Weeds no more. Chem. Dig. 4:188189.Google Scholar
Special Products Division, Chemical Warfare Service. 1946. Plant growth regulators. Science 103:469470.Google Scholar
Szmedra, P. 1997. Banning 2,4-D and the phenoxy herbicides: potential economic impact. Weed Sci. 45:592598.Google Scholar
Templeman, W. G. 1939. The effects of some plant growth substances on dry-matter production in plants. Empire J. Exp. Agric. 7:7688.Google Scholar
Templeman, W. G. 1945. Harnessing the hormones. Ctry. Life 98:923.Google Scholar
Templeman, W. G. 1946. Selective weed control by plant growth promoting substances. J. Min. Agric. 53:105108.Google Scholar
Templeman, W. G. 1955. The uses of plant growth substances. Ann. Appl. Biol. 42:162173.Google Scholar
Templeman, W. G. and Marmory, C. J. 1940. The effect upon the growth of plants of watering with solutions of plant growth substances and of seed dressings containing these materials. Ann. Appl. Biol. 27:453471.Google Scholar
Templeman, W. G. and Sexton, W. A. 1946. The differential effects of synthetic plant growth substances and other compounds upon plant species. I. Seed germination and early growth responses to β-naphthaleneacetic acid and compounds of the general formula aryl-OCH2COOR. Proc. R. Soc. London 133B:300313.Google Scholar
Thimann, K. V. 1935. On an analysis of the activity of two growth-promoting substances on plant tissues. Proc. Kon. Akad. Wet. Amst. 38:896912.Google Scholar
Thimann, K. V. and Koepfli, J. B. 1935. Identity of the growth-promoting and root-forming substances of plants. Nature 135:101102.Google Scholar
Tincker, M.A.H. 1941. Application of growth substances in practice. Nature 147:439442.Google Scholar
Tukey, H. B. 1945. 2,4-D the new weed killer. Rural New Yorker 104 (January 20): 59.Google Scholar
Vöchting, H. 1888. Über die Lichtstellung der Laubblätter. Bot. Zeit. 46:501514, 517–525, 533–541, 549–560.Google Scholar
Willard, C. J. 1951. Where do we go from here? Weeds 1:912.Google Scholar
Wittwer, S. H. 1971. Growth regulators in agriculture. Outlook Agric. 6:205217.Google Scholar
Zimmerman, P. W. and Hitchcock, A. E. 1942. Substituted phenoxy and benzoic acid growth substances and the relation of structure to physiological activity. Contrib. Boyce Thompson Inst. 12:321343.Google Scholar
Zimmerman, P. W., Hitchcock, A. E., and Wilcoxon, F. 1939. Responses of plants to growth substances applied as solutions and as vapors. Contrib. Boyce Thompson Inst. 10:363376.Google Scholar
Zimmerman, P. W. and Wilcoxon, F. 1935. Several chemical growth substances which cause initiation of roots and other responses in plants. Contrib. Boyce Thompson Inst. 7:209229.Google Scholar
Zuckerman, H. 1988. The sociology of science. Pages 511574 In Smelser, N. J., ed. Handbook of Sociology. Newbury Park, CA: Sage Publications.Google Scholar