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Surgical undercutting prevents receptor redistribution in developing kitten visual cortex

Published online by Cambridge University Press:  02 June 2009

C. Shaw ,
G. Prusky  and
M. Cynader
C. Shaw
Affiliation:
Department of Ophthalmology, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia
G. Prusky
Affiliation:
Departments of Psychology, Physiology, and Biophysics, Dalhousie University, Halifax, Nova Scotia
M. Cynader
Affiliation:
Department of Ophthalmology, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia
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Abstract

Recent studies have shown that several receptor populations in cat visual cortex undergo alterations in their laminar distributions during postnatal development (Shaw et al., 1984a, b; 1986b). These redistributions occur during the first few months of postnatal life, coincident with the physiologically defined critical period for cortical plasticity. In the present communication, we demonstrate that receptor redistributions can be prevented from occurring, or progressing once started, by surgically isolating the visual cortex at appropriate postnatal ages. These data suggest that the maturation of the chemical circuitry of the visual cortex is dependent on factors of extrinsic origin.

Keywords

ReceptorAcetylcholineCholecystokininAdenosineGABALaminar distributionCat visual cortexPostnatal developmentCritical period
Type
Research Article
Information
Visual Neuroscience , Volume 1 , Issue 2 , March 1988 , pp. 205 - 210
Copyright
Copyright © Cambridge University Press 1988

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